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Senior Backend Developer Python Jobs in San Francisco, CA

Dodo

Senior Backend Developer (NodeJS)

San Francisco, CA · On-site

$142K - $184K/yr

They are seeking a Senior Backend Developer to architect and build scalable backend services, design APIs, and develop real-time voice AI systems for healthcare applications. Responsibilities : • ...

Addison Group

Sr. Backend Engineer

San Ramon, CA · On-site

$65 - $75/hr

Title : Sr. Backend Engineer Location : San Ramon, CA Pay : $65-75/hr Job Type : 6 Month Contract ... React, TypeScript · Backend: o Python (API platform, AWS Lambda, dynamic DBs) o Node.js, ...

Addison Group

Sr. Backend Engineer

San Ramon, CA · On-site

$65 - $75/hr

Title : Sr. Backend Engineer Location : San Ramon, CA Pay : $65-75/hr Job Type : 6 Month Contract ... React, TypeScript · Backend: o Python (API platform, AWS Lambda, dynamic DBs) o Node.js, ...

Addison Group

Sr. Backend Engineer

San Ramon, CA · On-site

$65 - $75/hr

Title : Sr. Backend Engineer Location : San Ramon, CA Pay : $65-75/hr Job Type : 6 Month Contract ... React, TypeScript • Backend: o Python (API platform, AWS Lambda, dynamic DBs) o Node.js, ...

Nametag

Senior Backend Engineer

San Francisco, CA · On-site

$120K - $190K/yr

Build internal tools and dashboards that improve operational visibility and developer workflows ... Strong experience with backend languages such as Node.js, Go, Python, Java, or similar.

Hedra

Senior Backend Engineer

San Francisco, CA · On-site

$175K - $275K/yr

... developer platform and inference infrastructure. You'll build the services and APIs that allow ... You'll work across the core platform, building secure, reliable, and scalable Python services on ...

NxT Level

Senior Backend Engineer (SF)

San Francisco, CA · On-site

Build and scale backend services in Python and FastAPI supporting millions of healthcare requests ... Developer infrastructure or API platforms Experience with FHIR, HL7, EHR integrations, QHINs, HIPAA ...

NxT Level

Senior Backend Engineer (SF)

San Francisco, CA · On-site

Build and scale backend services in Python and FastAPI supporting millions of healthcare requests ... Developer infrastructure or API platforms Experience with FHIR, HL7, EHR integrations, QHINs, HIPAA ...

NxT Level

Senior Backend Engineer (SF)

San Francisco, CA · On-site

$200K - $240K/yr

Build and scale backend services in Python and FastAPI supporting millions of healthcare requests ... Developer infrastructure or API platforms Experience with FHIR, HL7, EHR integrations, QHINs, HIPAA ...

P2P

Senior Backend Engineer

San Mateo, CA · On-site

Role Dinari is looking for senior backend engineers, eager to tackle the challenges of integrating ... Proficiency in Python or Java * Familiarity with blockchain and smart contracts * Experience ...

Darren Caddle

Back End Developer

San Francisco, CA

$180K - $220K/yr

DarrenCaddle is looking for Senior backend software developers to help support and grow our client ... Strong preference will be given to candidates who have experience: - Writing code in Python, Elixir ...

Phonely Ltd

Senior Backend Engineer

San Francisco, CA · On-site

$200K - $350K/yr

Senior Backend Engineer (Python) At some point in the future, every business will answer their phone with voice AI. We are making sure that when they build that AI agent, the experience of doing so ...

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How much do senior backend developer python jobs pay per year?

As of Sep 11, 2026, the average yearly pay for senior backend developer python in San Francisco, CA is $174,644.00, according to ZipRecruiter salary data. Most workers in this role earn between $171,400.00 and $197,300.00 per year, depending on experience, location, and employer.

What does a senior backend developer Python do?

A Senior Backend Developer Python designs, builds, and maintains the server-side logic and databases for web applications, primarily using the Python programming language. They are responsible for ensuring high performance, responsiveness, and security of applications, integrating with front-end elements, and working closely with other developers and stakeholders. Additionally, they often mentor junior developers, review code, and contribute to architectural decisions to ensure scalable and robust backend systems.

What are the key skills and qualifications needed to thrive as a senior backend developer Python?

To thrive as a Senior Backend Developer Python, you need deep expertise in Python programming, software architecture, and experience with databases and API development, usually supported by a computer science degree and several years of professional coding experience. Familiarity with frameworks like Django or Flask, cloud platforms (e.g., AWS, Azure), and version control systems such as Git is typically expected, along with knowledge of containerization tools like Docker. Strong problem-solving skills, collaboration, and clear communication set top performers apart in this role. These skills ensure the development of robust, scalable backend systems that meet business needs and support seamless integration with other technologies.

What are some common challenges faced by senior backend developers working with Python, and how can they be addressed?

Senior Backend Developers working with Python often encounter challenges such as ensuring high performance and scalability of applications, especially when dealing with large volumes of data or high user traffic. Managing dependencies and maintaining clean, modular codebases can also be demanding in complex projects. These challenges are typically addressed by leveraging advanced Python frameworks, implementing robust testing practices, and collaborating closely with DevOps and frontend teams to optimize system architecture and deployment pipelines. Continuous learning and staying updated with best practices in Python and backend development are also key to overcoming these obstacles.

What is the difference between Senior Backend Developer Python vs Backend Developer Python?

AspectSenior Backend Developer PythonBackend Developer Python
Required Experience5+ years, leadership skills1-3 years, foundational skills
CertificationsRelevant certifications (e.g., AWS, Python)Optional, entry-level certifications
Work EnvironmentDesigning architecture, mentoringImplementing features, coding
ResponsibilitiesSystem design, team coordinationCode development, bug fixing

The main difference between a Senior Backend Developer Python and a Backend Developer Python lies in experience, responsibilities, and leadership. Senior developers typically lead projects and mentor others, while backend developers focus on coding and feature implementation. Both roles require strong Python skills and relevant certifications, but senior roles demand more experience and strategic involvement.

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Senior Backend Developer Python jobs near you

Senior Backend Engineer (Python)

San Francisco, CA • On-site

Phonely
See more jobs at Phonelyexternal

Full-time

Re-posted yesterday

Job description

Job Summary:
Phonely is a fast-growing company focused on revolutionizing voice AI for businesses. They are seeking a Senior Backend Engineer to build and maintain Python-based systems that drive voice AI interactions, ensuring high performance and reliability.
Responsibilities:
• Build and maintain Python-based state systems that drive what the voice AI says and does across complex, real-time conversations.
• Integrate and orchestrate multiple LLM providers, including prompt design, tool/function calling, routing, and fallbacks.
• Write clean, maintainable, high-performance Python code, leveraging asyncio, OOP, and best practices.
• Write automated tests and validation suites to ensure correctness, resilience, and safe iteration of agent logic and state transitions.
• Monitor production systems, debug agent behavior, and continuously improve reliability and conversation quality.
• Implement comprehensive metrics, logging, and alerting to validate correctness, detect failures early, and maintain extremely high availability.
• Design database schemas, optimize queries, and operate both SQL and NoSQL databases in production.
• Build and operate authentication and authorization mechanisms with strong security guarantees.
• Design and build microservices-based architectures.
Qualifications:
Required:
• 5+ years writing python, experience writing async web apps using fast api, testing frameworks
• Understanding of LLMs, APIs, Cloud, CI/CD pipelines
• Comfortable with understanding technical specifications
• Understanding of good architecture, security practices
• Strong technical and communication skills
• Experience with AWS & Kubernetes
Company:
Phonely provides an AI-powered voice platform that automates phone interactions for businesses through virtual agents. Founded in 2023, the company is headquartered in San Francisco, USA, with a team of 11-50 employees. The company is currently Early Stage.

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