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Remote Infrastructure Security Engineer Jobs in California

DocuSign

Security Engineer

San Francisco, CA · On-site +1

What you'll do As a Security Engineer on the Cloud & Infrastructure Security team, you will support ... Employee divides their time between in-office and remote work. Access to an office location is ...

Stripe

Security Engineer

South San Francisco, CA · On-site +1

$194K - $268K/yr

Who we are About Stripe Stripe is a financial infrastructure platform for businesses. Millions of ... Full remote work permitted. Multiple Positions Available. Additional benefits for this role may ...

Stripe

Security Engineer

South San Francisco, CA · On-site +1

$194K - $268K/yr

Who we are About Stripe Stripe is a financial infrastructure platform for businesses. Millions of ... Full remote work permitted. Multiple Positions Available. Additional benefits for this role may ...

Stripe

Security Engineer

South San Francisco, CA · On-site +1

$194K - $268K/yr

Who we are About Stripe Stripe is a financial infrastructure platform for businesses. Millions of ... Full remote work permitted. Multiple Positions Available. Additional benefits for this role may ...

Figma

Security Engineer

San Francisco, CA · Remote

This is a remote first role. You will partner closely with teams across the company and focus on ... Advocate for secure practices across Figma's AI infrastructure, platforms, and data systems.

Figma

Security Engineer

San Francisco, CA · Remote

This is a remote first role. You will partner closely with teams across the company and focus on ... Advocate for secure practices across Figma's AI infrastructure, platforms, and data systems.

Red Cup IT Inc

Security Engineer

Los Angeles, CA · On-site +1

We are looking for a Security Engineer who is responsible for design, implement, and maintain ... Key Responsibilities • Security Infrastructure Management: Design and deploy firewalls, intrusion ...

SpaceX

Security Engineer

Hawthorne, CA · On-site +1

$150K - $180K/yr

Network security systems and the backend infrastructure that powers such services. * Application ... Hybrid or remote work will not be considered. * Ability to pass Air Force background check for Cape ...

SpaceX

Security Engineer

Hawthorne, CA · On-site +1

$150K - $180K/yr

Network security systems and the backend infrastructure that powers such services. * Application ... Hybrid or remote work will not be considered. * Ability to pass Air Force background check for Cape ...

You.com

Senior Security Engineer

San Francisco, CA · On-site +1

$180K - $235K/yr

About Us At You.com, we are building the AI Search Infrastructure that powers modern AI systems ... hybrid/remote team's cell phone and internet expenses* * $1,200 per year Health & Wellness ...

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All JobsRemote Infrastructure Security Engineer JobsRemote Infrastructure Security Engineer Jobs in California

Remote Infrastructure Security Engineer information

See California salary details

$73K

$140.3K

$167.8K

How much do remote infrastructure security engineer jobs pay per year?

As of Jun 10, 2026, the average yearly pay for remote infrastructure security engineer in California is $140,272.00, according to ZipRecruiter salary data. Most workers in this role earn between $141,100.00 and $141,100.00 per year, depending on experience, location, and employer.

What is a Remote Infrastructure Security Engineer?

A Remote Infrastructure Security Engineer is a cybersecurity professional who is responsible for protecting an organization's IT infrastructure, such as servers, networks, and cloud services, from security threats. They work remotely, using specialized tools to monitor systems, detect vulnerabilities, and respond to incidents. Their duties often include implementing firewalls, managing access controls, and ensuring compliance with security standards. These engineers play a crucial role in maintaining the safety and integrity of digital assets while supporting teams from any location.

What are the key skills and qualifications needed to thrive as a Remote Infrastructure Security Engineer, and why are they important?

To thrive as a Remote Infrastructure Security Engineer, you need a solid background in cybersecurity, network architecture, and systems administration, often supported by a relevant degree and certifications like CISSP or CompTIA Security+. Familiarity with security tools such as firewalls, intrusion detection/prevention systems (IDS/IPS), SIEM solutions, and cloud security platforms is essential. Strong analytical thinking, effective communication, and the ability to work independently are standout soft skills in this role. These skills and qualifications are crucial to proactively protect organizational infrastructure, rapidly respond to threats, and ensure secure remote operations.

What is the difference between Remote Infrastructure Security Engineer vs Network Security Engineer?

AspectRemote Infrastructure Security EngineerNetwork Security Engineer
CertificationsCompTIA Security+, CISSP, CEHCompTIA Security+, CISSP, CCNP Security
Work EnvironmentCloud-based infrastructure, remote teamsOn-premises and cloud networks, often remote
Industry UsageTech, finance, healthcare, remote-first companiesTelecom, enterprise, government agencies
Common Search/ComparisonYesYes

The Remote Infrastructure Security Engineer focuses on securing cloud and remote infrastructure environments, while the Network Security Engineer specializes in protecting network hardware and on-premises or cloud networks. Both roles require similar certifications and often work remotely, but their primary focus areas differ, aligning with different aspects of cybersecurity infrastructure.

How does a Remote Infrastructure Security Engineer typically collaborate with other IT teams to ensure system security?

As a Remote Infrastructure Security Engineer, collaboration with various IT teams is integral to maintaining a secure environment. You'll often work closely with network administrators, system engineers, and DevOps teams to assess vulnerabilities, implement security controls, and respond to incidents. Regular virtual meetings, shared documentation platforms, and ticketing systems are commonly used to coordinate efforts and ensure everyone is aligned on security protocols. This collaborative approach helps proactively address risks and ensures compliance with organizational security standards.
What are popular job titles related to Remote Infrastructure Security Engineer jobs in California? For Remote Infrastructure Security Engineer jobs in California, the most frequently searched job titles are:
What job categories do people searching Remote Infrastructure Security Engineer jobs in California look for? The top searched job categories for Remote Infrastructure Security Engineer jobs in California are:
What cities in California are hiring for Remote Infrastructure Security Engineer jobs? Cities in California with the most Remote Infrastructure Security Engineer job openings:
Remote Infrastructure Security Engineer jobs near you

Principal Security & Infrastructure Engineer

Profluent

Emeryville, CA • On-site, Remote

$165K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 15 days ago

Job description

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.
Profluent is seeking a Principal Infrastructure & Security Engineer to serve as the primary owner of Profluent's security posture across scientific systems, lab automation environments, cloud and business infrastructure, endpoints, identity systems, and core operational workflows.
This person will be accountable for the design, implementation, operation, and continuous improvement of the technical controls, security standards, and operating practices that protect Profluent's systems and data. This includes security architecture, access controls, hardening, monitoring, incident readiness, vendor and customer security assurance, and the systems and evidence required to achieve and maintain compliance commitments.
This is not a narrow compliance-only or infrastructure-only role. It is a broad ownership role for security across Profluent's environments, with close partnership across Operations, Machine Learning, Bioinformatics, and Lab Automation.
Responsibilities
  • Own Profluent's overall security and compliance posture across company systems, scientific computing, lab automation, endpoints, identity, SaaS, cloud infrastructure, networking, and data-handling workflows, and be accountable for the ongoing maturity of security controls and practices across those environments
  • Lead the implementation and operational maturity work required for Profluent to achieve and maintain SOC 2 and related compliance certification requirements, including control operation, evidence collection, monitoring, and repeatable processes
  • Serve as the primary owner for security and compliance readiness across company systems, ensuring that Profluent can meet ongoing audit, certification, and customer assurance requirements over time
  • Own the translation of customer agreements, internal policies, and compliance requirements into concrete technical and operational controls
  • Standardize and harden bioinformatics, lab informatics, and machine learning environments to align with security, reliability, and compliance requirements
  • Define and drive adoption of secure baseline configurations, access controls, logging, backup practices, patching standards, and change management processes
  • Own and evolve how Profluent approaches security more broadly, identifying gaps, prioritizing risks, and driving improvements beyond minimum compliance scope
  • Drive standardization of Windows-based lab automation environments, balancing security, uptime, vendor constraints, and usability in laboratory settings
  • Collaborate with stakeholders to document controls, system boundaries, standard operating procedures, and technical evidence needed for audits, certification efforts, and customer reviews
  • Support vendor and platform evaluations related to security, observability, endpoint management, and infrastructure operations
  • Improve identity, access, and account lifecycle management across company systems, including onboarding, offboarding, least-privilege access, and periodic access review support
  • Monitor key systems and respond to operational issues with an emphasis on root-cause analysis and durable remediation
  • Maintain asset, system, and environment documentation so that critical processes are auditable, supportable, and repeatable

Qualifications
  • Experience operating with broad ownership across infrastructure, security, and compliance in regulated, audit-conscious, or security-sensitive environments
  • Experience serving as the most senior or primary security owner in a startup or scaling environment, even without a large dedicated security team
  • Breadth across infrastructure security, corporate security, IAM, endpoint management, logging and monitoring, vulnerability reduction, incident response, vendor risk, and compliance
  • Demonstrated ability to take ownership in ambiguous environments and set direction, not just execute within a narrowly defined specialty
  • Familiarity with Windows-based lab automation systems and the realities of instrument-connected or vendor-managed environments
  • Experience implementing or operating against security and compliance frameworks such as SOC 2, ISO 27001, NIST CSF, or similar
  • Strong understanding of identity and access management, SSO, MFA, endpoint management, logging, patching, vulnerability reduction, and system hardening
  • Ability to translate compliance and contractual data-handling requirements into concrete technical and operational controls
  • Strong documentation skills, with the ability to create policies, procedures, standards, and technical runbooks that others can follow
  • Experience preparing organizations for, achieving, or maintaining external compliance certifications or audit readiness
  • Experience with infrastructure as code and/or configuration management tools such as Terraform, Ansible, or equivalent
  • Experience administering Windows environments, preferably including systems used in laboratory, automation, manufacturing, or instrument-connected settings

Preferences (but not required)
  • Familiarity with audit evidence preparation, control testing, and coordination with external auditors
  • Familiarity with networking fundamentals including firewalls, routing, VLANs, NAT, VPNs, and secure remote access
  • Experience influencing cross-functional teams and improving organizations mature security practices without relying on rigid bureaucracy

What We Offer
  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.
Work Authorization Requirement
Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.
Employment Eligibility Verification
Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.
Hiring Salary Range
$175,000-$250,000 USD

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