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Senior IT Systems Administrator

Philadelphia, PA

Hybrid

Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on developing and launching the first curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit and connect with us on LinkedIn.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew.

We’re proud to be a Great Place to Work-Certified™ company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to Work®

Senior IT Systems Administrator

Hybrid - Philadelphia, PA

About the Position

Reporting to the Director of IT and Data Sciences, we are seeking a Senior IT Systems Administrator to support the implementation, operation, and continuous improvement of Cabaletta’s IT infrastructure and collaboration systems. This individual will work across departments to ensure systems are reliable, secure, and aligned with business needs.

This is a hands-on role requiring strong experience with Microsoft 365, AWS hybrid cloud environments, and Linux/Windows systems. The role also involves close collaboration with internal stakeholders and external service providers to support consistent, high-quality IT service delivery.

This role is located in Center City, Philadelphia. We operate in a hybrid work environment, with an expectation of 2+ days per week in the office as needed.

Responsibilities:

• Own and contribute to the design, implementation, configuration, and support of servers, network devices, and firewalls in collaboration with IT and business teams
• Own the operational health of IT systems, including end-user support, break-fix activities, monitoring, patch management, system backup/recovery, system administration, troubleshooting, and issue resolution
• Lead and coordinate Tier 2/3 escalations, working with internal stakeholders and external partners to ensure timely resolution
• Act as a primary technical point of contact for external service providers, helping to ensure alignment with Cabaletta’s operational and security expectations
• Partner with external support providers to support consistent service delivery, including responsiveness, quality of work, and adherence to defined service expectations
• Participate in the review of escalations, recurring issues, and incident trends to identify opportunities for improvement and reduce operational risk
• Support coordination and communication of infrastructure and system changes to ensure appropriate documentation, awareness, and alignment with internal processes
• Collaborate with internal stakeholders and service providers to prioritize work and support a high-quality end-user experience
• Contribute to continuous improvement of IT service delivery processes and operational practices
• Administer and support core Linux and Microsoft technologies across cloud and hybrid environments
• Maintain and support AWS hybrid cloud environments, including EC2, VPC, Elastic Load Balancing (ALB/NLB), RDS, and S3
• Maintain and support Microsoft 365 systems, including Exchange, SharePoint, Teams, and Entra ID
• Support the implementation and maintenance of cybersecurity controls across infrastructure and cloud environments, including identity, access, and endpoint protections
• Support identity and access management practices, including role-based access and least privilege principles
• Assist in monitoring, responding to, and remediating security events in coordination with internal teams and external partners
• Contribute to vulnerability management activities, including patching, system hardening, and periodic security reviews
• Maintain business continuity and disaster recovery systems, including periodic testing to meet data retention and compliance requirements
• Ensure IT systems maintain compliance with cybersecurity and regulatory standards, including participation in audits, risk assessments, and remediation activities
• Create and maintain comprehensive documentation of IT systems (e.g., SOPs, user guides, training materials, test plans, validation documents)
• Support lifecycle management of IT systems across on-premise and cloud platforms
• Collaborate with QA/CSV teams to support validation processes, including development and execution of test scripts
• Support data integrity processes for IT systems and laboratory environments
• Support staff and partners in effectively using technology; provide training as required
• Other assignments and projects as required

Qualifications:

• Bachelor’s degree with 5+ years of experience as a Systems Administrator or similar role in biotech, pharmaceutical, or life sciences industries
• Experience with LAN/WAN networks, including wireless and firewall management
• Experience supporting segmented or regulated network environments is a plus
• Strong experience with AWS services, including EC2, VPC, Elastic Load Balancing (ALB/NLB), RDS, and S3
• Strong experience with Windows Server (2016/2019/2022) and RHEL (7/8/9)
• Experience supporting Microsoft 365 applications, including Exchange, SharePoint, Teams, and Entra ID (SSO, SAML, OIDC)
• Solid understanding of Active Directory, Group Policy, and file system permissions
• Experience with backup and recovery platforms
• Experience supporting cybersecurity practices in a regulated environment, including patch management, access controls, and endpoint security
• Familiarity with firewalls, network security concepts, and identity management
• Exposure to security monitoring tools (e.g., SIEM, endpoint detection and response) is a plus
• Experience working with external service providers or managed services environments is preferred
• Excellent problem-solving, communication, and organizational skills
• Strong curiosity and ability to learn quickly in a fast-paced environment
• Strong client support orientation and ability to work with users across varying technical skill levels
• Comfortable operating in a growing, dynamic organization

Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit 

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.

#LI-HYBRID