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Principal Statistician Jobs (NOW HIRING)

Jazz Pharmaceutical

Sr Principal Statistician

Palo Alto, CA · On-site +1

$102K - $125K/yr

The Senior Principal Statistician, Biostatistics will be a lead statistician on individual studies, across related studies, and for integrated summaries and will design and report Phase I to IV ...

PSI CRO

Principal Statistician

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

PSI CRO

Principal Statistician

Durham, NC

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

PSI CRO

Principal Statistician

Durham, NC

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

UCB

Principal Statistician, Raleigh, NC

Raleigh, NC · On-site

Make your mark for patients We are looking for a Principal Statistician who is collaborative, influential, and innovation-minded to join us in our Biometrics and Data Science team, based in our ...

PSI CRO

Principal Statistician

Durham, NC

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

PSI CRO

Principal Statistician

Durham, NC · On-site +1

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

Genentech

Senior Principal Statistician

Boston, MA

$94K - $116K/yr

Senior Principal Statistician A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations ...

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How much do principal statistician jobs pay per year?

As of Jun 9, 2026, the average yearly pay for principal statistician in the United States is $109,393.00, according to ZipRecruiter salary data. Most workers in this role earn between $85,000.00 and $125,000.00 per year, depending on experience, location, and employer.

What are Principal Statisticians?

Principal Statisticians are highly experienced professionals who lead statistical projects and teams, often within industries such as pharmaceuticals, healthcare, or market research. They are responsible for designing complex studies, analyzing large datasets, and ensuring the validity and accuracy of statistical results. In addition to technical expertise, Principal Statisticians provide guidance to junior staff, collaborate with cross-functional teams, and contribute to strategic decision-making. Their work is crucial in interpreting data to inform business or research outcomes.

What are the key skills and qualifications needed to thrive as a Principal Statistician, and why are they important?

To thrive as a Principal Statistician, you need advanced expertise in statistics, data analysis, and experimental design, usually backed by a master's or doctoral degree in statistics or a related field. Proficiency with statistical software such as SAS, R, and Python, as well as experience with data management systems, is essential. Strong leadership, problem-solving abilities, and effective communication skills help you collaborate with cross-functional teams and convey complex findings. These skills ensure robust study design, reliable data interpretation, and informed decision-making in research or business environments.

How does a Principal Statistician typically collaborate with cross-functional teams in a clinical research setting?

A Principal Statistician frequently works alongside clinical researchers, data managers, regulatory affairs, and medical writers to ensure statistical integrity throughout a study. They play a key role in designing protocols, defining endpoints, reviewing data quality, and interpreting results for regulatory submissions. These collaborations often involve leading statistical strategy meetings, providing guidance on data analysis plans, and ensuring compliance with industry standards. Clear communication and leadership are essential, as Principal Statisticians bridge technical statistical work with broader clinical objectives.
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Who are the top companies hiring for Principal Statistician jobs? The top employers for Principal Statistician jobs are:
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Principal Statistician jobs near you
Infographic showing various Principal Statistician job openings in the United States as of June 2026, with employment types broken down into 92% Full Time, 7% Part Time, and 1% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $109,393 per year, or $52.6 per hour.

Principal Statistician, Biostatistics

Jazz Pharmaceutical

Palo Alto, CA • On-site, Remote

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 28 days ago

Job description

If you are a current Jazz employee please apply via the Internal Career site
Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases - often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information.
Job Description
Brief Description:
The Principal Statistician, Biostatistics will be a lead statistician supporting the design and reporting of Phase I to IV clinical studies and support regulatory filings under the supervision of a more senior statistician. This role is responsible for the statistical aspects of study design, study analysis and validation, and study documentation. The Principal Statistician will provide timely and scientifically sound statistical expertise to clinical trials and develop and execute statistical strategy, design, and analyses for clinical trials. This position will work collaboratively with clinical development, pharmacology, pharmacovigilance, clinical drug supply, project management, regulatory affairs, medical writing, clinical data management, and clinical operations. The Principal Statistician will oversee work done by statistics and programming external vendors
Essential Functions
  • Participate in department and cross-functional meetings to optimize clinical study designs, endpoints, and analysis strategies.
  • Work collaboratively with members of study teams to meet study and recurring report timelines.
  • Support the development and implementation of study protocols.
  • Review and provide input to study-specific data capture systems and participate in their validation.
  • Develop statistical programs as necessary to simulate clinical trial design operating characteristics, perform analysis, prepare data displays, verify data accuracy and validity of analyses performed by statistical programming.
  • Write statistical analysis plans, perform data analysis and validation, and interpret analyses.
  • Support project lead statistician.
  • Prepare for and attend meetings with regulatory agencies.
  • Respond to statistical questions from regulatory agencies.
  • Work closely with statistical programming colleagues.
  • Monitor CRO guidelines and standards to ensure timeliness and quality of deliverables.
  • Review and validate CRO deliverables.
  • Other work as assigned by line manager.
  • Collaborate as the statistical subject matter expert with medical writers in the production of clinical reports, integrated summaries, and other documents.
  • Learn drug development regulatory requirements as they relate to statistics, including statistical contributions to marketing applications and CDISC SDTM and ADaM standards.
  • Stay current with new developments in statistics, drug development, and regulatory guidance through literature review, conference attendance, and other professional development activities.

Required Knowledge, Skills, and Abilities
  • Knowledge of clinical trial design and analysis, including experience with complex statistical methods and models, including statistical principles and methodology and principles of statistical inference, including hypothesis testing and deriving estimates, parametric and non-parametric models and techniques, principles of sample size calculations for comparing two arms, principles of design of experiments in introducing conditions designed to affect an outcome of interest, and phase II-IV clinical trial data analysis.
  • Experience in using SAS and R; knowledge of other statistical applications and programming languages a plus.
  • Knowledge of applicable regulatory requirements and guidelines, e.g., ICH Guidelines.
  • Able to work in a fast-paced, flexible, team-oriented environment.
  • Possess excellent interpersonal and communication skills (written and verbal).
  • Strong attention to detail with a view to bring studies to a quality conclusion.
  • Flexible, positive, creative thinker, good communicator.
  • Be able to work without close supervision with effective time management.

Required/Preferred Education and Licenses
  • MS or MPH in statistics, mathematics, or a related discipline with a statistical focus and > 2 years of experience in pharmaceutical or biotechnology industry.
  • PhD in statistics, mathematics, or a related discipline with a statistical focus and < 2 years of experience in the pharmaceutical or biotechnology industry.
  • Knowledge of drug development regulations pertinent to statistical analysis.
  • Bayesian and adaptive design knowledge is preferred.
  • Proficient SAS & R programming skills, understanding of CDISC models and standards.
  • Excellent writing and communication skills, demonstrated leadership abilities and excellent interpersonal skills.

#LI-Remote
Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law.
FOR US BASED CANDIDATES ONLY
Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is:
$132,000.00 - $198,000.00
Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis.
At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan.
The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here: https://careers.jazzpharma.com/benefits.html

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