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Protein Expression Jobs (NOW HIRING)

Execute protein expression experiments across multiple host systems (e.g., mammalian, E. coli, cell-free) at various scales, from small-scale screens to larger production runs * Run protein ...

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Protein Expression information

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$16

$35

$62

How much do protein expression jobs pay per hour?

As of Aug 30, 2026, the average hourly pay for protein expression in the United States is $35.05, according to ZipRecruiter salary data. Most workers in this role earn between $25.48 and $41.59 per hour, depending on experience, location, and employer.

What is protein expression?

Protein expression refers to the process by which proteins are synthesized, modified, and regulated in living organisms. In biotechnology and research, protein expression often means the artificial production of specific proteins in host cells, such as bacteria, yeast, or mammalian cells, using recombinant DNA technology. This process is crucial for studying protein function, developing pharmaceuticals, and producing enzymes or other protein-based products. The choice of expression system depends on factors like the protein's complexity and the need for post-translational modifications.

What are the key skills and qualifications needed to thrive as a protein expression scientist, and why are they important?

To thrive as a Protein Expression Scientist, you need a strong background in molecular biology, biochemistry, and cell culture, often supported by a relevant degree (such as in biology, biochemistry, or biotechnology). Familiarity with expression systems (E. coli, yeast, insect, or mammalian cells), chromatography, and analytical tools like SDS-PAGE and Western blot is essential, and experience with laboratory information management systems (LIMS) or certifications in laboratory safety can be advantageous. Strong problem-solving abilities, attention to detail, and effective communication skills are valuable soft skills in this field. These competencies ensure accurate protein production, efficient troubleshooting, and clear collaboration, which are crucial for successful research and development in biotechnology and pharmaceutical settings.

What are some common challenges faced in a protein expression role, and how can they be addressed?

Professionals in Protein Expression often encounter challenges such as optimizing expression levels, ensuring protein solubility, and maintaining protein functionality. Troubleshooting requires a strong understanding of expression systems (bacterial, yeast, insect, or mammalian), vector design, and purification methods. Collaboration with molecular biologists and biochemists is essential to troubleshoot issues and adapt protocols, while ongoing learning about new expression technologies can help address complex problems and enhance productivity.

What is the difference between Protein Expression vs Protein Purification?

AspectProtein ExpressionProtein Purification
Primary FocusProducing proteins within cells or systemsIsolating and cleaning proteins from mixtures
Work EnvironmentLaboratories involving genetic engineering and cell cultureLaboratories focused on protein isolation and analysis
Required SkillsMolecular biology, cloning, cell cultureChromatography, protein analysis, assay techniques
Industry UsageBiotech, pharmaceuticals, researchBiotech, pharmaceuticals, research

Protein Expression involves creating proteins within cells using genetic techniques, while Protein Purification focuses on isolating and refining those proteins for study or application. Both roles are essential in biotech and research settings, often overlapping but distinct in their primary objectives.

More about Protein Expression jobs

What cities are hiring for Protein Expression jobs?

Cities with the most Protein Expression job openings:

What states have the most Protein Expression jobs?

States with the most job openings for Protein Expression jobs include:

Infographic showing various Protein Expression job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 70% Full Time, 27% Part Time, and 2% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $72,895 per year, or $35 per hour.

Senior Scientist - Protein Expression Sciences

Tarrytown, NY • On-site


Regeneron Pharmaceuticals
Biotechnology Research and Development • 5 - 10K employees

8.5

Company rating: 8.5 out of 10

Based on 44 frontline employees who took The Breakroom Quiz

19th of 86 rated pharmaceutical

Good employer

Recommended by parents

Respectful managers


$109K - $179K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 10 days ago


Job description

Build our future together:

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated Senior Scientist to join our Protein Expression Sciences Department. In this role, you will create antibody production cell lines using state-of-the-art mammalian expression technologies and develop new technologies to further advance our expression platform, while collaborating with cross-functional scientific teams.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & where:
  • Location: Tarrytown, NY
  • Work model: On-site
Discover your role:
  • Apply innovative mammalian expression technologies to generate regulatory-compliant stable cell lines
  • Perform aseptic cell culture, handling, and transfection of cell lines
  • Conduct flow cytometry assays and operate liquid handler platforms (Hamilton) to analyze stable cell lines
  • Perform molecular biology and protein biochemistry techniques, including PCR, RT-PCR, plasmid sub-cloning, isolation of genomic DNA and RNA from CHO cells, SDS-PAGE, and western blotting
  • Independently design, conduct, and analyze multicolor flow cytometry experiments
  • Analyze and present data at smaller team and broader department meetings
  • Maintain complete, accurate, and timely records of experiments and data analysis
This role requires:
  • PhD with 0-3 years of postdoctoral experience, or BS/MS with 4-8 years of experience, in Immunology, Cell Biology, or Molecular Biology
  • Hands-on technical experience in cell culture, flow cytometry, and antibody staining
  • Experience with molecular biology techniques such as PCR and cloning
  • Passion for innovation and a desire to lead new scientific directions
  • Working independently, demonstrating strong problem-solving skills and the ability to manage multiple tasks efficiently without direct supervision
  • Strong desire to develop your skills and work with a cross-functional team and the ability to thrive in a collaborative, fast-paced environment
  • Experience with gene editing, lentivirus infections, CRISPR library workflows, and NGS is a plus

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.


Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed onsite. Please speak with your recruiter and hiring manager for more information about onsite expectations for your role and location.


As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.


For jobs in Canada: this posting is for an existing position.


Salary Range (annually)

$109,900.00 - $179,300.00


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