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Program Operations Director Jobs in Quincy, MA (NOW HIRING)

Lumanity

Director, Sales Operations

Boston, MA

... a commercially minded Director, Sales Operations (internally known as ("FP&A Commercial ... Support the design, tracking, and reporting of sales incentive programs and performance against ...

Prime Outlets

Assistant Director, Operations

Boston, MA

$78K - $126K/yr

Partners with the Operations Director to manage Property Operating expenses within or below budget ... This may include administration of and training for programs such as OSHA, ADA, EPA and other ...

inno

Clinical Operations Specialist

Middleton, MA

Provides administrative support to Clinical Director, Operations Director, and other employees as needed. * Reads and adheres to and participates in the Branch's mandatory HIPAA/Privacy Program and ...

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All JobsProgram Operations JobsProgram Operations Director JobsProgram Operations Director Jobs in Quincy, MA

Program Operations Director information

See Quincy, MA salary details

$35.8K

$113.2K

$188.7K

How much do program operations director jobs pay per year?

As of Aug 12, 2026, the average yearly pay for program operations director in Quincy, MA is $113,221.00, according to ZipRecruiter salary data. Most workers in this role earn between $79,400.00 and $142,500.00 per year, depending on experience, location, and employer.

What does a Program Operations Director do?

A Program Operations Director oversees the daily operations and strategic management of programs within an organization. They ensure that programs are executed efficiently, meet organizational goals, and comply with relevant regulations and standards. Their responsibilities often include coordinating between departments, managing budgets, supervising staff, and evaluating program effectiveness. This role requires strong leadership, problem-solving, and communication skills to keep programs running smoothly and achieving desired outcomes.

What are the key skills and qualifications needed to thrive as a Program Operations Director, and why are they important?

To thrive as a Program Operations Director, you need strong leadership abilities, program management experience, and a background in business administration or a related field. Proficiency with project management software, data analysis tools, and relevant certifications like PMP are often important. Excellent communication, problem-solving, and organizational skills help you motivate teams and navigate complex operational challenges. These skills and qualities are critical for ensuring that programs run efficiently, achieve goals, and align with organizational strategy.

What are some common challenges a Program Operations Director faces in managing cross-functional teams?

A Program Operations Director often encounters challenges related to aligning priorities and communication across diverse departments such as finance, HR, and project management. Coordinating these groups requires strong organizational and interpersonal skills to ensure everyone is working towards shared objectives and deadlines. Additionally, adapting to shifting project scopes and managing resource constraints are frequent hurdles, making flexibility and problem-solving essential traits for success in this role.

What is the difference between Program Operations Director vs Program Manager?

AspectProgram Operations DirectorProgram Manager
ResponsibilitiesOversees multiple programs, strategic planning, and high-level operationsManages individual programs, project execution, and team coordination
Required CredentialsTypically requires a bachelor’s degree, often a master’s, with experience in operations or managementUsually requires a bachelor’s degree, with project management experience
Work EnvironmentExecutive-level setting, strategic planning, cross-department collaborationProject teams, day-to-day program execution, stakeholder communication
Industry UsageCommon in nonprofit, government, and corporate sectors for overseeing multiple initiativesUsed across industries for managing specific projects within programs

The Program Operations Director focuses on strategic oversight and managing multiple programs at a high level, while the Program Manager handles the execution of individual programs. Both roles require relevant experience and credentials, but the Director operates at a broader, more strategic level.

What job categories do people searching Program Operations Director jobs in Quincy, MA look for? The top searched job categories for Program Operations Director jobs in Quincy, MA are:
What cities near Quincy, MA are hiring for Program Operations Director jobs? Cities near Quincy, MA with the most Program Operations Director job openings:
Program Operations Director jobs near you
Infographic showing various Program Operations Director job openings in Quincy, MA as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 1% Temporary, and 4% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $113,221 per year, or $54.4 per hour.

Sr. Director, Program Management & Business Operations

Flagship Pioneering, Inc.

Cambridge, MA • On-site

Full-time

Medical, Retirement

Re-posted 8 days ago

Job description

About Alltrna
Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company's initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.
Alltrna's lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics.
For more information, visit www.alltrna.com
Sr. Director Program Management & Business Operations
Position Summary:
Alltrna is seeking a talented and highly motivated Sr. Director Program Management and Business Operations, reporting to the President & CFO. The successful candidate is a proven leader with extensive experience in leading research and early drug development program teams from research through the clinic with a particular initial focus on IND enabling and early/mid-stage clinical development. The candidate will be a member of the Company's Leadership Team and will serve as Chief of Staff to the team to drive collaboration, cross-functional clarity, alignment and execution on key priorities and initiatives required to meet the goals of the organization.
Key Responsibilities:
Program Management:
  • Work closely with the Chief Medical Officer to lead the program team for the Company's lead program, AP003, and future programs instilling a culture of scientific rigor, open debate, collaborative teamwork, sense of urgency and accountability
  • Possess a comprehensive understanding of the drug discovery process to guide program teams to define the key scientific questions, program strategy and objectives, translating these into optimal deliverables, cross-functional plans, timelines and budgets
  • Identify bottlenecks, risks, issues and proactively develop appropriate mitigation proposals with input from team members
  • Ensure all key decisions are identified and properly assessed as to their impact and alternative scenarios developed and evaluated, where appropriate
  • Work closely with finance and functional teams to develop the operational plans to support program activities with realistic timelines, budget, and resource planning and monitor performance against plans
  • Interface with and drive collaboration between the various functional teams and with the Leadership Team on program-related matters.
  • Be the key accountable person for communicating matters related to the programs to management including strategy, work product, updates and issues; producing the one "source of truth" for program-related topics and timelines
  • Point person for alliance management and coordination, as needed
  • Lead and/or manage strategic or platform development projects as required and collaborate with Chief Scientific Officer and Research Leadership Team to coordinate relevant content for quarterly business review meetings

Operations:
  • Collaborate with Leadership Team in development of strategic plans, company goals, long-range planning assumptions, portfolio-level reports and analyses to support business processes and strategic discussions
  • Develop and deliver impactful presentations that effectively distill complex issues to the critical points and lead to increased understanding and optimized strategic planning & decision-making
  • Prepare strategic communications utilizing a clear understanding of the business strategy and issues; develop and maintain consistent, relevant content for use in executive-level communications and to further organizational and business goals
  • Lead the Scientific Communications process, working with the Scientific Communications Committee
  • Manage schedule, agenda, and content for Leadership Team, Board of Directors and Town Hall meetings
  • Proactively seek opportunities for organizational improvements (e.g. team structure, processes, communication, etc.)

Other:
  • Support CEO / LT with partnership discussions and negotiations, including background research, preparation of presentation materials, supporting diligence activities, participating in analysis of terms, etc.
  • Assist in mapping competitive landscape and proactively identify potential and emerging competitive threats and opportunities
  • Promote strategic discussions on external trends, competitor strategies, and potential disruptors, and translate these into strategic choices/ recommendations
  • Collect insights and intelligence from a variety of sources including literature searches, reviewing analyst research, KOL and patient group interactions, etc.

Key Competencies:
  • This is a highly visible leadership role that requires exceptional interpersonal and communication skills, creative thinking, and early drug development experience that allows one to recognize opportunities/challenges and modify strategy accordingly
  • The individual will need to have self-confidence and poise to manage complicated programs and projects with multiple stakeholders
  • The individual will need a sense of urgency and can-do attitude to develop therapies for patients with significant unmet medical needs

Minimum Qualifications:
  • BS/MS Degree in a scientific discipline, ideally life science or chemistry.
  • At least 15 years relevant experience in pharma or biotech drug discovery and development, as well as a comprehensive understanding of drug discovery (preclinical and clinical).
  • 10+ years of Program Management experience, preferably in early-stage drug discovery and development.
  • Experience in the development of advanced therapies to treat rare genetic disease is a plus
  • Demonstrated experience leading cross-functional teams; strong interpersonal and communication skills
  • Scientific curiosity and passion for discovering new, innovative medicines.
  • Openness to embrace new technologies and digital approaches in drug discovery
  • Proven track record in driving successful, collaborative drug discovery teams.

The salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.

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