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Principal Systems Design Engineer Jobs (NOW HIRING)

Myomo, Inc

Principal Systems Engineer

Burlington, MA · On-site

$165K - $185K/yr

The Principal Systems Engineer leads system-level design and integration activities for Myomo's medical device product line. This role defines product architecture, ensures alignment between ...

Socket.dev

Systems Design Engineer

Secaucus, NJ · On-site

$101K - $139K/yr

The Systems Design Engineering team fosters and encourages continuous technical innovation to showcase successes as well as facilitate continuous career development. THE PERSON: As a Systems Design ...

Boston Scientific Gruppe

$102K - $194K/yr

As a Principal Systems Design Engineer, you are responsible for system level design of complex implantable medical devices by developing system requirements from user needs and stakeholder inputs ...

CYNET SYSTEMS

Systems Design Engineer

Austin, TX · On-site

$62 - $65/hr

System Design. Qualification And Education: * Knowledge of Data Center systems that include CPU and GPUs. * Ability to function as both a technician and an engineer. Physical Requirements(Due to ...

Micron

Principal SSD Systems Design Engineer

Longmont, CO · On-site +1

$175K - $297K/yr

As a Principal SSD Systems Design Engineer within Micron's Solid State Drive (SSD) Product Development Team (PDT), you will serve as a technical leader and strategic influencer across global teams.

Emerson

Systems Design Architecture Engineer

Austin, TX

$99K - $135K/yr

The NI ADG (Aerospace, Defense, Government Business Unit) Customer Centric Solutions Team is seeking to hire an experienced Principal Systems Design Engineer to work on custom engineering ...

Sentrillion

Systems Design Engineer

Sierra Vista, AZ · On-site

$89K - $121K/yr

Sentrillion is seeking a Systems Design Engineer to support the design, deployment, installation, testing, verification, and administration of physical security systems, including surveillance ...

Sentrillion

Systems Design Engineer

Sierra Vista, AZ · On-site

$80K - $90K/yr

Sentrillion is seeking a Systems Design Engineer to support the design, deployment, installation, testing, verification, and administration of physical security systems, including surveillance ...

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How much do principal systems design engineer jobs pay per year?

As of Sep 13, 2026, the average yearly pay for principal systems design engineer in the United States is $149,214.00, according to ZipRecruiter salary data. Most workers in this role earn between $120,000.00 and $175,000.00 per year, depending on experience, location, and employer.

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Infographic showing various Principal Systems Design Engineer job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 85% Full Time, 9% Part Time, 4% Contract, and 1% Nights. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $149,214 per year, or $71.7 per hour.

Principal Systems Engineer

Burlington, MA • On-site

Myomo, Inc
Medical Equipment and Supplies Manufacturing • 1 - 10 employees
Learn more about Myomo, Incexternal

$165K - $185K/yr

Full-time

Posted 26 days ago

Key responsibilities

  • Lead design, development, and integration of medical devices and mechatronic subsystems to meet customer and business needs.

  • Define and maintain system architecture across hardware, software, and user interfaces in collaboration with engineering and product management.

  • Drive risk management and system-level verification and validation activities in accordance with medical device standards.

Job description

Principal Systems Engineer
Department: Engineering
Employment Type: Full Time
Location: Burlington, MA
Compensation: $165,000 - $185,000 / year
Description
Why should you join our success story?
Based on patented technology developed at MIT, Harvard Medical School and by the Company, Myomo develops and markets the MyoPro® product line of lightweight, non-invasive, powered arm braces (orthoses) to restore function in paralyzed or weakened arms and hands of individuals that have suffered a stroke, spinal cord, or nerve injury. (E.g. brachial plexus injury or other neuro-muscular disabilities.) It is the only device that, sensing a patient's own neurological signals through non-invasive wearable sensors, can restore the ability to use their arms and hands so that they can live independently, increase their quality of life, reduce cost of care, and return to work. Published clinical research shows a clinically significant instantaneous reduction in upper extremity impairment with the MyoPro. Our technology has been referred by leading-edge rehabilitation facilities including Mayo Clinic, Kennedy Krieger Institute, Cleveland Clinic, Loma Linda Medical Center, Massachusetts General Hospital, numerous VA Hospitals, and more. Myomo is headquartered in Burlington, Massachusetts, with sales and clinical professionals across the U.S.
What we're looking for:The Principal Systems Engineer leads system-level design and integration activities for Myomo's medical device product line. This role defines product architecture, ensures alignment between mechanical, electrical, and software components, and drives innovation aimed at enhancing performance, reliability, and safety. The Principal Systems Engineer provides technical leadership across cross-functional teams, ensuring that Myomo's products meet user needs, regulatory standards, and business goals.
How You'll Drive Impact:
  • Lead design, development, and integration of medical devices and mechatronic subsystems to meet customer and business needs.
  • Define and maintain system architecture across hardware, software, and user interfaces in collaboration with engineering and product management.
  • Translate customer and business requirements into functional, performance, and safety specifications.
  • Drive risk management and system-level verification and validation activities in accordance with medical device standards.
  • Develop prototypes, evaluating design concepts, driving innovative solutions in support of Myomo's intellectual property portfolio.
  • Ensure design intent and product reliability through cross-functional collaboration with Quality, Manufacturing, Clinical, and Customer support.
  • Apply requirements-driven design and systems engineering principles to manage trade-offs across cost, schedule, and performance.
  • Identify and mitigate technical and project risks, ensuring timely communication and resolution.
  • Promote continuous improvement in engineering processes, design practices, and documentation standards.
  • Mentor engineers across disciplines and fostering a collaborative, innovative engineering culture.

What You'll Bring:
  • Bachelor's or Master's degree in Biomedical, Mechanical, Electrical, or Systems Engineering.
  • 10-15 years of product development experience, including 5+ years in the medical device industry.
  • Proven track record of leading system design and integration for complex electromechanical products.
  • Prior experience defining architecture, requirements, and risk management in compliance with standards such as ISO 13485 and ISO 14971.
  • Strong background in innovation and intellectual property development (patent authorship preferred).
  • Knowledge of rapid-prototyping and manufacturing processes including 3D printing, CNC machining, and injection molding.
  • Familiarity with related engineering domains, including embedded software and electronics.
  • Demonstrated ability to manage multiple projects, prioritize effectively, and work independently with minimal supervision.
  • Excellent communication, collaboration, and problem-solving skills.
  • Attention to detail and strong organizational skills.

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