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Remote Senior Software Engineer Jobs in Nebraska

micro1 AI

Bioinformatics Software Engineer

Lincoln, NE · Remote

$80 - $110/hr

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

Harris

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

In this role, you will directly contribute to that mission by ensuring our software provides a ... This remote role welcomes candidates anywhere in Canada and the US. Travel is required as needed ...

Harris

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

In this role, you will directly contribute to that mission by ensuring our software provides a ... This remote role welcomes candidates anywhere in Canada and the US. Travel is required as needed ...

Mutual of Omaha

AI Engineer - Remote

Omaha, NE · Remote

  • Retirement

  • PTO

Nebraska, Remote Categories: Information Technology Mutual Of Omaha is seeking an experienced ... Extensive experience applying software engineering design patterns and enterprise application ...

TELCOR Inc

Forward Deployed Engineer

Lincoln, NE · On-site +1

$125K - $165K/yr

Forward Deployed Engineer TELCOR Inc, a leading innovator in laboratory software, is looking for a ... remote. Copy and paste the following link into your browser to learn more about TELCOR and what it ...

Kiewit Corporation

Sr AI Engineer

Papillion, NE · On-site +1

$98K - $135K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Senior Level Home District/Group: DHO Information Technology Group Department: Technology Group ... Experience mentoring engineers and delivering complex production software Preferred Qualifications

Xage Security

Senior Backend Engineer

Lincoln, NE · Remote

  • Medical

  • Dental

  • Vision

... Remote Access Named in Forrester research on Operation Technology Security Solutions, and ... Requirements * 3+ years of experience in software development using HTTP/s proxies, Websockets ...

Buildertrend

Forward Deployed AI Engineer

Omaha, NE · On-site +1

$200K - $250K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

United States - Remote or Omaha, NE - Hybrid The job: As a Forward Deployed AI Engineer at ... Who you are and what you need: * 5+ years of software engineering experience, including at least 2 ...

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All JobsSoftware Engineer JobsRemote Senior Software Engineer JobsRemote Senior Software Engineer Jobs in Nebraska

Remote Senior Software Engineer information

See Nebraska salary details

$72K

$136.6K

$183.1K

How much do remote senior software engineer jobs pay per year?

As of Aug 12, 2026, the average yearly pay for remote senior software engineer in Nebraska is $136,621.00, according to ZipRecruiter salary data. Most workers in this role earn between $116,800.00 and $154,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a remote senior software engineer, and why are they important?

To thrive as a Remote Senior Software Engineer, you need deep expertise in software development, architecture, and problem-solving, typically supported by a degree in computer science and several years of professional programming experience. Proficiency with version control systems (like Git), cloud platforms (such as AWS or Azure), and familiarity with CI/CD pipelines and relevant certifications are highly valued. Excellent communication, self-motivation, and time management skills help you excel in remote, cross-functional teams. These skills ensure you can deliver high-quality solutions, collaborate effectively, and lead complex projects independently.

What does a remote senior software engineer do?

As a remote senior software engineer, your job is to code, test, and debug computer software applications for your employer. In this role, you may test the deployment of software within your network, ensure it functions properly on each operating system, choose which programming language to use, and help manage the development process. Senior software engineers frequently guide and review work from junior software engineers, determine how to translate business requirements into technical specifications, and provide input on hiring decisions relevant to the company's programming needs. Remote senior software engineers do all of this work from home or from a personal office. You use phones, email, text, and virtual office software to stay in touch with other employees.

What is a senior software engineer remote?

A senior software engineer job is a remote, high-level position that involves programming code and software. You work from home and telecommunicate with other IT support staff. A senior software engineer can work on various systems, but your duties are similar. Your responsibilities are to develop, test, and debug code. You may also build, update, or manage a software network. A software engineering professional often works on the entire development life cycle and must find and correct issues quickly and efficiently.

What does a remote senior software engineer do?

A Remote Senior Software Engineer designs, develops, and maintains complex software systems while working from a location outside of the traditional office. They often lead development teams, set technical direction, review code, and mentor junior engineers. Their responsibilities include collaborating with cross-functional teams, ensuring code quality, and implementing best practices in software development. Remote Senior Software Engineers use various communication and project management tools to stay connected with their teams and deliver high-quality software solutions efficiently.

What is the difference between Remote Senior Software Engineer vs Remote Software Developer?

AspectRemote Senior Software EngineerRemote Software Developer
Required CredentialsBachelor's degree in CS or related field, 5+ years experience, advanced coding skillsBachelor's degree or equivalent, 1-3 years experience, strong coding skills
Work EnvironmentCollaborates on complex projects, mentors junior staff, involved in architecture decisionsFocuses on coding, testing, and implementing features, less mentorship
Employer & Industry UsageTech companies, startups, enterprise software firmsStartups, tech firms, freelance projects

The Remote Senior Software Engineer typically has more experience, handles complex tasks, and mentors others, whereas the Remote Software Developer focuses on coding and implementing features with less leadership responsibility.

What are some common challenges faced by remote senior software engineers and how can they be addressed?

Remote Senior Software Engineers often face challenges such as maintaining effective communication across different time zones, ensuring strong collaboration with distributed teams, and staying aligned with project goals. Proactively scheduling regular check-ins, utilizing collaboration tools like Slack or Jira, and setting clear expectations can help overcome these hurdles. Additionally, building strong documentation habits and fostering relationships through virtual meetings can enhance teamwork and project success.
More about Remote Senior Software Engineer jobs
What are popular job titles related to Remote Senior Software Engineer jobs in Nebraska? For Remote Senior Software Engineer jobs in Nebraska, the most frequently searched job titles are:
What job categories do people searching Remote Senior Software Engineer jobs in Nebraska look for? The top searched job categories for Remote Senior Software Engineer jobs in Nebraska are:
What cities in Nebraska are hiring for Remote Senior Software Engineer jobs? Cities in Nebraska with the most Remote Senior Software Engineer job openings:
Remote Senior Software Engineer jobs near you
Infographic showing various Remote Senior Software Engineer job openings in Nebraska as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% Remote job distribution, with an average salary of $136,621 per year, or $65.7 per hour.

Bioinformatics Software Engineer

micro1 AI

Lincoln, NE • Remote

$80 - $110/hr

Part-time

Posted 10 days ago

Job description

Role Title: Computational Biology & Cheminformatics Expert


Role Type: Contractor


Location: Remote


micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer’s computational drug discovery project. In this role, you'll apply your expertise to help train next-generation AI systems. Your work will shape how models learn, reason, and perform through high-quality, real-world input. No prior experience in AI is required — your domain knowledge is what matters.


Scope of Work

  1. Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods.
  2. Curate, annotate, and validate chemical and biological datasets (e.g., ChEMBL, PubChem, DrugBank) to support AI-driven discovery platforms.
  3. Evaluate compound-target interactions, ADMET properties, and lead optimization strategies by integrating chemical, biological, and clinical data sources.
  4. Provide expert insights on structure-activity and structure-property relationships (SAR/SPR), medicinal chemistry approaches, and experimental design considerations.
  5. Build and implement code-based benchmark tasks (e.g., terminal/CLI-based environments) that reflect realistic computational drug discovery scenarios.
  6. Develop reproducible environments (e.g., using Docker) and automated testing pipelines to ensure task correctness and solvability.
  7. Assess and review AI-generated outputs for scientific rigor, accuracy, and practical relevance, delivering detailed written feedback and recommendations.


Preferred Qualifications

  1. Advanced expertise in Computational Biology, Cheminformatics, Medicinal Chemistry, Biochemistry, or related fields; advanced degree (PhD, MSc, PharmD) highly valued but not strictly required.
  2. Strong coding proficiency in Python (beyond analysis scripts), with hands-on experience building tools, pipelines, or testable code; familiarity with Git, GitHub, and Docker.
  3. Extensive experience with cheminformatics toolkits and platforms such as RDKit, KNIME, Schrödinger, OpenEye, or MOE.
  4. Proven track record in small-molecule drug discovery, SAR/QSAR evaluation, ADMET prediction, or virtual screening workflows.
  5. Comfort working with public chemical and bioactivity databases and integrating diverse datasets for scientific analysis.
  6. Demonstrated ability to clearly communicate complex chemical and biological concepts in written feedback and reports.
  7. Experience participating in multidisciplinary and/or remote projects; familiarity with AI-assisted coding tools is a plus.

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