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Principal Scientist Assay Development Jobs in Oregon

Medium

Assay Development Scientist

Portland, OR · On-site

$80 - $120/hr

As our Assay Development Scientist, you will be the primary architect of our internal molecular biology toolkit, transforming cutting‑edge academic and commercial protocols into robust, highly ...

Galois, Inc.

Principal Scientist

Portland, OR · On-site

About This Role Principal Scientists drive a research agenda and develop R&D opportunities at the intersection of Formal Methods and one or more of our four Research Areas : * Rigorous Digital ...

Galois, Inc.

Principal Scientist

Portland, OR

About This Role Principal Scientists drive a research agenda and develop R&D opportunities at the intersection of Formal Methods and one or more of our four Research Areas : * Rigorous Digital ...

A-dec, Inc.

Scientist, Principal

Newberg, OR · On-site

Overview The Principal Scientist serves as a senior technical leader responsible for identifying ... Provide technical leadership across concept development, validation, and transition to downstream ...

A-dec, Inc.

Scientist, Principal

Newberg, OR · On-site

Overview The Principal Scientist serves as a senior technical leader responsible for identifying ... Provide technical leadership across concept development, validation, and transition to downstream ...

A-dec, Inc. (USA)

Scientist, Principal

Newberg, OR · On-site

$120 - $160/hr

The Principal Scientist serves as a senior technical leader responsible for identifying, shaping ... Provide technical leadership across concept development, validation, and transition to downstream ...

e184

Scientist - Endometrial Biology

Portland, OR · On-site

$37.50 - $47/hr

Role overview As a Scientist at e184, you will lead research aimed at understanding the molecular ... assays to study signaling and structural interactions during implantation and early development ...

e184

Scientist - Endometrial Biology

Portland, OR

$37.50 - $47/hr

Role overview As a Scientist at e184, you will lead research aimed at understanding the molecular ... assays to study signaling and structural interactions during implantation and early development ...

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Principal Scientist Assay Development information

What does a principal scientist assay development do?

A Principal Scientist in Assay Development leads the design, optimization, and validation of assays used for research, diagnostics, or drug development. They oversee laboratory teams, develop protocols, and ensure that assays meet regulatory and quality standards. Their role also involves troubleshooting complex scientific problems, collaborating with cross-functional teams, and staying current with technological advances in assay technologies. Principal Scientists play a key role in translating scientific concepts into reliable, reproducible assays that support broader organizational goals.

What are some common challenges faced by principal scientists assay development, and how can they be addressed?

Principal Scientists in Assay Development often encounter challenges such as optimizing assay sensitivity and specificity, troubleshooting inconsistent results, and scaling up assays for high-throughput screening. Addressing these issues requires strong analytical thinking, effective cross-functional collaboration with research, engineering, and quality assurance teams, and staying updated with the latest technological advances. Regularly reviewing validation protocols and actively participating in peer discussions can also help in overcoming technical hurdles and ensuring robust assay performance.

What are the key skills and qualifications needed to thrive as a principal scientist assay development, and why are they important?

To thrive as a Principal Scientist Assay Development, you need advanced expertise in biochemistry or molecular biology, a PhD or equivalent experience, and a strong background in assay design and validation. Familiarity with laboratory automation, data analysis software, and regulatory compliance systems such as GLP/GMP is typically required. Leadership, project management, and effective communication are crucial soft skills for guiding teams and collaborating across departments. These skills ensure robust assay performance, regulatory adherence, and efficient innovation in complex scientific environments.

What is the difference between Principal Scientist Assay Development vs Senior Scientist Assay Development?

AspectPrincipal Scientist Assay DevelopmentSenior Scientist Assay Development
CredentialsAdvanced degree (PhD or equivalent), extensive experienceMaster's or PhD, significant industry experience
Work EnvironmentLeads assay development projects, strategic planningExecutes assay development tasks, supports project teams
Employer & Industry UsagePharmaceutical, biotech, CROs, biotech companiesPharmaceutical, biotech, research labs

The main difference between Principal Scientist Assay Development and Senior Scientist Assay Development lies in their level of responsibility and leadership. Principal Scientists typically lead projects, set strategies, and have more extensive experience, while Senior Scientists focus on executing assays and supporting project goals. Both roles require strong technical expertise, but the Principal Scientist position involves higher-level decision-making and oversight.

What are popular job titles related to Principal Scientist Assay Development jobs in Oregon?

For Principal Scientist Assay Development jobs in Oregon, the most frequently searched job titles are:

What job categories do people searching Principal Scientist Assay Development jobs in Oregon look for?

The top searched job categories for Principal Scientist Assay Development jobs in Oregon are:

What cities in Oregon are hiring for Principal Scientist Assay Development jobs?

Cities in Oregon with the most Principal Scientist Assay Development job openings:

Principal Scientist Assay Development jobs near you

Assay Development Scientist

Medium

Portland, OR • On-site

$80 - $120/hr

Other

Medical, Dental, Vision, Retirement, PTO

This job post has expired today. Applications are no longer accepted.

Job description

About us:

e184 Repro is a biotechnology research company with the mission of advancing in vitro gametogenesis to solve one of biology’s most profound challenges: returning the fundamental right to procreate.

We work at the frontier of cutting‑edge technology, integrating cellular reprogramming, machine learning‑guided optimization, multi‑omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges.

Role overview:

As our Assay Development Scientist, you will be the primary architect of our internal molecular biology toolkit, transforming cutting‑edge academic and commercial protocols into robust, highly standardized workflows. Your mission is to bridge the gap between “published methods” and “internal gold standards”. This role focuses on troubleshooting complex sample types, optimizing assays for low‑input requirements, and collaborating with our computational team to validate data quality through a rigorous feedback loop. Beyond the bench, you will evaluate emerging technologies, manage relationships with CROs, and spearhead our future transition toward automated liquid handling and miniaturized workflows. This is a role for a meticulous problem‑solver who is passionate about technical excellence.

What you’ll do
  • Architect the toolkit: Identify, internalize, implement, and optimize cutting‑edge assays (RNAseq, scRNAseq, ATACseq, ChIP‑seq, etc.) for our specific samples and instruments.
  • Push technology to the limit: Go beyond standard protocols and refine for ultra‑low input samples where standard methods fail.
  • Establish gold standards: Author company SOPs that ensure absolute reproducibility across the entire R&D team.
  • Drive technical QC: Partner with our computational experts to analyze sequencing data and help decide which techniques are best for our platform.
  • Bring the future: Develop new molecular biology technologies, demo high‑end equipment, and lead the charge toward miniaturization and automation via liquid handlers.
Core requirements
  • 5+ years of NGS mastery with deep, hands‑on experience in sample prep across RNAseq, DNAseq, single‑cell applications (scRNA‑seq, scATAC‑seq), and DNA methylation sequencing in a fast‑paced setting.
  • A proven track record of developing or heavily modifying assays for challenging contexts (low input, difficult sample types), not just following manual instructions.
  • Expert at interpreting Bioanalyzer/TapeStation traces and correlating library complexity with bench‑side variables.
  • Ability to translate complex technical trade‑offs into clear decisions for both scientists and engineers.
  • You are proactive, resourceful, obsessed with high‑quality data, and thrive in a startup environment of constant troubleshooting.
You’ll stand out with
  • Automation background with experience programming liquid handlers (Hamilton/Opentrons/Tecan).
  • A history of successfully miniaturizing reactions to slash costs while maintaining data integrity.
  • Experience setting up and running Illumina or Nanopore/PacBio sequencers in‑house.
Why e184?
  • Unrivaled impact: Your work directly enables technology that transforms human fertility and reproductive medicine.
  • Full‑range growth: Gain exposure to the entire lifecycle of discovery. From screening to mechanistic validation.
  • Best of both worlds: Experience the creative chaos of an early‑stage startup with the stability of a well‑capitalized company.
  • Elite collaboration: Work alongside a world‑class team who are as driven as you are.
What we offer
  • Competitive salary + equity participation is considered.
  • State‑of‑the‑art facility in Portland metro area.
  • Comprehensive Medical, Dental, Vision, and 401(k) with company match.
  • 20 days PTO + 11 paid holidays.
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