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Senior Toxicologist Jobs (NOW HIRING)

Amgen

OR · On-site

TSRS at Amgen is seeking a Senior Principal Scientist to serve as a Project Toxicologist and Subject Matter Expert, reporting to a Project Team Representative (PTR) Manager. You will be responsible ...

Medline

Principal Toxicologist

Northfield, IL · On-site +1

$152K - $229K/yr

This senior-level position requires deep expertise in toxicology, a strong understanding of international regulations, and excellent leadership skills. This position ensures product safety and leads ...

Medline

Principal Toxicologist

Northfield, IL

$152K - $229K/yr

This senior-level position requires deep expertise in toxicology, a strong understanding of international regulations, and excellent leadership skills. This position ensures product safety and leads ...

Calibr

SENIOR DIRECTOR, TOXICOLOGY

San Diego, CA · On-site

Senior Director, Toxicology POSITION SUMMARY: The Senior Director of Toxicology will be the primary toxicology expert across our pipeline, driving the design, execution, and interpretation of non ...

Calibr

SENIOR DIRECTOR, TOXICOLOGY

San Diego, CA · On-site

Senior Director, Toxicology POSITION SUMMARY: The Senior Director of Toxicology will be the primary toxicology expert across our pipeline, driving the design, execution, and interpretation of non ...

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How much do senior toxicologist jobs pay per year?

As of Jun 12, 2026, the average yearly pay for senior toxicologist in the United States is $80,287.00, according to ZipRecruiter salary data. Most workers in this role earn between $41,500.00 and $103,000.00 per year, depending on experience, location, and employer.

How does a Senior Toxicologist typically interact with cross-functional teams in a research or regulatory setting?

As a Senior Toxicologist, collaboration with cross-functional teams is a key part of the daily workflow. You will often work closely with chemists, pharmacologists, regulatory affairs specialists, and project managers to interpret toxicological data and ensure safety assessments meet both scientific standards and regulatory requirements. Effective communication and the ability to translate complex findings for non-specialist stakeholders are crucial in this role. This collaborative environment not only supports robust scientific outcomes but also offers opportunities to broaden your expertise and leadership skills.

What are Senior Toxicologists?

Senior Toxicologists are highly experienced scientists who study the effects of chemicals, drugs, and other substances on living organisms. They assess risks, design and lead toxicology studies, and interpret data to help ensure safety and regulatory compliance. Senior Toxicologists often guide teams, advise on policy, and collaborate with other scientists, industry professionals, and regulatory agencies. Their expertise is crucial in pharmaceuticals, environmental protection, consumer products, and public health.

What are the key skills and qualifications needed to thrive as a Senior Toxicologist, and why are they important?

To excel as a Senior Toxicologist, you need advanced knowledge in toxicology, chemistry, and risk assessment, typically supported by a relevant advanced degree and several years of experience. Familiarity with analytical instrumentation, regulatory guidelines (such as GLP, REACH, or EPA regulations), and specialized toxicological databases is essential. Strong analytical thinking, attention to detail, and effective communication skills help in interpreting data and presenting findings to diverse audiences. These competencies ensure accurate safety evaluations, regulatory compliance, and the ability to lead complex toxicology projects.
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Senior Toxicologist jobs near you
Infographic showing various Senior Toxicologist job openings in the United States as of June 2026, with employment types broken down into 78% Full Time, 13% Part Time, 7% Contract, and 2% Nights. Highlights an 94% In-person, 4% Hybrid, and 2% Remote job distribution, with an average salary of $80,287 per year, or $38.6 per hour.

Senior Director, Toxicology

Latigo Biotherapeutics

San Francisco, CA • On-site

$280K - $300K/yr

Full-time

Posted 7 days ago

Job description

Job Title: Senior Director, Toxicology
Position Type: Full Time
Company Description:
Latigo Biotherapeutics, Inc. is a private, early-stage biotechnology company focused on discovering and developing the next generation of non-opioid medicines for pain and pain-related syndromes. Our mission is the development of novel therapies that transform the lives of patients. The company is headquartered in Thousand Oaks, CA and has a highly successful management team and an experiencedBoard of Directors. At Latigo, we value science, patient-focus, and innovation.
Position Description:
The Senior Director of Toxicology will provide strategic and scientific leadership for all aspects of nonclinical safety and toxicology across Latigo's discovery and development pipeline. This role is accountable for defining and executing phase-appropriate nonclinical safety strategies to support candidate selection, IND-enabling activities, first-in-human (FIH) studies, and overall clinical development for small molecule programs.
As a recognized subject matter expert, the Senior Director will serve as a core member of cross-functional project teams and a key contributor to regulatory strategy. This individual will oversee internal and external toxicology resources, mentor and develop nonclinical scientists, and ensure high scientific rigor, regulatory compliance, and efficient execution of nonclinical safety programs.
Key Responsibilities
Strategic & Scientific Leadership
  • Lead the overall nonclinical safety and toxicology strategy from early discovery through IND submission, clinical development, and NDA submission.
  • Serve as the toxicology and nonclinical safety SME on cross-functional project teams, providing clear risk-benefit assessments and strategic recommendations.
  • Define target safety profiles and guide compound progression decisions in partnership with Discovery, DMPK, Clinical Pharmacology, and Clinical Development teams.

Study Design & Execution
  • Design, oversee, and interpret IND-enabling toxicology and safety pharmacology studies, ensuring alignment with regulatory expectations and development timelines.
  • Provide scientific oversight of CROs, consultants, and vendors, including study design, protocol review, data quality, and final report approval.
  • Ensure nonclinical safety and toxicology programs are scientifically sound, efficiently executed, and appropriately staged for development phase.

Regulatory & Compliance
  • Partner closely with Regulatory Affairs to author, review, and approve nonclinical sections of INDs, IBs, briefing documents, and regulatory responses.
  • Support regulatory interactions (FDA and ex-US), including pre-IND, end-of-Phase 2, pre-NDA, and other regulatory meetings.
  • Ensure compliance with GLP, ICH, and FDA regulatory guidance applicable to nonclinical safety.

People & Organizational Leadership
  • Build, mentor, and develop a high-performing nonclinical safety team, fostering scientific excellence and collaborative culture.
  • Contribute to the evolution of nonclinical processes, standards, and best practices as the organization scales.
  • Act as a thought partner to senior R&D leadership on portfolio strategy and organizational capability development.

Qualifications & Experience
  • PhD, DVM, or equivalent in Toxicology, Pharmacology, or a related scientific discipline.
  • 15+ years of industry experience in nonclinical safety/toxicology within biotechnology or pharmaceutical settings.
  • Demonstrated leadership of toxicology programs for small molecule therapeutics from IND-enabling studies through marketing applications
  • Strong track record of regulatory authorship and agency interactions supporting early development programs.
  • Proven ability to lead cross-functional teams and influence development strategy at the program and portfolio level.
  • Experience in therapeutic areas related to pain or neuroscience is preferred.

Core Competencies
  • Deep scientific expertise in nonclinical safety and toxicology
  • Strategic thinking with strong execution focus
  • Clear, persuasive scientific communication
  • Collaborative leadership and people development
  • Comfort operating in a fast-paced, early-stage biotech environment

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