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Python Software Engineer Jobs in Missouri (NOW HIRING)

Merck Group

Staff Software Engineer

Saint Louis, MO · On-site

$110K - $165K/yr

This role is software engineering first, with a strong emphasis on designing reliable systems that ... Design, develop, and maintain scalable Python applications and backend services. * Build systems ...

Merck KgaA

Staff Software Engineer

Saint Louis, MO · On-site

$110K - $165K/yr

This role is software engineering first, with a strong emphasis on designing reliable systems that ... Design, develop, and maintain scalable Python applications and backend services. * Build systems ...

Danaher

Writing and debugging code in languages such as C#, Java, Python, or C++ * Participating on an ... Software Engineering, Biomedical Engineering (with computational focus), or related field

Danaher

Writing and debugging code in languages such as C#, Java, Python, or C++ * Participating on an ... Software Engineering, Biomedical Engineering (with computational focus), or related field

Danaher

Software Engineer Internships

Columbia, MO · On-site

Writing and debugging code in languages such as C#, Java, Python, or C++ * Participating on an ... Software Engineering, Biomedical Engineering (with computational focus), or related field

Danaher

Writing and debugging code in languages such as C#, Java, Python, or C++ * Participating on an ... Software Engineering, Biomedical Engineering (with computational focus), or related field

Danaher

Writing and debugging code in languages such as C#, Java, Python, or C++ * Participating on an ... Software Engineering, Biomedical Engineering (with computational focus), or related field

Danaher

Writing and debugging code in languages such as C#, Java, Python, or C++ * Participating on an ... Software Engineering, Biomedical Engineering (with computational focus), or related field

Omni Federal

Software Engineer

Saint Louis, MO · On-site

Job Title: Software Engineer Location: St. Louis, MO Security Clearance: Active TS/SCI (or SCI ... Hands-on experience with Python in production application development environments or building ...

Jobtailor

Software Engineer, ML Platform

California, MO · On-site

$140 - $200/hr

Proficiency in Python, Ruby, or Java * Experience designing and developing machine learning ... Software Engineering * Emerging AI Frameworks Soft Skills * Curiosity * Experimentation Industry ...

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Python Software Engineer information

See Missouri salary details

$21.6K

$131.3K

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How much do python software engineer jobs pay per year?

As of Aug 19, 2026, the average yearly pay for python software engineer in Missouri is $131,293.00, according to ZipRecruiter salary data. Most workers in this role earn between $103,600.00 and $154,300.00 per year, depending on experience, location, and employer.

What is a Python software engineer?

A Python Software Engineer is a developer who designs, develops, and maintains software applications using the Python programming language. They work on a variety of tasks, including writing clean and efficient code, debugging, optimizing performance, and integrating third-party services or APIs. Python engineers often collaborate with teams to build web applications, data pipelines, machine learning models, or automation scripts, depending on the industry. Their role requires strong problem-solving skills and familiarity with software development best practices.

What does a Python software engineer do?

A typical workday for a Python Software Engineer involves writing and testing code, participating in team meetings to plan and review tasks, and collaborating with colleagues such as front-end developers, quality assurance engineers, and project managers. You may spend time troubleshooting bugs, reviewing pull requests, and improving existing software modules. Many teams use Agile or Scrum methodologies, so your day may include short stand-up meetings and iterative development cycles. Depending on the company, you might also have opportunities to contribute to design discussions or mentor junior developers.

What skills and qualifications are needed to be a Python software engineer?

To thrive as a Python Software Engineer, you need strong programming skills in Python, a solid understanding of algorithms and data structures, and a relevant degree in computer science or related fields. Experience with frameworks like Django or Flask, familiarity with version control systems such as Git, and optional certifications like PCEP or PCAP can be valuable assets. Problem-solving skills, teamwork, and effective communication help you navigate complex projects and collaborate efficiently. Mastering both technical and soft skills is crucial for building reliable software solutions and succeeding in dynamic development teams.

Are Python Software Engineers in demand?

Python Software Engineers are in high demand across various industries due to Python's versatility in web development, data analysis, machine learning, and automation. Employers seek professionals with strong programming skills, experience with frameworks like Django or Flask, and knowledge of data tools, making it a valuable skill set for many tech roles.

Can I be a Python Software Engineer with Python?

Yes, Python is the primary programming language used by Python Software Engineers. Proficiency in Python, along with knowledge of related tools like version control systems and frameworks, is essential for this role. Typically, a bachelor's degree in computer science or a related field and experience with software development are also required.

How much do Python software engineers make?

Python software engineers' salaries vary based on experience, location, and industry, but the median annual salary in many regions ranges from $80,000 to $130,000. Senior roles or those with specialized skills in frameworks like Django or data analysis can earn higher compensation, often exceeding $150,000 annually.

What are the most commonly searched types of Python Software Engineer jobs in Missouri?

The most popular types of Python Software Engineer jobs in Missouri are:

What are popular job titles related to Python Software Engineer jobs in Missouri?

For Python Software Engineer jobs in Missouri, the most frequently searched job titles are:

What job categories do people searching Python Software Engineer jobs in Missouri look for?

The top searched job categories for Python Software Engineer jobs in Missouri are:

What are popular job titles related to Python Software Engineer jobs in MO?

For Python Software Engineer jobs in MO, the most frequently searched job titles are:

Python Software Engineer jobs near you
Infographic showing various Python Software Engineer job openings in Missouri as of August 2026, with employment types broken down into 1% As Needed, 84% Full Time, 10% Part Time, and 5% Contract. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $131,293 per year, or $63.1 per hour.

Software Engineer

Reinventing Geospatial, Inc. (RGi)

Saint Louis, MO • On-site

Full-time

Medical, Dental, Retirement, PTO

Re-posted 22 days ago

Job description

Reinventing Geospatial (RGi) is a leading expert in geospatial solutions for Defense, Intelligence, and Federal clients. We enhance situational awareness for soldiers and analysts by integrating software development with geospatial intelligence. Our projects range from data collection to advanced deep learning, leveraging tools like Python, Java, and ArcGIS.
We don't just fill roles we build teams of high performers and leaders who make an immediate impact. At our core, we're driven by innovation and powered by people who work at the intersection of passion and performance. Here, you'll collaborate with bold thinkers, leverage cutting edge technology, and tackle meaningful challenges from day one.
Our culture is defined and anchored by three pillars:
Energy: We bring passion, purpose, and urgency to our work.
Edge: We take initiative, embrace growth, and step outside our comfort zone.
Execution: We get things done smartly, decisively, and with real results.
If you're the kind of person who leads with initiative, thrives in a fast-paced environment, and is eager to create real impact, we want you on our team.
Clearance:
Active Top Secret clearance with an ability to obtain SCI access and willingness to obtain CI Polygraph
US Citizenship Required
As a Software Engineer, you will...
  • Lead full-stack software development of enterprise applications and services supporting our customer's GEOINT mission.
  • Design and implement secure, scalable microservices in cloud environments such as AWS GovCloud or C2S.
  • Guide and mentor junior and mid-level engineers, enforce code quality, and lead peer reviews.
  • Build and deploy applications using DevSecOps pipelines, container orchestration, and Infrastructure-as-Code tools.
  • Collaborate with cross-functional teams including analysts, UI/UX designers, DevOps engineers, and product owners.
  • Translate mission requirements into technical implementations that meet security, performance, and scalability needs.
  • Ensure compliance with our customer and IC cybersecurity and accreditation standards (e.g., RMF, STIGs).

Software Engineer Qualifications...
  • Bachelor's degree in Computer Science, Software Engineering, or related field and 6+ years experience.
  • Strong proficiency with: HTML, CSS, JSON, Ajax, and REST APIs
  • Object-oriented Programming: Python, Java, or JavaScript and Go
  • Front-end and Back-end Frameworks: React, Angular, Vue.js, jQuery, Spring Boot, Django, Node.js, Flask, or Svelte.
  • A strong working knowledge of: AWS, Azure, or similar cloud platforms, MySQL, PostgreSQL, or SQL Server
  • Hands on experience with: Windows, Linux, Git
  • Deep understanding of modern software design patterns and coding standards.
  • Experience architecting, developing, and delivering complex software systems into production.
  • Hands on experience developing containerized applications with Docker and Kubernetes.
  • Experience deploying to and developing in classified cloud environments (e.g., C2S, AWS GovCloud).
  • Familiarity with DevSecOps tools and practices (e.g., GitLab CI/CD, Jenkins, SonarQube, Nexus, Terraform).
  • Solid understanding of Agile methodologies and secure software lifecycle principles.
  • Strong, self-motivated desire to learn new programming languages, tools, frameworks, and techniques.

Additional Skills We'd Like to See:
  • Frontend Web Development: UI/UX
  • NoSQL Database: OpenSearch/Elasticsearch.
  • Cloud Exposure: AWS, IBM, Google, Azure, and Oracle and S3, SQS, SNS, EC2, CloudFormation and RDS.
  • Knowledge of geospatial data formats, tools, and standards (e.g., OGC, GeoServer, PostGIS, ESRI).
  • Experience with IC enterprise environments and tools (e.g., Keycloak, Vault, CloudFormation)
  • Certifications such as AWS Certified Developer, CISSP, Security+, SAFe Agile or similar.

Who we are:
Reinventing Geospatial, Inc. (RGi) is a fast-paced small business that has the environment and culture of a start-up, with the stability and benefits of a well-established firm. We solve complex problems within geospatial software development and national defense to make an Immediate Impact for our nation's soldiers and analysts.
We pride ourselves on giving employees an exceptional life experience, where creativity thrives, and challenges are simply part of the fun. We provide truly excellent benefits, including:
• 100% paid employee healthcare & dental insurance
• Paid parental leave
• 401k with matching
• Escalating vacation time
• Referral bonuses
• Tuition reimbursement
• Professional development training
• Free beverages and snacks
• Weekly catered lunches and breakfast on Fridays
Grow to be our next leader:
At RGi, fostering a strong and organic corporate culture is paramount and serves as a compass on the decisions we make and how we operate the company. We believe our culture of camaraderie, innovation, and collaboration reflects the caliber of our employees and their dedication to the mission of providing quality software to our customers. As such, we want our employees to feel empowered to seek growth and leadership opportunities within the company and position us to maintain our culture as we grow. RGi provides opportunities, resources, training, and mentorship to all our employees to let them take control of their careers and become a leader or a crucial member of our company. If this is what you are looking for in a company, then you are what we are looking for in an employee.
Reinventing Geospatial, Inc. is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, religion, sex, national origin, age, veteran status, disability, or any other protected class. U.S. Citizenship is required for all positions.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

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