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Protein Expression Jobs (NOW HIRING)

TechData Service Company LLC

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Formulation Scientist

Alameda, CA · On-site

$40 - $60/hr

W2 Position Summary The Lead Discovery and Structural Biology Department within client is seeking a highly qualified Protein Expression & Purification Scientist (Contractor) with demonstrated ...

Lila Sciences

Co-op, Protein Sciences

Cambridge, MA

The focus of this role will be cell culture and cell lysis to generate materials for protein expression. You will continue maintenance and optimization of the cell free platform here at Lila. What ...

Arcadia Science

Protein Designer

Emeryville, CA · On-site

$130K - $180K/yr

Experience with protein biology, biochemistry, or cell biology to inform protein expression and purification, assay development, experimental design, etc. * Experience in at least one programming ...

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Protein Expression information

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$16

$35

$62

How much do protein expression jobs pay per hour?

As of Jun 29, 2026, the average hourly pay for protein expression in the United States is $35.05, according to ZipRecruiter salary data. Most workers in this role earn between $25.48 and $41.59 per hour, depending on experience, location, and employer.

What is protein expression?

Protein expression refers to the process by which proteins are synthesized, modified, and regulated in living organisms. In biotechnology and research, protein expression often means the artificial production of specific proteins in host cells, such as bacteria, yeast, or mammalian cells, using recombinant DNA technology. This process is crucial for studying protein function, developing pharmaceuticals, and producing enzymes or other protein-based products. The choice of expression system depends on factors like the protein's complexity and the need for post-translational modifications.

What are the key skills and qualifications needed to thrive as a Protein Expression Scientist, and why are they important?

To thrive as a Protein Expression Scientist, you need a strong background in molecular biology, biochemistry, and cell culture, often supported by a relevant degree (such as in biology, biochemistry, or biotechnology). Familiarity with expression systems (E. coli, yeast, insect, or mammalian cells), chromatography, and analytical tools like SDS-PAGE and Western blot is essential, and experience with laboratory information management systems (LIMS) or certifications in laboratory safety can be advantageous. Strong problem-solving abilities, attention to detail, and effective communication skills are valuable soft skills in this field. These competencies ensure accurate protein production, efficient troubleshooting, and clear collaboration, which are crucial for successful research and development in biotechnology and pharmaceutical settings.

What are some common challenges faced in a Protein Expression role, and how can they be addressed?

Professionals in Protein Expression often encounter challenges such as optimizing expression levels, ensuring protein solubility, and maintaining protein functionality. Troubleshooting requires a strong understanding of expression systems (bacterial, yeast, insect, or mammalian), vector design, and purification methods. Collaboration with molecular biologists and biochemists is essential to troubleshoot issues and adapt protocols, while ongoing learning about new expression technologies can help address complex problems and enhance productivity.

What is the difference between Protein Expression vs Protein Purification?

AspectProtein ExpressionProtein Purification
Primary FocusProducing proteins within cells or systemsIsolating and cleaning proteins from mixtures
Work EnvironmentLaboratories involving genetic engineering and cell cultureLaboratories focused on protein isolation and analysis
Required SkillsMolecular biology, cloning, cell cultureChromatography, protein analysis, assay techniques
Industry UsageBiotech, pharmaceuticals, researchBiotech, pharmaceuticals, research

Protein Expression involves creating proteins within cells using genetic techniques, while Protein Purification focuses on isolating and refining those proteins for study or application. Both roles are essential in biotech and research settings, often overlapping but distinct in their primary objectives.

More about Protein Expression jobs
What cities are hiring for Protein Expression jobs? Cities with the most Protein Expression job openings:
What states have the most Protein Expression jobs? States with the most job openings for Protein Expression jobs include:
What job categories do people searching Protein Expression jobs look for? The top searched job categories for Protein Expression jobs are:
Protein Expression jobs near you
Infographic showing various Protein Expression job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 90% Physical, 1% Hybrid, and 9% Remote job distribution, with an average salary of $72,895 per year, or $35 per hour.

Scientist - Protein Engineering

Merge Labs

San Francisco, CA • On-site

$120K - $215K/yr

Full-time

Posted 7 days ago

Job description

Merge Labs is a frontier research lab with the mission of bridging biological and artificial intelligence to maximize human ability, agency and experience. We're pursuing this goal by developingfundamentally new approaches to brain-computer interfaces that interact with the brain at high bandwidth, integrate with advanced AI, and are ultimately safe and accessible for anyone to use.
About the team:
Our Bio team designs, builds, and characterizes the biotechnologies that form the foundation of next-generation brain-computer interfaces. We combine molecular engineering, synthetic biology, neuroscience, and advanced physical methods such as ultrasound to establish less invasive, high-bandwidth connections with neurons. The Bio team develops our core molecular technologies, validates their performance in vitro and in vivo, and demonstrates their advanced capabilities in animal models. We build custom experimental setups and pipelines and collaborate closely with engineers and data scientists. We work across disciplines to come up with creative ideas and solve some of the most challenging problems in biotechnology.
About the role
As a Protein Engineer in a BCI company, you will design, build, and optimize the key biomolecules that translate between the languages of cells and machines - turning neuronal activity at the molecular scale into interpretable signals and enabling precise modulation.
You'll work with unconventional proteins - from atypical biosensors and membrane proteins to complex, multi-component assemblies - and use your biophysical insights, high-throughput experimental methods, and close collaboration with our computational team to push the boundaries of what these molecules can do. Your work will set the molecular foundation for next-generation brain-computer interfaces.
In this role, you will:
  • Design and implement diverse protein engineering strategies - from rational design and computational modeling to directed evolution and combinatorial library - to build dynamic molecular systems with desirable properties.
  • Build and characterize protein variants at high throughput to test and iterate hypotheses rapidly and rigorously: implement and optimize scalable workflows from library generation, expression in various in vitro systems, to standard and custom assays.
  • Collaborate with our computational team to establish models linking sequences and structures to function, guide the generation of future constructs, and augment our intuition.
  • Explore the mechanisms behind complex biomolecules and translate that understanding into creative, out-of-the-box designswith the support of our biochemists, structural biologists, and computational teams.
  • Develop novel screening and validation methods to further accelerate the entire design-build-iterate loop and ensure a smooth transition toward in vivo applications.

You might thrive in this role if you:
  • Have a PhD in Bioengineering, Biophysics, Biochemistry, or a related field, or have equivalent experience leading research projects end-to-end.
  • Are proficient in library construction, protein expression in mammalian cells, and standard characterization.
  • Are comfortable using computational approaches for protein engineering and understand the fundamental principles involved.
  • Think mechanistically: you are motivated by understanding how things work, not just that they work.
  • Enjoy working with dynamic, multi-state proteins and/or complex protein assemblies.
  • Feel joy in collaboration and communicate naturally with experts across disciplines.
  • Are energized by 0->1 innovations and always on the lookout for creative ways to do better.
  • Want to be part of a fast-paced team working on frontier scientific and technical problems.

Nice to have
  • Experience with engineering multi-state proteins, membrane proteins, and multi-component protein assemblies.
  • Experience with protein expression in primary neurons, brain organoids, or brain tissues.
  • Experience with large-scale screening.
  • Experience with creative assay development.
  • Familiarity with machine learning or data-driven design approaches.

If you're excited about this role but don't meet every qualification, please apply. As we build, we're hiring for complementary strengths to form a high-impact team.
For more information about hiring at Merge, please visit our Hiring FAQ
Merge Labs does not discriminate on the basis of race, color, religion, national origin, age, sex, sexual orientation, gender, gender identity, gender expression, marital status, physical or mental disability, medical condition, genetic information, family status, ancestry, citizenship, U.S. military (state and federal) and veteran status, or any other legally protected status. It is our intention that all applicants be given equal opportunity and that selection decisions are based on job related factors. We are an equal opportunity employer.
Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.
We are committed to providing reasonable accommodations to applicants with disabilities, and requests can be made by emailing accommodations@merge.io.

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