Overcoming tumor immune evasion, antigen loss, exhaustion, and senescence * Mechanisms of on-target/off-tumor toxicity and immune-related adverse events * Translational studies bridging preclinical ...
Overcoming tumor immune evasion, antigen loss, exhaustion, and senescence * Mechanisms of on-target/off-tumor toxicity and immune-related adverse events * Translational studies bridging preclinical ...
Research Technologist - Gingery Lab - Limited Tenure
$27.99 - $41.98/hr
The Gingery laboratory investigates local and systemic impacts of aging, cellular senescence, immune dysregulation, and metabolic dysfunction in musculoskeletal diseases and conditions. These include ...
Research Technologist - Gingery Lab - Limited Tenure
$27.99 - $41.98/hr
The Gingery laboratory investigates local and systemic impacts of aging, cellular senescence, immune dysregulation, and metabolic dysfunction in musculoskeletal diseases and conditions. These include ...
The Peng laboratory has been performing translational studies to dissect molecular mechanisms responsible for the senescence and dysfunction of T cells in the tumor microenvironment from different ...
The Peng laboratory has been performing translational studies to dissect molecular mechanisms responsible for the senescence and dysfunction of T cells in the tumor microenvironment from different ...
Senior Research Scientist, High Throughput Biology
Redwood City, CA · On-site
$120K - $153K/yr
Experience with assay technologies highly relevant to aging or age-related disease biology, including senescence assays, mitochondrial function, proteostasis, or longevity pathway readouts.
Senior Research Scientist, High Throughput Biology
Redwood City, CA · On-site
$120K - $153K/yr
Experience with assay technologies highly relevant to aging or age-related disease biology, including senescence assays, mitochondrial function, proteostasis, or longevity pathway readouts.
The Peng laboratory has been performing translational studies to dissect molecular mechanisms responsible for the senescence and dysfunction of T cells in the tumor microenvironment from different ...
The Peng laboratory has been performing translational studies to dissect molecular mechanisms responsible for the senescence and dysfunction of T cells in the tumor microenvironment from different ...
Senescence information
What is senescence in the context of biology?
Senescence refers to the process by which cells or organisms gradually deteriorate with age, leading to a decline in function and increased vulnerability to death. In cells, senescence is a state where cells stop dividing but do not die, often as a response to stress or damage. This process plays a key role in aging and age-related diseases, but it also helps prevent the proliferation of damaged cells, thus protecting against cancer. Understanding senescence is important for research into aging, regenerative medicine, and therapies for age-associated conditions.
What are the key skills and qualifications needed to thrive as a Gerontologist, and why are they important?
To thrive as a Gerontologist, you need expertise in aging processes, research methods, and health sciences, typically supported by a degree in gerontology or a related healthcare field. Familiarity with data analysis software, patient care systems, and knowledge of age-related assessment tools is essential. Compassion, patience, and strong interpersonal communication skills help build trust and support with older adults and their families. These skills ensure effective care, meaningful research, and advocacy for the well-being of the aging population.
What are some common challenges faced by researchers working in the field of senescence biology?
Researchers in senescence biology often encounter challenges such as the complexity of cellular aging mechanisms, variability in senescence markers across cell types, and difficulties in translating laboratory findings into clinical applications. Collaboration with multidisciplinary teams—including bioinformaticians, clinicians, and molecular biologists—is essential to address these challenges. Staying updated with rapidly evolving technologies and methodologies, while managing large data sets, is also a key part of the role.
What is the difference between Senescence vs Cell Biologist?
| Aspect | Senescence | Cell Biologist |
|---|---|---|
| Required credentials | Typically requires a PhD in biology, biochemistry, or related fields | Requires a PhD or master's in biology, cell biology, or related disciplines |
| Work environment | Research labs, biotech companies, academic institutions | Research labs, universities, biotech firms |
| Industry usage | Used in aging research, cancer studies, regenerative medicine | Involved in studying cell functions, mechanisms, and processes |
Senescence refers to the biological process where cells stop dividing and enter a state of growth arrest, often related to aging or stress responses. Cell Biologists study the structure, function, and behavior of cells, including processes like senescence. While senescence is a specific cellular process, cell biologists explore a broad range of cellular functions, making their roles complementary but distinct.
More about Senescence jobs
What cities are hiring for Senescence jobs? Cities with the most Senescence job openings:
What states have the most Senescence jobs? States with the most job openings for Senescence jobs include:
What job categories do people searching Senescence jobs look for? The top searched job categories for Senescence jobs are:
$49K - $67K/yr
Full-time
Medical, Dental, Vision, Retirement
Posted 16 days ago
Mayo Clinic rating
7.9
Based on 682 frontline employees who took The Breakroom Quiz
106th of 874 rated healthcare providers
Job description
The T Cell Engineering Laboratory (Kenderian Laboratory) at Mayo Clinic is seeking a highly motivated and talented Postdoctoral Research Fellow to lead and contribute to the development of next-generation engineered cell therapies for cancer and immune-mediated diseases.
Our laboratory is recognized for its work in CAR T cell biology, synthetic and logic-gated cell therapies, mechanisms of resistance and toxicity, and translational immunotherapy, with a strong emphasis on moving discoveries from bench to clinic. The successful candidate will work in a highly collaborative, well-resourced environment with direct access to GMP manufacturing, clinical trials, and multidisciplinary translational teams.
This position is ideal for individuals aspiring to careers in academic medicine, biotechnology, or translational research leadership. The postdoctoral fellow will have the opportunity to lead independent and collaborative projects in areas including (but not limited to):
- Design and engineering of next-generation CAR T and other engineered immune cell therapies
- Synthetic biology approaches (e.g., logic-gated receptors, synNotch, armored CARs)
- Overcoming tumor immune evasion, antigen loss, exhaustion, and senescence
- Mechanisms of on-target/off-tumor toxicity and immune-related adverse events
- Translational studies bridging preclinical models, GMP manufacturing, and early-phase clinical trials
- Solid and hematologic malignancies, with opportunities for cross-platform innovation
Projects will be tailored to the fellow's expertise and career goals, with strong encouragement and support for first-author high-impact publications and independent funding applications. The laboratory offers a unique translational ecosystem, including:
- State-of-the-art BSL-2+/cell engineering laboratories
- Access to GMP cell manufacturing through the Center for Regenerative Biotherapeutics
- Close interaction with clinician-scientists, immunologists, bioengineers, and industry collaborators
Strong mentoring culture with structured guidance in:
- Grant writing (NIH K99/R00, foundation awards)
- Manuscript preparation for top-tier journals
- Scientific presentation and leadership development
- Career advancement in academia or industry
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.
Equal Opportunity
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.
Required qualifications:
Ph.D., M.D., or M.D./Ph.D. in Immunology, Cancer Biology, Bioengineering, Molecular Biology, or a related field. Strong background in cellular or molecular immunology or cancer biology. Demonstrated productivity with peer-reviewed publications. Excellent written and verbal communication skills. High level of independence, creativity, and scientific rigor.
Preferred qualifications: (not required)
Experience with T cell biology, CAR T cell engineering, or adoptive cell therapy. Expertise in one or more of the following:
- Viral or non-viral gene delivery
- Flow cytometry and immune phenotyping
- CRISPR/Cas9 or genetic engineering
- In vivo mouse models
- Synthetic biology platforms
- Interest in translational or clinically oriented research
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About Mayo Clinic
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Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.
Industry
Hospitals
Company size
10,000+ Employees
Headquarters location
Rochester, MN, US
Year founded
1919