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Senior Information Security Engineer Jobs in Minnesota

Mayo Clinic

SR Information Security Engineer

Rochester, MN

$108K - $146K/yr

The Senior Information Security Engineer is a senior-level technical position responsible for leading complex security engineering initiatives and providing advanced expertise across multiple ...

Mayo Clinic

SR Information Security Engineer

Rochester, MN

$104K - $141K/yr

The Senior Information Security Engineer is a senior-level technical position responsible for leading complex security engineering initiatives and providing advanced expertise across multiple ...

Mayo Clinic

SR Information Security Engineer

Rochester, MN · On-site

$111K - $153K/yr

The Senior Information Security Engineer is a senior-level technical position responsible for leading complex security engineering initiatives and providing advanced expertise across multiple ...

Mayo Clinic

SR Information Security Engineer

Rochester, MN · Hybrid

$134K - $194K/yr

Responsibilities The Senior Information Security Engineer is a senior-level technical position responsible for leading complex security engineering initiatives and providing advanced expertise across ...

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Senior Information Security Engineer information

See Minnesota salary details

$22K

$124.2K

$183.6K

How much do senior information security engineer jobs pay per year?

As of Aug 31, 2026, the average yearly pay for senior information security engineer in Minnesota is $124,201.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,300.00 and $141,500.00 per year, depending on experience, location, and employer.

What does a senior information security engineer do?

A Senior Information Security Engineer is responsible for designing, implementing, and maintaining an organization's security infrastructure. They assess risks, develop security policies, and ensure compliance with regulations. Additionally, they monitor networks for vulnerabilities, respond to security incidents, and provide guidance to junior staff. Their expertise helps protect sensitive data and maintain the integrity of IT systems.

What are the key skills and qualifications needed to thrive as a senior information security engineer?

To thrive as a Senior Information Security Engineer, you need deep expertise in cybersecurity principles, risk assessment, and network security, often supported by a relevant degree and certifications like CISSP or CISM. Familiarity with security information and event management (SIEM) systems, firewalls, vulnerability scanning tools, and scripting languages is typically required. Strong analytical thinking, problem-solving, and effective communication skills help you proactively identify threats and collaborate with IT teams. These skills and qualities are critical to protect organizational assets, ensure regulatory compliance, and respond effectively to evolving cyber threats.

How does a senior information security engineer typically collaborate with other departments to enhance organizational security?

Senior Information Security Engineers often work closely with teams across IT, development, and business units to identify potential security risks and implement effective controls. They participate in cross-functional meetings, review architectural changes, and provide guidance on secure coding practices. This collaboration ensures that security is embedded early in project lifecycles and that all staff are aware of best practices. Building strong relationships with other departments is essential for developing comprehensive security policies and responding effectively to incidents.

What is the difference between Senior Information Security Engineer vs Security Analyst?

AspectSenior Information Security EngineerSecurity Analyst
CertificationsCISSP, CISA, CEHCISSP, Security+
Work EnvironmentDesigning security systems, implementing security measures, managing security projectsMonitoring security alerts, analyzing threats, conducting security assessments
Employer & Industry UsageTech companies, finance, healthcare, governmentIT departments, cybersecurity firms, corporate security teams

The main difference is that Senior Information Security Engineers focus on designing and implementing security solutions, while Security Analysts primarily monitor and analyze security threats. Both roles require relevant certifications and are vital in maintaining organizational security, but they differ in responsibilities and daily tasks.

What are popular job titles related to Senior Information Security Engineer jobs in Minnesota?

For Senior Information Security Engineer jobs in Minnesota, the most frequently searched job titles are:

What job categories do people searching Senior Information Security Engineer jobs in Minnesota look for?

The top searched job categories for Senior Information Security Engineer jobs in Minnesota are:

What cities in Minnesota are hiring for Senior Information Security Engineer jobs?

Cities in Minnesota with the most Senior Information Security Engineer job openings:

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For Senior Information Security Engineer jobs in MN, the most frequently searched job titles are:

Senior Information Security Engineer jobs near you
Infographic showing various Senior Information Security Engineer job openings in Minnesota as of August 2026, with employment types broken down into 1% As Needed, 74% Full Time, 23% Part Time, and 2% Contract. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $124,201 per year, or $59.7 per hour.

SR Information Security Engineer

Rochester, MN

Mayo Clinic
Hospitals • 10K+ employees

7.8

Company rating: 7.8 out of 10

Based on 705 frontline employees who took The Breakroom Quiz

133rd of 896 rated healthcare providers

People enjoy working here

Good employer

Recommended by students

Learn more about Mayo Clinicexternal

$108K - $146K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 5 days ago

Job description

The Senior Information Security Engineer is a senior-level technical position responsible for leading complex security engineering initiatives and providing advanced expertise across multiple information security domains. The position operates with significant autonomy, serves as a technical authority, and is accountable for designing, implementing, and optimizing security solutions that address enterprise risk, regulatory requirements, and business objectives.

This vacancy is not eligible for sponsorship/ we will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. 

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law".  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Bachelor's degree in applicable field plus five (5) years of relevant experience.  Pertinent fields of study and experience include, but are not limited to, information security, computer science, information systems, engineering, or a related field.

Master's degree in applicable field plus four (4) years of relevant experience preferred.  Pertinent fields of study and experience include, but are not limited to, information security, computer science, information systems, engineering, or a related field.

One or more of the following certifications (or equivalent) are required at time of hire: CISSP, CISM, GSEC, OSCP.

Experience securing web applications, APIs, and internet-facing technologies.

Experience with Akamai solutions such as WAAP, Property Manager, Edge DNS, CDN, or similar web security platforms.

Strong understanding of web application security, API security, DNS, TLS/SSL, and threat mitigation techniques.

Experience with scripting, automation, or Infrastructure-as-Code technologies.

Strong analytical, communication, and problem-solving skills.

One or more of the following certifications (or equivalent) are required at the time of hire: CISSP, CISM, GSEC, OSCP.

Preferred Qualifications

Experience with Akamai Bot Manager, API Security, Account Protector, or SiteShield.

Experience with Azure, AWS, or Google Cloud security services.

Knowledge of OWASP Top 10, DDoS protection, and modern application security practices. 

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About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919

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