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Senior Python Startup Jobs in California (NOW HIRING)

Senior AI/ML Engineer

San Francisco, CA · On-site

$123K - $169K/yr

About the role Our client is a well-funded AI startup building production-grade ML infrastructure ... Strong Python and PyTorch (or JAX) fundamentals * Experience with distributed training, GPU ...

Senior AI/ML Engineer

San Francisco, CA · On-site

$123K - $169K/yr

About the role Our client is a well-funded AI startup building production-grade ML infrastructure ... Strong Python and PyTorch (or JAX) fundamentals * Experience with distributed training, GPU ...

Senior Product Engineer

San Francisco, CA · On-site

$175 - $200/hr

  • PTO

One team, one dream About this role We are looking for a Senior Full Stack Engineer who loves ... Startup experience (not required, but we build and move fast!) Our tech stack * Backend * Python ...

Senior Full Stack Software Engineer

Los Angeles, CA · On-site +1

$160K - $210K/yr

  • Medical

  • Dental

  • Vision

  • PTO

About the Role A growing technology startup is hiring a Senior Full Stack Software Engineer to help ... Backend: Node.js (Express or NestJS) and/or Python (Django or FastAPI) * Databases: PostgreSQL ...

Senior Full Stack Software Engineer

San Francisco, CA · On-site +1

$160K - $210K/yr

  • Medical

  • Dental

  • Vision

  • PTO

About the Role A growing technology startup is hiring a Senior Full Stack Software Engineer to help ... Backend: Node.js (Express or NestJS) and/or Python (Django or FastAPI) * Databases: PostgreSQL ...

Senior Software Engineer

San Francisco, CA · On-site

$144K - $190K/yr

Required : • 3-7 years of relevant engineering experience. • Expertise in Python, Django, and ... an early-stage startup is a plus. • Genuine belief that agentic tools are the future of how ...

Senior Infrastructure Engineer

Los Angeles, CA · On-site

$180K - $300K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

Full-time • On-site at either our SF or LA offices Tech Stack Python, C++, PostgreSQL, Linux ... Prior startup experience or end-to-end product ownership Key Responsibilities * Improve the backend ...

Senior Financial Analyst

Los Angeles, CA · Hybrid

$120K - $150K/yr

Familiarity with SQL, Python, LLM APIs, or other automation technologies (preferred). * Experience ... Experience in crypto, fintech, or a high-growth startup environment (preferred). * CFA, MBA, or ...

Senior R&D Engineer

San Francisco, CA · On-site

$123K - $169K/yr

Current Surgical is a startup company developing technology on the frontier of engineering and ... Knowledge of Python or Matlab for processing test results and test and measurement automation

New

Senior Product Engineer

Palo Alto, CA · On-site

$140 - $250/hr

... Python, FastAPI, and a background in B2B SaaS preferred * Top 15 school required if under 2 years of experience Company Context * Transitioning all engineers to full-stack roles * Fast-paced startup ...

Senior Software Engineer

San Francisco, CA · On-site

$144K - $190K/yr

  • Medical

  • Dental

  • Vision

Work across our stack (React, TypeScript, Python, Go, Node) to deliver end-to-end features, from ... startup environments who prefers context over control and operates with a high degree of agency ...

Be Seen First

... startup that's building the infrastructure behind some of the world's most advanced artificial ... Proficiency in Python and/or JavaScript (Node.js/Next.js) . * Experience with cloud platforms such ...

Senior Staff Engineer

El Segundo, CA · On-site

$120 - $160/hr

Languages: Kotlin, Rust, TypeScript, and Python * Deployments: GitHub Actions, Terraform ... Previous experience in a startup or high-growth environment (50-200 employees) * Experience with ...

Showing results 41-60

Senior Python Startup information

What is the difference between Senior Python Startup vs Python Developer?

AspectSenior Python StartupPython Developer
CredentialsBachelor's or higher in CS, experience in startupsBachelor's in CS or related field, some experience
Work EnvironmentFast-paced startup, cross-functional teamsEstablished companies or startups, team-based
Industry UsageTech startups, innovative projectsVaried industries, software development
Search IntentSenior roles, startup environment, advanced skillsEntry to mid-level roles, Python programming

Senior Python Startup roles typically require more experience, leadership skills, and familiarity with startup environments. Python Developers may have similar technical skills but often at an earlier career stage and in more established settings. The main difference lies in experience level and work context, with Senior Python Startup positions emphasizing leadership and startup agility.

What are the most commonly searched types of Python Startup jobs in California? The most popular types of Python Startup jobs in California are:
What cities in California are hiring for Senior Python Startup jobs? Cities in California with the most Senior Python Startup job openings:
Infographic showing various Senior Python Startup job openings in California as of August 2026, with employment types broken down into 2% Internship, 85% Full Time, 5% Part Time, 2% Temporary, and 6% Contract. Highlights an 80% Physical, 6% Hybrid, and 14% Remote job distribution.

Senior AI/ML Engineer

Clera

San Francisco, CA • On-site

$123K - $169K/yr

Full-time

Re-posted 23 days ago


Job description

About the role
Our client is a well-funded AI startup building production-grade ML infrastructure used by enterprise customers. They are looking for a Senior AI/ML Engineer to own model training pipelines, evaluation systems, and inference serving at scale. Full-time, on-site in San Francisco.

What you will do
  • Design and ship end-to-end ML systems: data pipelines, training, evaluation, deployment

  • Own model performance, latency, and cost trade-offs in production

  • Build evaluation harnesses and offline benchmarks for fast iteration

  • Work directly with product to translate ambiguous goals into measurable model improvements

  • Mentor other engineers on ML best practices and code quality

What we are looking for
  • 4+ years of applied ML engineering in production environments

  • Hands-on experience with LLMs, fine-tuning, RAG, or large-scale recommender systems

  • Strong Python and PyTorch (or JAX) fundamentals

  • Experience with distributed training, GPU optimization, or inference serving

  • Pragmatic about trade-offs between research-grade and ship-grade work

This role is presented by a recruiting partner. Company name shared after an initial conversation.