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Sequencing Jobs in California (NOW HIRING)

Nooks

Product Manager - AI Sequencing

San Francisco, CA · On-site

$180K - $225K/yr

About Nooks.ai : Nooks is an applied AI lab building the Agent Workspace for GTM. We design AI agents that operate across the full sales action set, from account strategy to prospect research and ...

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Sequencing information

What is sequencing?

Sequencing in a job context typically refers to the process of determining the order in which tasks, operations, or steps are performed, especially in fields like laboratory science, manufacturing, or project management. In genomics, sequencing specifically involves determining the precise order of nucleotides in DNA or RNA. Professionals working in sequencing roles may operate specialized equipment, analyze data, and ensure quality control. Sequencing is crucial for research, diagnostics, and production efficiency, depending on the industry. Mastery of sequencing techniques and attention to detail are important skills for these positions.

What are the key skills and qualifications needed to thrive as a sequencing technician, and why are they important?

To thrive as a Sequencing Technician, you need a solid background in molecular biology, laboratory techniques, and a relevant degree such as biology or biotechnology. Familiarity with DNA sequencing platforms (like Illumina or Oxford Nanopore), laboratory information management systems (LIMS), and certifications in laboratory safety are typically required. Attention to detail, problem-solving skills, and effective teamwork set outstanding technicians apart. These competencies ensure accurate sequencing results, maintain laboratory efficiency, and support critical research or diagnostic projects.

What are some common challenges faced by professionals working in sequencing labs, and how can they be overcome?

Professionals in sequencing labs often encounter challenges such as maintaining sample integrity, managing large datasets, and troubleshooting instrument malfunctions. To address these, it's important to follow strict protocols for sample handling, stay organized with data management tools, and proactively perform routine equipment maintenance. Collaboration with bioinformaticians and other lab members is also key, as it helps in troubleshooting and optimizing workflows. Ongoing training and staying updated with advances in sequencing technology can further help overcome these challenges.

What is the difference between Sequencing vs DNA Analysis?

AspectSequencingDNA Analysis
Required CredentialsLaboratory certifications, molecular biology trainingLaboratory certifications, molecular biology training
Work EnvironmentLaboratories, research facilitiesLaboratories, research facilities
Industry UsageGenomics, medical research, biotechGenomics, forensic science, medical diagnostics
Common Search/ComparisonYesYes

Sequencing involves determining the exact order of nucleotides in DNA, while DNA analysis encompasses various techniques to interpret and compare DNA sequences. Both roles require similar credentials and are used in comparable environments within genomics and biotech industries. Sequencing is a specific process within the broader scope of DNA analysis, making them closely related but distinct in focus.

What are popular job titles related to Sequencing jobs in California?

For Sequencing jobs in California, the most frequently searched job titles are:

What job categories do people searching Sequencing jobs in California look for?

The top searched job categories for Sequencing jobs in California are:

What cities in California are hiring for Sequencing jobs?

Cities in California with the most Sequencing job openings:

Sequencing jobs near you
Infographic showing various Sequencing job openings in California as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution.

Spatial Sequencing Associate

San Diego, CA • On-site

Singular Genomics
Biotechnology Research and Development • 201 - 500 employees
Learn more about Singular Genomicsexternal

Full-time

Posted 7 days ago

Job description

ABOUT SINGULAR GENOMICS
Singular Genomics is inventing at the forefront of genomics, one of the world's fastest-growing industries. The commercially available G4® Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In addition, the company is currently developing the G4X™ Spatial Sequencer, an upgrade to the G4, which will leverage Singular's proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context. Singular Genomics' mission is to empower researchers and clinicians to advance science and medicine.
We foster a culture of creativity and technical excellence, both catalysts for innovation. We celebrate diversity, emphasize collaboration and, as we rapidly mature, we are constantly looking at ways we can do better for our people.
Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub. Our Manufacturing facility is in Sorrento Valley.
Position Summary:
As a Spatial Sequencing Associate 2, you will support a collaborative team of engineers and scientists to run customer tissue samples on the G4X Spatial Sequencer. The ideal candidate will have experience in standard molecular biology techniques for handling nucleic acids (e.g., DNA/RNA purification, PCR amplification, isothermal amplification, and library preparation for next generation sequencing) and be familiar with common enzymes that interact with DNA/RNA. Experience with next generation DNA sequencing (instrumentation and analysis) and handling of tissues on flow cells is a plus.
Expertise in immunoassays (IHC, IF, ISH), familiarity with microscopy-based readouts (particularly fluorescence) and experience with multiplexed assay workflows are essential. You will provide guidance to assay developers to identify appropriate controls, optimize workflows, and implement enhancements that improve assay robustness and reliability.
Responsibilities:
  • Execute experiments to characterize antibody activity using immunofluorescence or IHC across diverse tissue types and conditions.
  • Support antibody validation efforts using molecular biology techniques (e.g. SDS-PAGE), immunoassays, and/or G4X spatial biology assay across various tissue types.
  • Day-to-day operation of the G4X sequencer.
    • Manually prepare customer samples provided for spatial sequencing.
    • Load consumables and program sequencing runs.
    • Perform primary analysis of run data.
    • Perform regular instrument maintenance.
  • Daily run metrics and quality of sequencing performance review.
  • Complete documentation to support data capture, forms, logbooks, and inventory batch records.
  • Contribute to late-stage optimization of spatial biology workflows, ensuring readiness for product launch.
  • Scheduling, usage forecasting and inventory management of consumables.
  • Complete documentation to support logbooks, and inventory batch records.

Qualifications:
  • BS in a Science or Engineering field or 5 years of working experience in equivalent field.
  • Strong molecular biology laboratory skills, demonstrated by work experience.
  • Hands-on experience with multiplexed and immunoassay workflows (required).
  • Strong analytical and documentation skills; experience maintaining accurate, detailed records.
  • Experience with running, maintaining, and troubleshooting lab equipment.
  • Working knowledge of fluorescence microscopy and imaging-based readouts is a strong plus.
  • Familiarity with spatial biology platforms and workflows is a strong plus.
  • Experience interpreting NGS-based transcriptomic and proteomic data is a strong asset.
  • Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace.

The estimated base salary range for this role based in the United States of America is: $74,900 - $88,100. Additionally, this role is eligible for to receive equity as part of the compensation package. Compensation decisions are dependent on several factors including, but not limited to, an individual's qualifications, location where the role is to be performed, internal equity, and alignment with market data. Should the level of the role change during the hiring process, the applicable salary range may be updated accordingly.
Singular Genomics is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Singular Genomics is committed to working with and providing reasonable accommodations to job applicants with physical or mental disabilities. Applicants with a disability who require a reasonable accommodation for any part of the application or hiring process can provide their name and contact information to our Accommodations team at accommodationsrequest@singulargenomics.com. Your request will be responded to as soon as possible.

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