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Senior Python Software Engineer Jobs in Greenville, SC

Truleo

Senior Software Engineer

Greenville, SC · On-site

$115K - $151K/yr

The Role We're hiring a Senior Software Engineer to join our engineering team in Greenville, SC, on ... Experience with Python, machine learning (ML), ML Ops * Experience building AI-powered systems.

Truleo

Senior Software Engineer

Greenville, SC · On-site

$115K - $151K/yr

The Role We're hiring a Senior Software Engineer to join our engineering team in Greenville, SC, on ... Experience with Python, machine learning (ML), ML Ops * Experience building AI-powered systems.

TRULEO

Senior Software Engineer

Greenville, SC · On-site

$115K - $151K/yr

The Role We're hiring a Senior Software Engineer to join our engineering team in Greenville, SC, on ... Experience with Python, machine learning (ML), ML Ops * Experience building AI-powered systems.

AERONIX INC

Embedded Software Engineer

Greenville, SC · On-site

$90K - $125K/yr

Embedded Software Engineer - Job Title: Software Engineer Department: Engineering Reports To ... Working knowledge of higher-level programming languages, including C++ and Python. * Experience in ...

AERONIX INC

Embedded Software Engineer

Greenville, SC · On-site

$90K - $125K/yr

Embedded Software Engineer - Job Title: Software Engineer Department: Engineering Reports To ... Working knowledge of higher-level programming languages, including C++ and Python. * Experience in ...

AERONIX INC

Embedded Software Engineer

Greenville, SC · On-site

$90K - $125K/yr

Embedded Software Engineer - Job Title: Software Engineer Department: Engineering Reports To ... Working knowledge of higher-level programming languages, including C++ and Python. * Experience in ...

AERONIX INC

Embedded Software Engineer

Greenville, SC · On-site

$90K - $125K/yr

Working knowledge of C++ and Python. QUALIFICATIONS * Bachelor's Degree in Computer Engineering, Software Engineering, or related field. * Minimum 5 years of relevant experience. * US Person required ...

AERONIX INC

Embedded Software Engineer

Greenville, SC · On-site

$90K - $125K/yr

Working knowledge of C++ and Python. QUALIFICATIONS * Bachelor's Degree in Computer Engineering, Software Engineering, or related field. * Minimum 5 years of relevant experience. * US Person required ...

Actalent

Embedded Software Engineer

Greenville, SC

$123K - $162K/yr

Embedded Software Engineer The Embedded Software Engineer will perform full lifecycle development ... Proficient programming skills in Python for embedded or supporting tooling. * Strong proficiency ...

Wyetech

Software Engineer (Hybrid) - 26397

Greenville, SC · On-site

$52.46 - $139.92/hr

If you are a self-motivated, creative, and detail-oriented software engineer who is passionate about developing innovative software solutions, we would love to hear from you. #LI-KB2 #Mid-Senior ...

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All JobsPython Software Engineer JobsSenior Python Software Engineer JobsSenior Python Software Engineer Jobs in Greenville, SC

Senior Python Software Engineer information

See Greenville, SC salary details

$51.7K

$133.5K

$183.4K

How much do senior python software engineer jobs pay per year?

As of Jul 10, 2026, the average yearly pay for senior python software engineer in Greenville, SC is $133,498.00, according to ZipRecruiter salary data. Most workers in this role earn between $114,200.00 and $153,700.00 per year, depending on experience, location, and employer.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

What are some common challenges faced by Senior Python Software Engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What are the key skills and qualifications needed to thrive as a Senior Python Software Engineer, and why are they important?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What does a Senior Python Software Engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.
What are popular job titles related to Senior Python Software Engineer jobs in Greenville, SC? For Senior Python Software Engineer jobs in Greenville, SC, the most frequently searched job titles are:
What job categories do people searching Senior Python Software Engineer jobs in Greenville, SC look for? The top searched job categories for Senior Python Software Engineer jobs in Greenville, SC are:
What cities near Greenville, SC are hiring for Senior Python Software Engineer jobs? Cities near Greenville, SC with the most Senior Python Software Engineer job openings:
Senior Python Software Engineer jobs near you

Senior Software Engineer

Truleo

Greenville, SC • On-site

$115K - $151K/yr

Full-time

Posted 18 hours ago

Job description

About TRULEO
TRULEO builds the first case intelligence platform for law enforcement, and more than 1,000 agencies use us today. Most departments already have the information they need to solve a case, but it's spread across RMS, CAD, jail calls, body-worn camera footage, OSINT, and a dozen other systems that don't talk to each other, and Detectives don't have time to dig through all of it.
TRULEO sits on top of the systems an agency already uses and works the case alongside its detectives. It searches across those sources, connects related information, and surfaces leads in minutes instead of weeks. We don't replace their systems, but we make the data an agency already owns easier to actually use, so investigators can spend their time closing cases instead of running queries.
TRULEO has helped agencies turn thousands of files into real leads, break open cold cases, and solve crimes in real time. And we're hiring engineers to help us bring case intelligence to more departments.
The Role
We're hiring a Senior Software Engineer to join our engineering team in Greenville, SC, on-site. This is a full-stack engineering role. You'll work across React, Node/TypeScript, and PostgreSQL data models. Because our product is AI-driven, you'll also build and improve the agentic systems that make TRULEO useful to detectives. It's a high-ownership role on a small, senior team where you'll ship features end to end, from design through production, and your work will directly shape how cases get solved.
What You'll Do
  • Build and ship customer-facing features across the full stack (front end, back end, and data), and own them from design through production.
  • Design and maintain the APIs and data models behind our core case-intelligence workflows.
  • Develop and improve our AI capabilities
  • Build and maintain the connectors that ingest, organize, and cross-reference data from the third-party systems detectives rely on.
  • Run what you build in production, including the harder parts of rollout - migrations, backfills, feature flags, and debugging live systems.
  • Work within our secure, compliant development process (SOC 2, FBI CJIS) and partner with Product to turn customer needs into features people actually use.
Qualifications
  • 7+ years of professional software engineering experience.
  • Strong full-stack background, with production experience in React, TypeScript, Node.js, and PostgreSQL.
  • Experience with Python, machine learning (ML), ML Ops
  • Experience building AI-powered systems.
  • Comfortable with cloud infrastructure and containerized deployments.
  • A practical, self-directed engineer who communicates clearly and does well on a small team where everyone wears several hats.
  • Able to work on-site in Greenville, SC, and to pass the background check required to work with criminal justice (CJIS) data.

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