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Remote Prompt Engineer Jobs in Massachusetts (NOW HIRING)

As a remote-first organization headquartered in St. Petersburg, Florida, Kobie values meaningful in ... Implement guardrails around tool execution: auth scoping, input/output validation, PII and prompt ...

Backend Engineer/FullStack

Cambridge, MA · On-site +1

$140K - $220K/yr

Exposure to LLM-driven systems (prompt management, caching, streaming) * Experience with Docker ... Remote work stipend * Generous PTO Next Steps If you're interested in working on challenging ...

Senior Project Engineer

Weston, MA · On-site +1

$75K - $182K/yr

Provide accurate and prompt responses to RFIs and submittal reviews. * Support continuous ... Particularly working with people remote to you either in the field or a remote office. * Team first ...

Data Engineer with AI - Remote

Boston, MA · On-site +1

$124K - $149K/yr

Data Engineer + AI Work location : Boston, MA Duration: 12 Months Job Summary: We're looking for a ... prompt/response logging). * Cloud proficiency on AWS/Azure/GCP (object storage, IAM, networking)

This is a fully remote position. The program runs approximately 6 months. WHAT YOU'LL DO: * Build ... Prior hands-on experience with LLMs, prompt engineering, or agentic frameworks (LangGraph, CrewAI ...

This is a fully remote position. The program runs approximately 6 months. WHAT YOU'LL DO: * Build ... Prior hands-on experience with LLMs, prompt engineering, or agentic frameworks (LangGraph, CrewAI ...

Guidewire Developer-ClaimCenter

Boston, MA · On-site +1

$59.25 - $78.25/hr

... TX, Remote-CT, Remote-GA, Remote-IL, Remote-IN, Remote-OH, Remote-PA, Remote-TX, Remote-VA ... AI Prompt/Agentic Engineering * Monitoring and logging via tools like AppDynamics and Splunk

Sr. Developer

Boston, MA · On-site +1

$131K - $160K/yr

Advanced proficiency in prompt engineering to design complex AI solutions, ensuring output ... remote employees. Our customers are some of the world's most recognizable brands across diverse ...

Showing results 21-40

Remote Prompt Engineer information

See Massachusetts salary details

$14

$61

$88

How much do remote prompt engineer jobs pay per hour?

As of Aug 15, 2026, the average hourly pay for remote prompt engineer in Massachusetts is $61.15, according to ZipRecruiter salary data. Most workers in this role earn between $43.85 and $81.39 per hour, depending on experience, location, and employer.

What is a remote prompt engineer?

A Remote Prompt Engineer designs, refines, and optimizes prompts to improve interactions between users and AI models. They work with natural language processing (NLP) systems to enhance response accuracy and relevance. This role often involves testing different prompts, analyzing AI outputs, and collaborating with developers or researchers to fine-tune language models. Since the position is remote, engineers use online tools and communication platforms to collaborate with teams and stay updated on AI advancements.

What does a typical workday look like for a remote prompt engineer?

As a Remote Prompt Engineer, your workday often involves designing and testing prompts for various AI models, collaborating with product managers and developers, and analyzing model outputs to refine interactions. You may also participate in virtual team meetings to discuss project goals, provide feedback on AI performance, and stay updated on new advancements in prompt engineering. Routine responsibilities include documenting prompt structures, troubleshooting model behavior, and integrating feedback from client or user testing. This dynamic and collaborative environment enables you to contribute creative solutions and drive continuous improvement in AI-driven applications.

What are the key skills and qualifications needed to thrive as a remote prompt engineer?

To thrive as a Remote Prompt Engineer, you need expertise in natural language processing, prompt design, and a background in computer science or a related field. Familiarity with AI platforms (such as OpenAI or Anthropic APIs), programming languages like Python, and prompt engineering tools is highly valuable. Outstanding communication, collaboration, and problem-solving skills help remote team members excel in optimizing AI performance. These competencies ensure tailored, effective AI solutions and smooth, results-driven teamwork from a remote environment.

What are the most commonly searched types of Prompt Engineer jobs in Massachusetts?

The most popular types of Prompt Engineer jobs in Massachusetts are:

What are popular job titles related to Remote Prompt Engineer jobs in Massachusetts?

For Remote Prompt Engineer jobs in Massachusetts, the most frequently searched job titles are:

What job categories do people searching Remote Prompt Engineer jobs in Massachusetts look for?

The top searched job categories for Remote Prompt Engineer jobs in Massachusetts are:

What cities in Massachusetts are hiring for Remote Prompt Engineer jobs?

Cities in Massachusetts with the most Remote Prompt Engineer job openings:

Infographic showing various Remote Prompt Engineer job openings in Massachusetts as of August 2026, with employment types broken down into 92% Full Time, and 8% Contract. Highlights an 100% Remote job distribution, with an average salary of $127,192 per year, or $61.1 per hour.

Principal Software Engineer

eClinical Solutions

Mansfield, MA • On-site, Remote

$142K - $191K/yr

Full-time

Re-posted 9 days ago


Job description

About eClinical Solutions
eClinical Solutions is transforming clinical development with elluminate®, our Clinical Data Cloud, helping life sciences organizations unify, analyze, and unlock the value of their data faster than ever before. By combining a modern cloud platform with expert data services, we empower smarter decisions across the clinical trial lifecycle-accelerating innovation that ultimately improves patient outcomes.
Our engineering teams build enterprise-grade, revenue-generating products at the intersection of cloud, data, analytics, and emerging AI technologies. If you're excited about building sophisticated software that makes a real-world impact on healthcare, this is the place to do it.
You will make an impact:
As a Principal Full Stack Software Engineer, you will be a technical leader within the elluminate Product Development team. You'll help design and build the core services and user experiences of a next-generation clinical data and analytics platform-while influencing architecture, engineering standards, and technical direction.
This role is ideal for an experienced engineer who enjoys hands-on development, mentoring others, and bringing modern capabilities-including AI-assisted and agentic workflows-into production-grade systems.
Your day to day:
  • Design, develop, test, and deploy scalable, secure, and highly interactive web applications
  • Own and evolve core platform modules, from concept through release and support
  • Influence application and system architecture with a focus on performance, reliability, security, and maintainability
  • Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
  • Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
  • Provide technical mentorship and guidance to other engineers on the team
  • Diagnoses and resolves complex production issues across distributed systems
  • Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
  • Contribute to technical documentation including design specs, acceptance criteria, and release notes

AI & Modern Engineering Focus
We're actively incorporating AI-powered capabilities into our platform, and you'll help shape how this is done responsibly and effectively in an enterprise environment. This includes:
  • Integrating LLMs and AI services into .NET- and Python-based systems
  • Designing and implementing AI-assisted workflows, copilots, or intelligent automation features
  • Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation)
  • Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance
  • Collaborating with data and platform teams to operationalize AI-not just prototype it

Deep ML expertise is not required-we're looking for strong engineers who understand how to apply AI capabilities in real products.
Take the first step toward your dream career. Here is what we are looking for in this role.
Qualifications:
  • Bachelor's or Master's degree in Computer Science or equivalent practical experience
  • 10+ years in software design and development using the Microsoft technology stack preferred
  • Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
  • Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
  • Solid understanding of software design principles, patterns, and best practices
  • Experience across the full Software Development Lifecycle (Agile preferred)
  • Proven ability to work independently while collaborating effectively in a fast-paced environment
  • Excellent communication, documentation, and technical leadership skills

AI & Platform Experience
  • Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
  • Experience using Python and/or .NET alongside AI/LLM workflows
  • Familiarity with agent-based or workflow-driven AI architectures is a strong plus
  • Understanding of secure and responsible AI usage in enterprise systems

Nice to Have
  • Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
  • Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
  • Secure development experience, including awareness of common vulnerabilities and mitigations
  • Experience with clinical trial data, life sciences, or regulated SaaS environments
  • Experience building data visualizations or analytics-driven user experiences

Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours!
eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here: https://topworkplaces.com/company/eclinical-solutions/
eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here!
We are proud to be an equal opportunity employer that values diversity. Our management team is committed to the principle that employment decisions are based on qualifications, merit, culture fit and business need.
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Pay Range
US Pay Ranges
$152,000-$190,000 USD