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How much do single cell core jobs pay per hour?

As of Sep 5, 2026, the average hourly pay for single cell core in the United States is $21.64, according to ZipRecruiter salary data. Most workers in this role earn between $16.83 and $27.16 per hour, depending on experience, location, and employer.

What is a single cell core?

A Single Cell Core is a specialized facility within a research institution that provides expertise, equipment, and services for single-cell genomics and related technologies. These cores support researchers in isolating, processing, and analyzing individual cells to better understand cellular heterogeneity in complex tissues. Services may include single-cell RNA sequencing, library preparation, data analysis, and consultation. Single Cell Cores are essential for advancing research in fields such as cancer biology, immunology, and developmental biology.

What are the key skills and qualifications needed to thrive as a single cell core specialist?

To thrive as a Single Cell Core specialist, you need a strong background in molecular biology, genomics, and experience with single-cell sequencing techniques, often supported by an advanced degree in a life science field. Familiarity with technical tools such as flow cytometry, next-generation sequencing platforms, and data analysis software like Seurat or Cell Ranger is essential. Strong problem-solving abilities, attention to detail, and effective communication are key soft skills for collaborating with researchers and ensuring high-quality results. These competencies are crucial for generating reliable data, facilitating cutting-edge research, and advancing scientific discoveries in the field.

What are some common challenges faced by professionals working in a single cell core facility, and how can new team members prepare for them?

Professionals in a Single Cell Core facility often encounter challenges such as troubleshooting complex instrumentation, managing large volumes of high-dimensional data, and ensuring sample quality throughout the workflow. New team members can prepare by developing strong technical skills in single cell platforms (like 10x Genomics or Fluidigm), familiarizing themselves with bioinformatics tools, and cultivating effective communication with researchers to understand experiment goals. Working collaboratively within a multidisciplinary team and staying current with emerging single cell technologies will also help overcome these challenges and contribute to the core’s success.

What is the difference between Single Cell Core vs Single Cell Technician?

AspectSingle Cell CoreSingle Cell Technician
CredentialsTypically requires a bachelor's degree in biology, biotechnology, or related fieldsUsually requires a similar degree or certification in laboratory techniques
Work EnvironmentResearch laboratories, biotech companies, academic institutionsLaboratories, research facilities, biotech companies
Job FocusProviding core services for single cell analysis, data processing, and sample preparationPerforming technical procedures, sample handling, and data collection

The Single Cell Core generally refers to a facility or service providing specialized single cell analysis support, while a Single Cell Technician is an individual performing technical tasks within that environment. Both roles require similar educational backgrounds and work in comparable settings, but the Core often oversees multiple technicians and manages core services.

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Single Cell Core jobs near you
Infographic showing various Single Cell Core job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 16% Part Time, and 2% Contract. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $45,021 per year, or $21.6 per hour.

Scientist II, Genomic Core

Xaira Therapeutics

South San Francisco, CA • On-site

Full-time

Re-posted 13 days ago

Key responsibilities

  • Perform high-quality next-generation sequencing operations across Illumina platforms, including MiSeq, NextSeq, and NovaSeq.

  • Independently design, develop, optimize, validate, and troubleshoot sequencing workflows to improve data quality, throughput, scalability, and reproducibility.

  • Prepare and QC sequencing libraries for various applications such as 10x Genomics single-cell RNA sequencing, bulk RNA sequencing, CRISPR-based sequencing assays, and targeted sequencing workflows.

Job description

About the Role

As a Scientist II on Xaira's Genomics Core team within the High Throughput Biology organization, you will play a key role in generating high-quality sequencing data that powers our discovery platform and AI-driven research. You will serve as a technical leader responsible for designing, developing, optimizing, and executing next-generation sequencing (NGS) workflows, with a primary focus on Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq. You will partner closely with Functional Genomics, Disease Biology, Automation, and Computational Biology teams to develop scalable sequencing strategies that support CRISPR-based perturbation studies, single-cell genomics, and other high-throughput discovery efforts.

The ideal candidate is an experienced experimental scientist with deep expertise in NGS library preparation, Illumina sequencing operations, and 10x Genomics workflows. This is a highly collaborative, hands-on laboratory role that requires independent scientific thinking, experimental design, and technical leadership to implement new technologies and continuously improve genomics workflows across the organization.

Responsibilities

  • Perform high-quality next-generation sequencing operations across Illumina platforms, including MiSeq, NextSeq, and NovaSeq.
  • Independently design, develop, optimize, validate, and troubleshoot sequencing workflows to improve data quality, throughput, scalability, and reproducibility.
  • Prepare and QC sequencing libraries for a variety of applications, including 10x Genomics single-cell RNA sequencing, bulk RNA sequencing, CRISPR-based sequencing assays, and targeted sequencing workflows.
  • Design sequencing strategies and provide technical guidance to cross-functional project teams to ensure generation of high-quality datasets that address biological and computational objectives.
  • Partner with Functional Genomics scientists to support Perturb-seq, pooled CRISPR screening, guide sequencing, and other genomics-based discovery programs.
  • Collaborate with Automation Engineers to develop, implement, and scale automated library preparation and sequencing workflows.
  • Work closely with Computational Biology teams to ensure sequencing data meets quality standards for downstream analysis and AI/ML applications.
  • Serve as a technical subject matter expert for sequencing technologies by evaluating new methodologies, identifying experimental risks, troubleshooting complex technical challenges, and recommending scientifically sound solutions.
  • Perform routine maintenance, calibration, and troubleshooting of sequencing instrumentation and associated laboratory equipment.
  • Manage sequencing sample intake, experimental tracking, reagent inventory, and laboratory documentation.
  • Maintain accurate experimental records using electronic laboratory notebooks (ELN) and laboratory information management systems (LIMS).
  • Evaluate and implement emerging sequencing technologies, library preparation methods, and genomics workflows to expand core capabilities.
  • Present technical updates, experimental findings, and workflow improvements to cross-functional project teams.
  • Contribute to laboratory operations while ensuring compliance with safety and quality standards.

Qualifications

  • Ph.D. in Functional Genomics, Molecular Biology, Genetics, Genomics, or a related discipline with 2+ years of industry experience, or M.S./B.S. with equivalent industry experience.
  • Extensive hands-on experience operating Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq.
  • Extensive hands-on experience with 10x Genomics workflows: 3', 5', ATAC, Multiome, Flex, etc. 
  • Strong expertise in next-generation sequencing library preparation, including single-cell RNA-seq, bulk RNA-seq, CRISPR-based sequencing assays, and targeted sequencing workflows.
  • Demonstrated experience supporting CRISPR-based genomics workflows, including Perturb-seq, pooled CRISPR screens, guide sequencing, or related functional genomics applications.
  • Demonstrated ability to independently design, optimize, troubleshoot, and execute complex genomics experiments with minimal supervision.
  • Proven experience developing, validating, and implementing new NGS workflows while driving improvements in data quality, throughput, and reproducibility.
  • Strong understanding of sequencing quality control methods, library characterization techniques, and experimental troubleshooting.
  • Experience collaborating with multidisciplinary teams, including molecular biologists, automation engineers, and computational scientists.
  • Ability to independently prioritize multiple projects while providing scientific and technical leadership within cross-functional teams.
  • Excellent written and verbal communication skills, including the ability to present technical findings to diverse scientific audiences.
  • A proactive, collaborative mindset with strong troubleshooting and problem-solving abilities.
  • Enthusiasm for working in a highly interdisciplinary startup environment.

Preferred Qualifications

  • Experience working in a genomics core facility or high-throughput sequencing laboratory.
  • Experience developing or supporting automated library preparation workflows.
  • Experience with additional 10x Genomics applications such as ATAC, Immune Profiling, Multiome, etc.
  • Experience with molecular cloning, cell engineering, lentiviral workflows, or other functional genomics techniques.
  • Basic familiarity with bioinformatics tools, NGS data quality assessment, and sequencing data analysis pipelines.
  • Experience evaluating and implementing emerging sequencing technologies.
  • Experience supporting AI/ML-driven biological research through generation of high-quality genomic datasets.

Compensation

Annual

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity.  The base pay range for this position is expected to be $124,000 to $155,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.

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