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Protein Purification Process Development Jobs in California

Revvity

Intern - Cell Analysis

San Diego, CA

$16 - $21.25/hr

... development, and career growth within a leading biotechnology company. The individual will perform laboratory-based protein processing, including cell lysis, refolding, and purification using various ...

3 Key Consulting

The ideal candidate should have a strong background in biochemistry, protein purification ... Interview Process: Initial phone screen - HM. Follow up phone interview - HM + 1 other We invite ...

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All JobsProtein Purification Process Development JobsProtein Purification Process Development Jobs in California

Protein Purification Process Development information

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$18

$33

$48

How much do protein purification process development jobs pay per hour?

As of Jun 14, 2026, the average hourly pay for protein purification process development in California is $33.24, according to ZipRecruiter salary data. Most workers in this role earn between $27.26 and $40.82 per hour, depending on experience, location, and employer.

What is the difference between Protein Purification Process Development vs Protein Purification Technician?

AspectProtein Purification Process DevelopmentProtein Purification Technician
CredentialsBachelor's or higher in Biochemistry, Molecular Biology, or related fieldsAssociate's or Bachelor's in Life Sciences or related areas
Work EnvironmentResearch labs, development facilities, collaborative teamsManufacturing or production labs, hands-on processing
ResponsibilitiesDesigning protocols, optimizing purification methods, process scale-upExecuting purification procedures, operating equipment, maintaining documentation

Protein Purification Process Development professionals focus on designing and optimizing purification methods, often working in research and development settings. In contrast, Protein Purification Technicians perform routine purification tasks, operating equipment in manufacturing environments. Both roles require knowledge of protein chemistry but differ in scope, responsibilities, and work environment.

What is protein purification process development?

Protein purification process development is the design, optimization, and scaling up of methods to isolate and purify proteins from complex biological mixtures. This field involves selecting appropriate techniques like chromatography, filtration, and centrifugation to obtain a protein of interest with high purity and yield. Professionals in this area work on developing efficient, reproducible, and cost-effective processes that can be transferred from laboratory scale to industrial manufacturing. They also ensure the process meets regulatory standards for use in pharmaceuticals, research, or industrial applications.

What are the key skills and qualifications needed to thrive in Protein Purification Process Development, and why are they important?

To excel in Protein Purification Process Development, a strong background in biochemistry, molecular biology, or chemical engineering—often with a relevant degree or advanced degree—is essential. Familiarity with chromatographic techniques (such as HPLC, FPLC), analytical instruments, and regulatory documentation systems like GMP are typically required. Strong problem-solving, attention to detail, and effective collaboration skills help professionals optimize processes and troubleshoot issues. Mastery of these skills ensures the efficient development of scalable purification methods, high product yield, and compliance with quality standards.

What are some common challenges faced during protein purification process development, and how are they typically addressed?

Protein purification process development often involves overcoming challenges such as low protein yield, maintaining protein stability, and removing impurities efficiently. To address these, scientists frequently optimize buffer conditions, select appropriate chromatography methods, and test various purification strategies in small-scale experiments before scaling up. Cross-functional collaboration with analytical and downstream processing teams is essential to troubleshoot issues and ensure process robustness. Continuous learning and adaptability are key, as each protein can present unique purification challenges.
What are popular job titles related to Protein Purification Process Development jobs in California? For Protein Purification Process Development jobs in California, the most frequently searched job titles are:
What job categories do people searching Protein Purification Process Development jobs in California look for? The top searched job categories for Protein Purification Process Development jobs in California are:
Protein Purification Process Development jobs near you
Infographic showing various Protein Purification Process Development job openings in California as of June 2026, with employment types broken down into 1% As Needed, 80% Full Time, 16% Part Time, and 3% Contract. Highlights an 93% Physical, 3% Hybrid, and 4% Remote job distribution, with an average salary of $69,143 per year, or $33.2 per hour.
Research Associate I (Temporary) - Protein Biochemistry

Research Associate I (Temporary) - Protein Biochemistry

Tentarix Biotherapeutics, Inc.

San Diego, CA

$28 - $34/hr

Other

Posted 6 days ago

Job description

About Us:

Tentarix Biotherapeutics is a biotechnology company with a revolutionary platform for the discovery of next generation, multispecific biologic drugs, with the potential to make a significant difference in the lives of patients suffering with diseases, such as cancer and autoimmunity.

We are led by a seasoned executive team with proven expertise in the field of multispecific drug discovery, drug development, and company-building. We are supported by top tier healthcare investors and have several ongoing partnered programs with Gilead and AbbVie.

We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape.

The Tentarix culture is founded on integrity, accountability, teamwork, and respect. Our team members are creative, hands-on, self-directed, and determined. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our team.

Role:

We are seeking a Full-Time Temporary Research Associate I (6-month role) to support our Protein Biochemistry, Process Development and Purification team. This Research Associate I will be working in a highly cross-functional team. The role will be assisting laboratory staff with protein purification and characterization.  

Key Responsibilities:

  • Assist the team with routine purification and characterization, including but not limited to affinity, IEX and MMC chromatography
  • Assist the team with characterization of molecules via CE-SDS, SDS-PAGE, HPLC/UPLC, and DSF
  • Keep accurate lab records and follow standard lab protocols
  • Maintain laboratory stocks and consumables
  • Maintain laboratory cleanliness and good manufacturing standards

Qualifications:B.A/B.S. in Biology, Biochemistry, Molecular Biology, or a related field. Experience is preferred but not required

  • Interest in liquid chromatography, protein sciences or drug discovery
  • Eagerness to learn new skills, concepts and techniques
  • Strong organizational skills and attention to detail
  • Demonstrate strong initiative and ability to work independently
  • Excellent verbal and written communication skills
  • Ability to work in a fast-paced, collaborative environment

The range for this hourly temporary role is $28-34 per hour, depending on experience. This role will require 40 hours per week and is located in upper La Jolla.

Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. All applicants must be eligible to work in the United States.

Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. We are an E-Verify employer.

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