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Senior Python Software Engineer Jobs in North Carolina

Sarian, Inc.

Sr. Python Web Developer

Charlotte, NC · On-site

$118K - $159K/yr

Role: Sr. Python Web Developer/Only USC & GC Location: Charlotte, NC Onsite position Fulltime position *****NO C2C***** JD Skill: Sr. Python Web Developer * 9 - 14 Years of experience as Sr.Python ...

Sarian, Inc.

Sr. Python Web Developer

Charlotte, NC · On-site

$118K - $159K/yr

Role: Sr. Python Web Developer Location: Charlotte, NC Onsite position Fulltime position JD Skill: Sr. Python Web Developer * 9 - 14 Years of experience as Sr.Python Web Developer * Expert in Python ...

Sarian, Inc.

Sr. Python Web Developer

Charlotte, NC · On-site

$118K - $159K/yr

Role: Sr. Python Web Developer Location: Charlotte, NC Onsite position Fulltime position *****NO C2C***** JD Skill: Sr. Python Web Developer Must Have Technical/Functional Skills: * Expert in Python ...

Laiba Technologies LLC

Python Developer

Charlotte, NC · On-site

$49 - $67.75/hr

Senior Python & MongoDB Engineer We are looking for a Senior Python & MongoDB Engineer with strong hands-on experience building and supporting high-volume, scalable, mission-critical applications ...

Accord Technologies Inc.

Python developer

Charlotte, NC · On-site

$49 - $67.75/hr

Sr Python developer Work Location : Charlotte NC Face to Face interview needed in charlotte NC 12 ... in software development. * Strong proficiency in Python with frameworks like Flask, FastAPI, or ...

Gravity IT Resources

Senior Software Engineer

Concord, NC · On-site

$150 - $200/hr

Senior Software Engineer - Enterprise Data Platforms Location: Charlotte, NC Schedule: Hybrid - 3 ... API Gateway Software Engineering * Python and/or Java * SQL * API development * Microservices

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Senior Python Software Engineer information

What does a senior Python software engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.

What are the key skills and qualifications needed to thrive as a senior Python software engineer?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What are some common challenges faced by senior Python software engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

Which senior Python software engineer job is in demand?

Senior Python software engineering roles are in high demand across industries such as technology, finance, and healthcare, especially for positions involving data analysis, machine learning, and web development. Skills in frameworks like Django or Flask, along with experience in cloud platforms and version control, enhance job prospects in this field.

What are popular job titles related to Senior Python Software Engineer jobs in North Carolina?

For Senior Python Software Engineer jobs in North Carolina, the most frequently searched job titles are:

What job categories do people searching Senior Python Software Engineer jobs in North Carolina look for?

The top searched job categories for Senior Python Software Engineer jobs in North Carolina are:

What cities in North Carolina are hiring for Senior Python Software Engineer jobs?

Cities in North Carolina with the most Senior Python Software Engineer job openings:

Senior Python Software Engineer jobs near you
Infographic showing various Senior Python Software Engineer job openings in North Carolina as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 11% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 88% Physical, 4% Hybrid, and 8% Remote job distribution.

Sr. Python Developer

Indotronix International Corporation

Durham, NC • On-site

$114K - $154K/yr

Full-time, Contractor

Re-posted 11 days ago

Job description

Sr. Python Developer (Remote, Contract-to-Hire)
Durham, NC | 6-Month Contract-to-Hire | No Visa Sponsorship
About the Role
Join a forward-thinking engineering team as a Sr. Python Developer, supporting mission-critical systems that drive lab order intake, processing, and interpretation. In this high-impact, fully remote position, you'll solve complex, ambiguous problems, lead key integration projects, and set the technical standard for a collaborative, globally distributed team. This is a contract-to-hire opportunity for professionals authorized to work in the U.S. without sponsorship.
Responsibilities
- Own and deliver end-to-end projects across product and platform teams
- Design, build, and maintain a central monolithic system using Python and Django
- Develop robust API-driven system integrations with a strong backend focus
- Modernize and stabilize core platform functionality for long-term scalability
- Provide production support and participate in on-call rotations
- Mentor junior engineers and elevate team performance through technical leadership
- Communicate technical solutions clearly to stakeholders across technical levels
Required Skills and Experience
- 7+ years of professional software engineering experience
- Advanced proficiency in Python and Django
- Strong backend/full-stack development experience, including API design
- Solid TypeScript skills (front and backend development)
- Experience working with MySQL databases
- Demonstrated expertise in system architecture and integration
- Authorized to work in the U.S. without current or future sponsorship
Preferred Skills
- Experience in healthcare, clinical laboratory, or genomics technology
- Familiarity with AWS-native environments and cloud platforms
- Exposure to containerization, Kubernetes, or infrastructure-as-code (e.g., Terraform)
- Experience designing and maintaining multi-consumer API platforms
- Knowledge of AI tools (e.g., Claude, Codex)
Benefits
- Competitive contract compensation with potential for full-time hire
- 100% remote work; collaborate with a distributed, innovative engineering team
- Opportunity to work on cutting-edge, impactful systems in the health tech space
- Fast-paced environment with mentorship and career growth opportunities
How to Apply
Ready to elevate your career and technical impact? Apply now with your resume and a summary of relevant experience.
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About Indotronix

Sourced by ZipRecruiter

In 1986, Indotronix established itself in the staffing space. 22 years later, Avani entered the scene, offering consulting and technology development. Finally, in 2016, the two joined forces to begin delivering talent across all areas, from Staffing to Consulting to unique platform development.

Industry

Recruiting and staffing services

Company size

1,001 - 5,000 Employees

Headquarters location

Rochester, NY, US

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