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Senior Systems Engineer Jobs in Rochester, MN (NOW HIRING)

Senior AI/ML Architect - AI Program

Rochester, MN · On-site +1

$68.25 - $91.50/hr

Responsibilities Senior AI/ML Architects at Mayo Clinic serve at the leading edge of data, systems ... engineers, and healthcare professionals, to seamlessly integrate AI technologies into our systems.

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Senior Systems Engineer information

See Rochester, MN salary details

$56.9K

$126.8K

$178.9K

How much do senior systems engineer jobs pay per year?

As of Jul 10, 2026, the average yearly pay for senior systems engineer in Rochester, MN is $126,789.00, according to ZipRecruiter salary data. Most workers in this role earn between $106,200.00 and $145,400.00 per year, depending on experience, location, and employer.

What are Senior Systems Engineers?

Senior Systems Engineers are experienced professionals responsible for designing, implementing, and maintaining complex IT systems within an organization. They oversee the integration of hardware and software, ensure system reliability, and troubleshoot advanced technical issues. Senior Systems Engineers often lead projects, mentor junior staff, and collaborate with other departments to meet organizational goals. Their role is critical in maintaining the infrastructure that supports business operations.

What are some common challenges faced by Senior Systems Engineers when integrating new technologies into existing infrastructure?

Senior Systems Engineers often encounter challenges such as ensuring compatibility between legacy systems and new technologies, minimizing downtime during migrations, and addressing unforeseen security vulnerabilities. Effective integration requires thorough planning, cross-team collaboration, and detailed testing to avoid disruptions to business operations. Staying current with emerging technologies and adopting best practices for change management are essential for overcoming these challenges and ensuring smooth implementation.

What are the key skills and qualifications needed to thrive as a Senior Systems Engineer, and why are they important?

To thrive as a Senior Systems Engineer, you need expertise in systems architecture, troubleshooting, and network administration, typically supported by a degree in computer science or a related field and several years of relevant experience. Familiarity with virtualization platforms, cloud services (like AWS or Azure), automation tools (such as Ansible or PowerShell), and certifications like CompTIA, Microsoft, or Cisco are often required. Outstanding problem-solving, communication, and project management skills help you lead initiatives and collaborate effectively across teams. These competencies are crucial for ensuring system reliability, scalability, and security in complex IT environments.

What Is a Senior Systems Engineer?

A senior systems engineer is an IT (information technology) professional tasked with designing and maintaining network systems and security. Examples include large server or storage systems, computer networks, and mainframes. As a systems engineer, your primary duties are to oversee the daily operations of your facility and lead a team of engineers in designing new systems to replace old ones. You may work for a company that provides engineering services and solutions for other businesses, or you may be part of a large university or other institution's IT department. Skills needed for the career include the ability to work independently, leadership, and analytical problem-solving. A bachelor’s degree in electrical engineering or IT and significant experience in a lower systems engineering position are essential qualifications.

What is the difference between Senior Systems Engineer vs Systems Administrator?

AspectSenior Systems EngineerSystems Administrator
CertificationsCompTIA Security+, Cisco CCNA, Microsoft certificationsCompTIA A+, Network+, Microsoft certifications
Work EnvironmentDesigning, implementing, and troubleshooting complex systemsManaging daily system operations and user support
Industry UsageIT, technology, enterprise environmentsIT support, small to medium businesses

While both roles involve working with IT systems, Senior Systems Engineers focus on designing and implementing complex infrastructure, whereas Systems Administrators handle routine maintenance and user support. The senior role typically requires more advanced certifications and experience, and often involves strategic planning and system architecture.

What are the most commonly searched types of Systems Engineer jobs in Rochester, MN? The most popular types of Systems Engineer jobs in Rochester, MN are:
What are popular job titles related to Senior Systems Engineer jobs in Rochester, MN? For Senior Systems Engineer jobs in Rochester, MN, the most frequently searched job titles are:
What cities near Rochester, MN are hiring for Senior Systems Engineer jobs? Cities near Rochester, MN with the most Senior Systems Engineer job openings:
Infographic showing various Senior Systems Engineer job openings in Rochester, MN as of July 2026, with employment types broken down into 92% Full Time, 5% Part Time, and 3% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $126,789 per year, or $61 per hour.
Senior Principal AI/ML Engineer - AI Program

Senior Principal AI/ML Engineer - AI Program

Mayo Clinic

Rochester, MN • On-site

$127K - $175K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 17 days ago


Mayo Clinic rating

7.8

Company rating: 7.8 out of 10

Based on 688 frontline employees who took The Breakroom Quiz

105th of 880 rated healthcare providers


Job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.

Responsibilities

AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems, and computer sciences. They work closely with a multidisciplinary team, including clinicians, user experience designers, product managers, IT professionals, and external partners, to develop and deploy effective, efficient, and ethical AI/ML solutions into clinical practice to enhance patient care and operational efficiency.

As a Senior Principal AI/ML Engineer, you will lead the full spectrum of the AI life cycle from ideation to production. You understand the clinical environment well, including workflows, challenges, and requirements of healthcare providers and patients. You will leverage advanced techniques in AI/ML to analyze vast amounts of healthcare data, including patient records, medical imaging, and genomic information, and other multimodal data sources, to develop AI solutions that meet clinical needs and are integrated smoothly into clinical processes. This includes guiding the design and evaluation of foundation models, vision encoders, multimodal architectures, representation learning approaches, and data fusion strategies that enable robust clinical AI applications. You will develop, integrate, and standardize software components and create, maintain, and follow quality system procedures. You will guide the engineering of systems that are pivotal to developing and deploying these solutions and provide technical leadership on model architecture decisions, including multimodal learning approaches, model adaptation strategies, evaluation methodologies, interpretability techniques, and performance optimization for clinical AI systems. This will encompass everything from design requirements, development, component creation, verification, non-clinical validation, and risk mitigation to ensure our digital health technology products meet and exceed regulatory requirements and setting new benchmarks for safety and effectiveness in clinical settings. Your expertise will also extend to facilitating consistent and automated AI software solution development and releases through the design, testing, and maintenance of tools and associated CI/CD pipelines.

This role is instrumental in leading consultative services to departments and divisions, offering insights into complex business problems. The role requires deep technical judgment in understanding how AI models learn, represent information, and perform across diverse clinical modalities, enabling informed decisions regarding model design, explainability, reliability, and clinical suitability. Your ability to communicate complex findings in easily understandable terms to non-technical users will bridge the gap between sophisticated AI technologies and clinical applications.
Senior Principal AI/ML Engineers are recognized as top technical authorities in the field of AI/ML and play a critical role in driving innovation and shaping the strategic direction of AI/ML initiatives at Mayo Clinic.

Other Responsibilities May Include:
  Providing strategic direction and technical leadership for AI Engineering initiatives.
  Working with leadership team to define the AI roadmap and prioritize projects aligned with organizational objectives.
  Leading component design, development, integration, and standardization to create AI-driven solutions that seamlessly integrate into clinical practice to enhance patient care and clinic operations.
  Leading the collaboration with multidisciplinary teams, including clinicians, user experience designers, product managers, and IT professionals, to understand user needs, workflows, and clinical requirements and assess feasibility. Translating user feedback and requirements into design concepts and usability specifications for AI solutions.
  Leading the interpretation of data analysis to guide strategic choices and clarify complex insights for non-technical users to connect AI technologies and clinical applications. 
  Leading consultative services to clinical work units or AI product teams, offering insights and strategies to address complex business problems.
  Leveraging machine learning techniques such as deep learning, natural language processing, computer vision, multimodal learning, foundation models, and large language models to lead the design, development, and deployment of end-to-end AI solutions for healthcare applications. This includes evaluating and guiding architectural choices involving vision encoders, multimodal fusion approaches, representation learning, and model adaptation strategies.
  Establish rigorous evaluation methodologies and performance metrics to assess the effectiveness, usability, and impact of AI solutions in real-world healthcare settings.
  Ensuring compliance with ethical guidelines, regulatory requirements, and data privacy standards in the development and deployment of AI solutions by the AI development team.
  Overseeing the engineering of systems crucial for developing and deploying AI solutions.
  Facilitating consistent and automated AI software solution development and releases through the design, testing, and maintenance of tools and associated CI/CD pipelines.
  Defining and implementing best practices and standards for AI development and deployment methodologies, tools, and platforms.
  Providing mentorship, guidance, and technical leadership to junior engineers within the AI enablement team. May have supervisory responsibilities.
  Fostering a culture of collaboration, innovation, and knowledge sharing across the organization.
  Supporting talent development initiatives, including training programs, technical workshops, and skill-building activities to enhance team capabilities.
  Contributing to the development of new AI methods and technologies that can advance the state-of-the-art in healthcare AI, including novel approaches in multimodal learning, foundation models, representation learning, computer vision, and clinical AI evaluation. 
  Publishing and presenting the results of AI development and translation in peer-reviewed journals and conferences.
This is a full-time remote position within the United States.
Mayo Clinic will not sponsor or transfer visas for this position including F1 OPT STEM.
 


Qualifications

Required Qualifications:
A master's degree in engineering, computer science, mathematics, health science, or a related field with 9 years of relevant experience, or a bachelor's degree with 11 years of relevant experience. 
  Extensive (9+ years) experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an acute understanding of healthcare technology.
  Demonstrated leadership in managing complex projects, with a proven ability to navigate intricate project requirements and deliver successful outcomes.
  Proven success in fostering collaboration across diverse teams and effectively communicating complex technical concepts to non-technical stakeholders.
  Demonstrated expertise in cloud infrastructure environment and software development tools.
  Experience working with large, complex, and heterogeneous data sets, preferably in healthcare. 
  Strong skills in AI/ML techniques and frameworks.
  Expertise with best practices in data engineering, data science, AI Engineering, and the MLOps communities.
  In-depth knowledge of healthcare domain, including clinical workflows, electronic health records, medical terminologies, regulatory requirements, and industry standards.
  Demonstrated leadership in administration, education, software development, and technical reporting. 
  Experience mentoring and training less-experienced team members, coupled with strong interpersonal, communication, and time management skills.

Preferred Qualifications:
A Ph.D. or other doctorate degree is preferred. 
  Strong expertise in AI/ML techniques and frameworks, such as deep learning, natural language processing, computer vision, multimodal AI, representation learning, and Generative AI, with proficiency in tools like Python, TensorFlow, PyTorch, sci-kit-learn, Keras, etc.
  Experience with healthcare industry informatics standards, best practices, and common data models. Participation in national or international standards organizations or other domain-specific professional organizations, or extensive implementation experience with common data, development, and deployment standards.
  Excellent communication, collaboration, and stakeholder management skills, with the ability to effectively engage with diverse stakeholders and translate complex technical concepts and results to non-technical audiences.
  Demonstrated experience leading technical/quantitative teams in a regulated environment.
  Familiarity with systems or quality engineering best practices, regulatory standards, and compliance frameworks, with the ability to adapt these effectively to different project scenarios.
  Demonstrated experience creating risk management files and verification/validation strategies for digital health technology products within the healthcare industry.
  Demonstrated expertise in user-centered design, human factors engineering, usability testing methodologies, and evaluation across AI product development. Ability to lead expert reviews using established usability practices and methods. Presents findings in easy-to-understand terms for the business or clinical practice.
  Strong problem-solving abilities, critical thinking skills, and a passion for driving innovation and positive change in healthcare through AI technology.


Exemption Status
Exempt
Compensation Detail
$180,024.00 - $261,019.20 / year
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
Schedule Details
Monday - Friday, 8am - 5pm
International Assignment
No
Site Description
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. 

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'.  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter
Ted KeefeQualifications:

Required Qualifications:
A master's degree in engineering, computer science, mathematics, health science, or a related field with 9 years of relevant experience, or a bachelor's degree with 11 years of relevant experience. 
  Extensive (9+ years) experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an acute understanding of healthcare technology.
  Demonstrated leadership in managing complex projects, with a proven ability to navigate intricate project requirements and deliver successful outcomes.
  Proven success in fostering collaboration across diverse teams and effectively communicating complex technical concepts to non-technical stakeholders.
  Demonstrated expertise in cloud infrastructure environment and software development tools.
  Experience working with large, complex, and heterogeneous data sets, preferably in healthcare. 
  Strong skills in AI/ML techniques and frameworks.
  Expertise with best practices in data engineering, data science, AI Engineering, and the MLOps communities.
  In-depth knowledge of healthcare domain, including clinical workflows, electronic health records, medical terminologies, regulatory requirements, and industry standards.
  Demonstrated leadership in administration, education, software development, and technical reporting. 
  Experience mentoring and training less-experienced team members, coupled with strong interpersonal, communication, and time management skills.

Preferred Qualifications:
A Ph.D. or other doctorate degree is preferred. 
  Strong expertise in AI/ML techniques and frameworks, such as deep learning, natural language processing, computer vision, multimodal AI, representation learning, and Generative AI, with proficiency in tools like Python, TensorFlow, PyTorch, sci-kit-learn, Keras, etc.
  Experience with healthcare industry informatics standards, best practices, and common data models. Participation in national or international standards organizations or other domain-specific professional organizations, or extensive implementation experience with common data, development, and deployment standards.
  Excellent communication, collaboration, and stakeholder management skills, with the ability to effectively engage with diverse stakeholders and translate complex technical concepts and results to non-technical audiences.
  Demonstrated experience leading technical/quantitative teams in a re...


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About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919