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Protein Expression Jobs (NOW HIRING)

Medra

Research Associate - Protein

San Francisco, CA · On-site

Execute protein expression experiments across multiple host systems (e.g., mammalian, E. coli, cell-free) at various scales, from small-scale screens to larger production runs * Run protein ...

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Protein Expression information

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$16

$35

$62

How much do protein expression jobs pay per hour?

As of Jul 21, 2026, the average hourly pay for protein expression in the United States is $35.05, according to ZipRecruiter salary data. Most workers in this role earn between $25.48 and $41.59 per hour, depending on experience, location, and employer.

What is protein expression?

Protein expression refers to the process by which proteins are synthesized, modified, and regulated in living organisms. In biotechnology and research, protein expression often means the artificial production of specific proteins in host cells, such as bacteria, yeast, or mammalian cells, using recombinant DNA technology. This process is crucial for studying protein function, developing pharmaceuticals, and producing enzymes or other protein-based products. The choice of expression system depends on factors like the protein's complexity and the need for post-translational modifications.

What are the key skills and qualifications needed to thrive as a Protein Expression Scientist, and why are they important?

To thrive as a Protein Expression Scientist, you need a strong background in molecular biology, biochemistry, and cell culture, often supported by a relevant degree (such as in biology, biochemistry, or biotechnology). Familiarity with expression systems (E. coli, yeast, insect, or mammalian cells), chromatography, and analytical tools like SDS-PAGE and Western blot is essential, and experience with laboratory information management systems (LIMS) or certifications in laboratory safety can be advantageous. Strong problem-solving abilities, attention to detail, and effective communication skills are valuable soft skills in this field. These competencies ensure accurate protein production, efficient troubleshooting, and clear collaboration, which are crucial for successful research and development in biotechnology and pharmaceutical settings.

What are some common challenges faced in a Protein Expression role, and how can they be addressed?

Professionals in Protein Expression often encounter challenges such as optimizing expression levels, ensuring protein solubility, and maintaining protein functionality. Troubleshooting requires a strong understanding of expression systems (bacterial, yeast, insect, or mammalian), vector design, and purification methods. Collaboration with molecular biologists and biochemists is essential to troubleshoot issues and adapt protocols, while ongoing learning about new expression technologies can help address complex problems and enhance productivity.

What is the difference between Protein Expression vs Protein Purification?

AspectProtein ExpressionProtein Purification
Primary FocusProducing proteins within cells or systemsIsolating and cleaning proteins from mixtures
Work EnvironmentLaboratories involving genetic engineering and cell cultureLaboratories focused on protein isolation and analysis
Required SkillsMolecular biology, cloning, cell cultureChromatography, protein analysis, assay techniques
Industry UsageBiotech, pharmaceuticals, researchBiotech, pharmaceuticals, research

Protein Expression involves creating proteins within cells using genetic techniques, while Protein Purification focuses on isolating and refining those proteins for study or application. Both roles are essential in biotech and research settings, often overlapping but distinct in their primary objectives.

More about Protein Expression jobs
What cities are hiring for Protein Expression jobs? Cities with the most Protein Expression job openings:
What states have the most Protein Expression jobs? States with the most job openings for Protein Expression jobs include:
What job categories do people searching Protein Expression jobs look for? The top searched job categories for Protein Expression jobs are:
Protein Expression jobs near you
Infographic showing various Protein Expression job openings in the United States as of July 2026, with employment types broken down into 1% As Needed, 72% Full Time, 26% Part Time, and 1% Contract. Highlights an 96% Physical, 1% Hybrid, and 3% Remote job distribution, with an average salary of $72,895 per year, or $35 per hour.
Research Associate - Protein Production

Research Associate - Protein Production

Helix Biostructures

Indianapolis, IN • On-site

$14.25 - $18.25/hr

Full-time

Medical, Dental, Vision, Retirement

Posted 14 days ago

Job description

Research Associate - Protein Production
Helix BioStructures, LLC (HBS) is a contract research organization (CRO) based in Indianapolis, Indiana, providing early drug discovery services to the biopharmaceutical industry. HBS maintains a full suite of services that encompass chemical & structural analysis, protein production, computational modeling, and design. HBS's core and most popular services are structural biology imaging techniques: X-ray Crystallography and Cryo-EM. HBS was founded in 2018 and has grown considerably. We are looking to add a Research Associate to independently execute protein expression, purification, and characterization workflows for client projects in our Indianapolis-based lab.
Main Responsibilities
This research associate will independently execute protein expression, purification, and biophysical characterization workflows in support of client projects, including preparing reagents, buffers, and media as needed for assigned experiments. The associate will collect, analyze, and interpret experimental data, troubleshoot routine technical issues, and communicate results to project managers. The associate will also perform routine maintenance and calibration of laboratory equipment, maintain detailed and accurate documentation of experimental procedures and results, and contribute to a clean, organized, and safe laboratory environment.
Highly desirable hands-on experiences include:
(a) Hands-on experience independently running protein expression and/or purification (academic or industrial), such as FPLC-based chromatography.
(b) Working knowledge of core wet-lab fundamentals, including buffer/media preparation, pipetting and aseptic technique, SDS-PAGE, and basic chromatography.
In this role, the research associate will independently manage protein production workstreams for client projects spanning structure-based drug discovery, antibody discovery, and protein engineering. Accordingly, a solid foundation in laboratory fundamentals, strong attention to detail, and the ability to troubleshoot independently are essential. The successful candidate will take ownership of assigned projects, manage multiple projects in parallel, and collaborate with senior scientists and other team members in a fast-paced, collaborative CRO environment.
Additional Responsibilities
  • Independently plan and execute protein expression and purification runs to meet client project timelines and specifications.
  • Prepare laboratory reagents, buffers, and media as needed to support assigned experiments, and perform routine maintenance and calibration of laboratory equipment.
  • Prepare detailed and accurate documentation of laboratory procedures, observations, and results.
  • Provide general laboratory support, including inventory management and ordering supplies.
  • Participate in team meetings and contribute to discussions on project progress and improvements.

Required Qualifications
  • Bachelor's degree in biochemistry, molecular biology, biology, or a related field, with 1-5 years of hands-on laboratory experience.
  • Hands-on experience independently performing recombinant protein expression and/or purification (academic or industrial) is required.
  • Familiarity with fundamental wet-lab techniques such as pipetting, solution and buffer preparation, SDS-PAGE, and basic chromatography.
  • Strong attention to detail with accurate and organized record-keeping.
  • Ability to follow established protocols and adhere to laboratory safety procedures.
  • Good written and oral communication skills and a willingness to learn new techniques.

Additional qualifications
  • Hands-on experience with recombinant protein expression and/or purification in bacterial, insect, or mammalian systems.
  • Exposure to biophysical or analytical techniques (e.g., size-exclusion chromatography, SDS-PAGE, TSA, UV/Vis spectroscopy).
  • Experience with laboratory inventory, LIMS, or electronic lab notebook (ELN) systems.
  • Exposure to structural biology (X-ray crystallography or Cryo-EM) is a plus but not required.
  • Excellent organizational and time-management skills.
  • Excellent communication and interpersonal skills.
  • Eagerness to take on new challenges and learn on the job.

Location
This position is based in Indianapolis, Indiana, and does NOT offer a hybrid option. Interaction with external service vendors is also expected. Candidates must be authorized to work in the United States; Helix BioStructures does NOT provide visa sponsorship for this position.
Physical Requirements
Able to lift 30 lb objects with dimensions 30 inches in height and 18 inches in width.
Able to visualize microscopic objects under microscopes.
Non-standard work schedule, travel, and lab safety
Able to adhere to safe work practices and perform lab work with appropriate personal protective equipment, such as but not limited to safety goggles, facial mask, gloves, lab coat/ protective gowning, and closed-toe shoes. Able to work at flexible hours occasionally when performing time-sensitive experiments.
Other job details
  • Eligible for Relocation Package
  • Competitive Salary + annual bonus
  • Retirement (matching 401K)
  • Health/Dental/Vision Insurance
  • Company Apple Computer

Helix BioStructures, LLC is an equal opportunity employer, and we embrace the increasingly diverse world around us. Helix BioStructures, LLC prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status.

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