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Guardant's HPC team builds and operates the computational technology backbone of the company. This includes scalable data storage that holds petabytes of genomics data, high-performance compute clusters running a custom bioinformatics pipeline in production and R&D environments, and the software infrastructure that hosts an ecosystem of services for internal data processing and external data integration.

The HPC engineering team is looking for a Staff-level engineer with broad, all-round HPC competency and specialized depth in one or more of the following: Red Hat-family OS management, networking, storage, Kubernetes, or Slurm. Experience applying these skills both on-premise and in the cloud is a plus, as we continue to evolve our HPC footprint. This role carries technical depth and cross-team representation for HPC compute, networking, and storage-integration initiatives, partnering closely with our engineering team and our managed service provider (MSP) as we scale operations. To support Guardant Health's fast growth over the next few years, we need a strong technical engineer who can help maintain and grow the HPC infrastructure through this expansion while working closely with corporate IT, SQA, and DevOps/SRE teams. Strong teamwork and the ability to manage multiple in-flight, cross-functional projects at once are essential for success in this role.

About the Role

You enjoy an agile, very fast paced and highly technical environment. You are a self-driven, accomplished technologist who strives to continually improve your skills as the HPC landscape evolves and the computational infrastructure scales. You are dedicated to engineering excellence yet pragmatic and flexible. You have the ability to maintain the day-to-day support SLA while running various key projects that move the business forward. You are comfortable being the deepest technical voice in the room on your declared specialism, even among more senior colleagues, while operating as a peer to the other engineers on the team.

Essential Duties and Responsibilities

Broad HPC Skills (all-round)

Manage multiple HPC clusters and cluster file systems

Integrate cloud bursting as part of the HPC abstraction work

Research, develop, and implement the next generation HPC solutions

Troubleshoot the production system stack down to source code level, e.g shell scripts, Python, and others

Maintain, monitor, and support the infrastructure environment and/or facilities

Use and maintain enhanced production monitoring and addition capability

Support improvements for increased system reliability and performance

Support multiple systems or applications of medium to high complexity complexity defined by size, technology used, and system feeds and interfaces) with multiple concurrent users, ensuring control, integrity, and accessibility

Support systems at remote locations, including internationally

Mentor junior engineers on HPC best practices

Work with offsite consultants to maintain the infrastructure

Work with vendors to troubleshoot, upgrade, and repair systems as needed

Represent HPC infrastructure networking and storage-integration topics in cross-functional planning with networking, SQA, DevOps/SRE, and the MSP

Set up and ownership supporting XDMoD instances for HPC metric and monitoring

Participate in a 24/7 on-call rotation

Networking

Act as the technical peer for HPC networking and interconnect initiatives with the dedicated networking engineer

Collaborate on design, performance tuning, and troubleshooting of HPC Ethernet

Work with enterprise networking on integration of HPC systems with the bandwidth-on-demand system that connects our sites and cloud infrastructure

Work with the networking infrastructure team to manage and optimize connectivity to and from HPC systems and global locations

Storage

Act as the technical peer for the architecture and integration strategy for. HPC storage in partnership with the dedicated storage engineer and MSP

Serve as a technical point of contact for the MSP storage relationship and help define and evolve SLAs, validate delivery, and escalate technical issues

Support the transition of day-to-day storage operations to the MSP without loss of performance or reliability

Employee may be required to lift routine office supplies and use office equipment.Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment.Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out toPeopleteam@guardanthealth.com

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.
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