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Senior Backend Developer Python Jobs in California

Hubs.is

Senior Backend Engineer

San Francisco, CA · On-site +1

Collaborate with frontend, product and devops teams to ensure seamless integration. * Architect for ... TypeScript, Node.js, Python. * Databases : PostgreSQL and MongoDB at scale. * Performance ...

Nash, Inc.

Senior Backend Engineer

San Francisco, CA · On-site

Senior Backend Engineer San Francisco / Hybrid / Remote About Nash Logistics is the substrate ... Strong proficiency in Python and modern backend frameworks. Experience with Go or TypeScript is a ...

Finvest

Senior Backend Engineer

San Francisco, CA · On-site

We are looking for a senior engineer to join our team in San Francisco. As one of the founding ... Fluent in Node/Typescript, Python, Postgres, and AWS * Proven ability to architect complex ...

FlexAI

Senior Backend Engineer

Santa Clara, CA · On-site

As a Senior Backend Engineer , you'll drive backend architecture, scale platform services, and ... Work with DevOps/SRE on CI/CD, deployment automation, and scalability * Contribute to architecture ...

NimbleRx

Senior Backend Engineer

Redwood City, CA · On-site

NimbleRx is a healthtech company on a mission to simplify access, understanding and management of healthcare. As a Senior Backend Engineer, you will architect technology and customer experiences ...

Nash

Senior Backend Engineer

San Francisco, CA · On-site

About The Role As a Senior Backend Engineer , you will play a critical role in designing and ... Strong Proficiency in Python and backend frameworks. * Experience designing and working with ...

Troveo AI Inc

Senior Back End Engineer

San Francisco, CA · On-site +1

$175K - $195K/yr

Collaborate with platform teams to evolve internal tooling and developer experience Job ... Go, Python, or Java. * Experience with Docker and container orchestration * Experience with cloud ...

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Senior Backend Developer Python information

What does a senior backend developer Python do?

A Senior Backend Developer Python designs, builds, and maintains the server-side logic and databases for web applications, primarily using the Python programming language. They are responsible for ensuring high performance, responsiveness, and security of applications, integrating with front-end elements, and working closely with other developers and stakeholders. Additionally, they often mentor junior developers, review code, and contribute to architectural decisions to ensure scalable and robust backend systems.

What are the key skills and qualifications needed to thrive as a senior backend developer Python?

To thrive as a Senior Backend Developer Python, you need deep expertise in Python programming, software architecture, and experience with databases and API development, usually supported by a computer science degree and several years of professional coding experience. Familiarity with frameworks like Django or Flask, cloud platforms (e.g., AWS, Azure), and version control systems such as Git is typically expected, along with knowledge of containerization tools like Docker. Strong problem-solving skills, collaboration, and clear communication set top performers apart in this role. These skills ensure the development of robust, scalable backend systems that meet business needs and support seamless integration with other technologies.

What are some common challenges faced by senior backend developers working with Python, and how can they be addressed?

Senior Backend Developers working with Python often encounter challenges such as ensuring high performance and scalability of applications, especially when dealing with large volumes of data or high user traffic. Managing dependencies and maintaining clean, modular codebases can also be demanding in complex projects. These challenges are typically addressed by leveraging advanced Python frameworks, implementing robust testing practices, and collaborating closely with DevOps and frontend teams to optimize system architecture and deployment pipelines. Continuous learning and staying updated with best practices in Python and backend development are also key to overcoming these obstacles.

What is the difference between Senior Backend Developer Python vs Backend Developer Python?

AspectSenior Backend Developer PythonBackend Developer Python
Required Experience5+ years, leadership skills1-3 years, foundational skills
CertificationsRelevant certifications (e.g., AWS, Python)Optional, entry-level certifications
Work EnvironmentDesigning architecture, mentoringImplementing features, coding
ResponsibilitiesSystem design, team coordinationCode development, bug fixing

The main difference between a Senior Backend Developer Python and a Backend Developer Python lies in experience, responsibilities, and leadership. Senior developers typically lead projects and mentor others, while backend developers focus on coding and feature implementation. Both roles require strong Python skills and relevant certifications, but senior roles demand more experience and strategic involvement.

What are the most commonly searched types of Backend Developer Python jobs in California?

The most popular types of Backend Developer Python jobs in California are:

What are popular job titles related to Senior Backend Developer Python jobs in California?

For Senior Backend Developer Python jobs in California, the most frequently searched job titles are:

What job categories do people searching Senior Backend Developer Python jobs in California look for?

The top searched job categories for Senior Backend Developer Python jobs in California are:

What cities in California are hiring for Senior Backend Developer Python jobs?

Cities in California with the most Senior Backend Developer Python job openings:

Senior Backend Developer Python jobs near you
Infographic showing various Senior Backend Developer Python job openings in California as of September 2026, with employment types broken down into 2% Internship, 71% Full Time, 23% Part Time, and 4% Contract. Highlights an 76% Physical, 5% Hybrid, and 19% Remote job distribution.

Semiotic Labs - Senior Backend Engineer

San Francisco, CA • On-site, Remote

De Circle
See more jobs at De Circleexternal

Full-time

Re-posted 16 days ago

Job description

Semiotic Labs is a venture studio building ambitious products at the intersection of AI, security, data, and infrastructure. Past ventures include Odos, a leading liquidity aggregator, and Cambrian, which provides low-latency, high-quality DeFi data for financial agents.
We were also core developers of The Graph protocol and have worked on problems including trust-minimized micropayments, low-latency request processing, data verification, and dynamic pricing. Our team has published research at venues such as NeurIPS and built novel optimization systems and production-grade distributed software.
Our latest ventures include:
  • Agentium Studio: a multi-tenant Saas platform for AI-powered financial workflows that operates on confidential documents under SOC 2 controls, accelerating multi-party collaboration for workflows like M&A, diligence, and consulting engagements.
  • AgentVisor: a sandboxing layer for agents with security and observability built in.
  • Agentium OS: an enterprise platform for agent safety, control, and observability.

About the role
We're hiring a Senior Backend Engineer to help build Agentium Studio. You'll design and ship the backend systems behind core product workflows, APIs, integrations, and parts of the agent runtime layer. This is a high-ownership role for someone who enjoys moving between product engineering and systems design. You should be comfortable turning ambiguous requirements into clear technical plans, shipping production code, and raising the bar for reliability, simplicity, and maintainability.
You'll work closely with engineers, researchers, and product stakeholders on problems at the frontier of AI applications, security, and enterprise software.
Tech stack
  • Python 3.12+, FastAPI, Pydantic 2, async SQLAlchemy 2.0
  • PostgreSQL 16 with pgvector and row-level security for tenant isolation
  • Redis, OpenTelemetry, AWS
  • React 19 + Vite frontend; backend engineers should be comfortable reading frontend code during integration work

What you'll do
  • Design, build, and maintain scalable async backend services and APIs in Python.
  • Own core systems end-to-end: architecture, implementation, testing, deployment, and operational excellence.
  • Build systems for multi-tenant workflows, fine-grained permissions, integrations, and agent-driven product experiences.
  • Write and review database migrations and row-level security policies in a compliance-sensitive environment.
  • Improve reliability, observability, and performance across critical paths.
  • Collaborate closely with product, design, and research to translate user needs into robust backend architecture.
  • Contribute to engineering standards, code review culture, and team ways of working.
  • Help shape technical direction in a fast-moving environment with evolving product requirements.

Why join
  • Work on technically challenging products at the intersection of AI, security, and enterprise software.
  • Join a small, senior team with deep experience in research, distributed systems, and production engineering.
  • Have meaningful influence over architecture, product direction, and engineering culture.
  • Build products with real-world impact, not just prototypes

  • 5+ years of professional software engineering experience with substantial backend development experience.
  • Strong production experience building backend services in Python.
  • Strong experience with asynchronous programming in Python, such as asyncio, async database access, or high-concurrency service development.
  • Deep PostgreSQL experience, including schema design, query tuning, transactions, and production migrations.
  • Experience designing or implementing multi-tenant data isolation and access control.
  • Strong software design fundamentals: modular architecture, testing discipline, maintainability, and clear interface design.
  • Experience with Redis or similar infrastructure for caching, queues, rate limiting, or pub/sub.
  • Ability to independently own projects and make sound technical tradeoffs in ambiguous environments.
  • Strong communication skills and a collaborative, low-ego working style.

Strongly preferred
  • Experience with FastAPI, Starlette, Litestar, or another modern Python web framework.
  • Experience building backend systems for AI products, agentic workflows, or LLM-powered applications, such as RAG pipelines, tool-calling agents, or orchestration layers.
  • Experience with security-sensitive or enterprise systems, including access controls, audit logging, and compliance-driven engineering constraints.
  • Experience with OpenTelemetry or comparable production observability tooling.

Nice to have
  • Experience with pgvector, SurrealDB, or other vector retrieval systems.
  • Exposure to SOC 2, fintech, healthtech, or other regulated environments.
  • Experience with agent runtimes, sandboxing, or MCP integrations.
  • Familiarity with distributed systems, asynchronous processing, and performance optimization.
  • Startup or zero-to-one experience.
  • Comfort reading TypeScript or React during frontend-backend integration work.

Who you are
  • You have strong engineering judgment and care about systems that are simple, reliable, and useful.
  • You thrive in small, high-trust teams where autonomy comes with real ownership.
  • You enjoy hard problems but stay grounded in user value and practical execution.
  • You bring a growth mindset, high standards, and a willingness to learn across disciplines.

Apply