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Senior Oligonucleotide Jobs (NOW HIRING)

Scorpion Therapeutics

NY · On-site

$125 - $150/hr

What You'll Do Senior Associate Scientist focused on oligomer synthesis and characterization ... Execute solid-phase oligomer and oligonucleotide synthesis using automated synthesis platforms ...

Eli Lilly and Company

Advisor - RNA Chemistry

Indianapolis, IN · On-site

$23.25 - $30.50/hr

The Lilly Genetic Medicine group is at the forefront of oligonucleotide medicinal chemistry ... senior leadership teams Basic Qualifications * Ph.D. in organic chemistry, or a related field with ...

LGC Group

Principal Chemist

Petaluma, CA · On-site

Position Summary The Principal Oligonucleotide Chemist is a senior scientific leader responsible for driving oligonucleotide product development, synthesis, process development, and innovation across ...

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Senior Oligonucleotide information

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How much do senior oligonucleotide jobs pay per year?

As of Sep 7, 2026, the average yearly pay for senior oligonucleotide in the United States is $80,287.00, according to ZipRecruiter salary data. Most workers in this role earn between $41,500.00 and $103,000.00 per year, depending on experience, location, and employer.

What is the difference between Senior Oligonucleotide vs Oligonucleotide Scientist?

AspectSenior OligonucleotideOligonucleotide Scientist
Required CredentialsBachelor's or Master's in Chemistry, Molecular Biology, or related fields; experience in oligonucleotide synthesis and analysisSimilar educational background; focus on research and development of oligonucleotide applications
Work EnvironmentManufacturing, quality control, and production settingsResearch labs, R&D departments, and academic institutions
Employer & Industry UsageBiotech, pharmaceutical companies, and contract manufacturing organizationsResearch institutions, biotech firms, and academia

While both roles require expertise in oligonucleotide chemistry and similar educational backgrounds, Senior Oligonucleotide roles often focus on manufacturing, quality control, and process optimization. Oligonucleotide Scientists typically engage in research and development, exploring new applications and improving oligonucleotide technologies.

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Senior Oligonucleotide jobs near you
Infographic showing various Senior Oligonucleotide job openings in the United States as of August 2026, with employment types broken down into 98% Full Time, and 2% Contract. Highlights an 88% Physical, 5% Hybrid, and 7% Remote job distribution, with an average salary of $80,287 per year, or $38.6 per hour.

Senior Associate Scientist - RGM Chemistry

Scorpion Therapeutics

NY • On-site

$125 - $150/hr

Other

Posted 9 days ago

Job description

What You'll Do

Senior Associate Scientist focused on oligomer synthesis and characterization:

  • Execute solid-phase oligomer and oligonucleotide synthesis using automated synthesis platforms (prepare reagents, set up synthesis cycles, incorporate standard and chemically modified amidites, perform on-bead or post-synthetic modifications as needed).
  • Support synthesis of RNA-related constructs of varied lengths, formats, and chemical modifications.
  • Develop, optimize, and troubleshoot synthetic workflows to improve yield, purity, reproducibility, and process efficiency.
  • Purify synthesized oligomers using chromatography (size-exclusion, anion-exchange, reverse-phase, ion-pair reverse-phase).
  • Characterize materials using LC-MS, HPLC/UPLC, UV-Vis, and other orthogonal techniques.
  • Analyze/interpret results, summarize findings, and recommend next steps for iterative chemistry design.
  • Maintain accurate, complete, and timely experimental records.
  • Support routine operation, maintenance, troubleshooting, and inventory management for key instrumentation and supplies.
  • Collaborate with chemists, biologists, analytical scientists, and project teams.
Let's Find Out If We're a Fit
  • B.S. in chemistry, biochemistry, chemical biology, biology, or related field required; M.S. preferred.
  • Minimum 5 years (B.S.) / 3 years (M.S.) in relevant research, internship, or industry experience required.
  • Preferred: hands-on solid-phase organic synthesis experience (oligonucleotide/peptide/oligomer/polymer/biopolymer workflows).
  • Nice to have: automated synthesis platforms (MerMade, OligoSynt, or comparable); experience with SEC, AEX, RP-HPLC/RPIP-HPLC, and LC-MS.
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