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Principal Process Engineer Jobs (NOW HIRING)

PerkinElmer

Principal Process Engineer

Collegeville, PA · On-site

Job Title Principal Process Engineer Location(s) GSK (Collegeville) - Customer Site PA We are seeking a highly motivated and ambitious candidate to join the PerkinElmer OneSource Scientific Services ...

ASM

Principal Process Engineer

Phoenix, AZ · On-site

As a Principal Process Engineer at ASM, you will work with semiconductor processing and analytical equipment to research, develop and optimize processes focused on oxidation, annealing, curing ...

Lancesoft INC

Principal Process Engineer

Wilson, NC · On-site

$65 - $71/hr

Senior/Principal Engineer for the Large Molecule Drug Substance (LMDS) project. Duration: 05/18 ... Drive innovative solutions in engineering support, and process technology. * Coordinate with ...

kindeva

Principal Process Engineer

Northridge, CA · On-site

$140K - $159K/yr

Principal Process Engineer for Kindeva Drug Delivery LP. LOCATION: 19901 Nordhoff St., Northridge, California 91324. JOB DUTIES: Provide technical support to process improvement initiatives on ...

kindeva

Principal Process Engineer

Northridge, CA · On-site

$140K - $159K/yr

Principal Process Engineer for Kindeva Drug Delivery LP. LOCATION: 19901 Nordhoff St., Northridge, California 91324. JOB DUTIES: Provide technical support to process improvement initiatives on ...

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$87K

$150.1K

$182.5K

How much do principal process engineer jobs pay per year?

As of Jun 18, 2026, the average yearly pay for principal process engineer in the United States is $150,082.00, according to ZipRecruiter salary data. Most workers in this role earn between $130,000.00 and $169,500.00 per year, depending on experience, location, and employer.

What engineers make $300,000 a year?

Senior engineers in specialized fields such as petroleum, aerospace, or software engineering can earn $300,000 or more annually, especially with extensive experience, advanced skills, and leadership roles. Principal Process Engineers in industries like oil and gas or chemical manufacturing may also reach this level with significant expertise and project management responsibilities.

What engineers make $500,000?

Principal Process Engineers in industries such as oil and gas, chemical manufacturing, or aerospace can earn $500,000 or more annually, especially with extensive experience, advanced skills, and leadership responsibilities. High compensation often includes bonuses, stock options, or profit sharing, particularly in large corporations or executive-level roles.

What are the key skills and qualifications needed to thrive as a Principal Process Engineer, and why are they important?

To thrive as a Principal Process Engineer, you need deep expertise in chemical or process engineering, advanced problem-solving skills, and typically a relevant engineering degree with substantial industry experience. Familiarity with process simulation software (such as Aspen HYSYS or CHEMCAD), Six Sigma or Lean certifications, and knowledge of regulatory standards are important technical assets. Leadership, effective communication, and project management skills distinguish top performers in this role. These competencies ensure efficient process design, regulatory compliance, and successful cross-functional collaboration on complex engineering projects.

What is the difference between Principal Process Engineer vs Process Engineer?

AspectPrincipal Process EngineerProcess Engineer
CredentialsBachelor's/Master's in Chemical, Mechanical, or Industrial Engineering; extensive experienceBachelor's degree in Engineering; entry to mid-level experience
Work EnvironmentLead projects, oversee process design, and mentor teams in manufacturing or chemical plantsAssist in process design, troubleshooting, and optimization under supervision
Industry UsageCommon in large manufacturing, chemical, and oil & gas companiesFound across various industries including manufacturing, pharmaceuticals, and energy

The Principal Process Engineer typically holds advanced credentials and leads complex projects, focusing on strategic process improvements. In contrast, the Process Engineer is more involved in supporting and executing process tasks. Both roles are essential in process industries, but the Principal Process Engineer operates at a higher level of responsibility and expertise.

What is a principal process engineer?

A principal process engineer is a senior-level professional responsible for designing, optimizing, and overseeing manufacturing or chemical processes within an organization. They often lead process improvement projects, utilize engineering tools like process simulation software, and require extensive technical expertise and experience in their field.

How much does a principal process engineer make in the US?

A principal process engineer in the US typically earns between $110,000 and $160,000 annually, with the median around $135,000. Compensation varies based on experience, industry, location, and company size, and often includes benefits such as bonuses and stock options.

How does a Principal Process Engineer typically collaborate with cross-functional teams during large-scale projects?

A Principal Process Engineer often acts as a key liaison between engineering, operations, project management, and quality assurance teams. They lead process design reviews, facilitate technical discussions, and ensure that project deliverables align with organizational goals and regulatory standards. Effective communication and coordination are essential, as they guide multidisciplinary teams through troubleshooting, optimization, and implementation phases. This collaborative role ensures that process improvements are feasible, cost-effective, and sustainable across the project lifecycle.

What Is a Principal Process Engineer?

A principal process engineer works with a team to analyze the efficiency of company processes and identify potential improvements. In this career, you usually work in a large production or manufacturing facility. You must have excellent technical, organizational, and analytical skills. Your job duties include helping management in the development of schedules, budgets, or guidelines for your department, overseeing other engineers, collaborating to support process solutions, and creating simulations, diagrams, and project plans. You also use engineering computer software to design process plans and review data to calculate constant improvements. Qualifications for a career as a principal process engineer include a bachelor's degree in engineering.

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Principal Process Engineer jobs near you
Infographic showing various Principal Process Engineer job openings in the United States as of June 2026, with employment types broken down into 6% As Needed, 88% Full Time, and 6% Part Time. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $150,082 per year, or $72.2 per hour.
Principal Process Engineer

Principal Process Engineer

PerkinElmer

Collegeville, PA • On-site

Full-time

Posted 2 days ago

PerkinElmer rating

8.5

Company rating: 8.5 out of 10

Based on 5 frontline employees who took The Breakroom Quiz

Job description

When joining PerkinElmer, you select an experienced and trusted leader in scientific solutions, with the support of a global service network and distribution centers, providing the right solution, at the right time, to meet critical customer needs. With over an 80+ year legacy of advancing science and a mission of innovating for a healthier world, our dedicated team collaborates closely with commercial, government, academic and healthcare customers to deliver our broad portfolio of analytical solutions, and OneSource services.
Job Title
Principal Process Engineer
Location(s)
GSK (Collegeville) - Customer Site PA
Job Description
We are seeking a highly motivated and ambitious candidate to join the PerkinElmer OneSource Scientific Services team based at one of our customer sites in Collegeville, PA.
The successful candidate will be working within the PerkinElmer Technical Lab Services (TLS) division and will be placed within a research unit at the customer site who have a focus on process engineering and modeling, supporting R&D and manufacturing activities and are at the forefront of developing innovative and life-changing medicines for patients.
The candidate will work within a collaborative team environment across a diverse biotherapeutic portfolio within the company and can develop in PerkinElmer's scientific arena. The role will report to the PerkinElmer Regional TLS Leader and will be based at the GSK Upper Providence campus.
Job Responsibilities
  • Conduct laboratory experimentation and analytical testing of putative formulations & drug products, and combination assessment in collaboration with device engineering.
  • Work on developing processes for lyophilized drug product dosage forms and other Steriles process development.
  • Platform development workstreams to assess, develop and implement new manufacturing platforms.
  • Drug Product technology transfer activities and reports as appropriate for transfer/scale-up to the manufacturing site (internal or external).
  • Preparation and review of developmental and manufacturing batch records, SOPs, and regulatory documentation as appropriate.
  • Automate developmental work packages and establish control strategies through the development and maintenance of system modeling platforms.
  • Make innovative contributions to the department by leading platform development workstreams to assess, develop and implement new manufacturing/PAT platforms, for example lyophilization. Be an expert and be accountable for manufacturing/PAT platform robustness across the portfolio.
  • Author reports relevant to Process Engineering and analytics platforms.
  • Track assay performance metrics and communicate issues and suggest improvements to current assay methodology, supporting evaluation of new technologies where applicable.
  • Comply with Health and Safety procedures for own well-being and quality of product.
  • Actively seek opportunities to develop the service by discussion with the team leader and customer or by sharing the best practice with other groups.
  • Act as an ambassador for TLS and promote PerkinElmer's core values.
  • Operate to approved quality standards.

Nothing in this job description restricts management's right to assign or reassign duties and responsibilities of this job at any time.
Critical Skills
  • Strong communication and interpersonal skills, both written and verbal.
  • Self-motivated and able to work under pressure to prioritize conflicting deadlines.
  • An ability to meet timelines successfully with the utmost attention to detail while setting high performance standards.
  • Service orientated attitude combined with innovative thinking.
  • Strong interpersonal skills; strong team player with customer satisfaction focus
  • Ability to execute new and established methods and protocols.
  • Ability to understand, interpret, and communicate complex scientific data.
  • Understanding of standard software packages (i.e. Microsoft Office).
  • Ability to operate within company and/or customer site safety codes of practice and adhere to data integrity principles.

Basic Qualifications
  • PhD in Pharmaceutical Sciences, Biotechnology, Chemistry, Biology, Physics, Chemical Engineering, mechanical engineering or any engineering field. Experience in Freeze Drying/Lyophilization highly desired.

OR
  • MS with 3+ years' experience in Pharmaceutical Sciences, Biotechnology, Chemistry, Biology, Physics, Chemical Engineering, mechanical engineering or any engineering field. Experience in Freeze Drying/Lyophilization highly desired.

OR
  • BS with 5+ years' experience in Pharmaceutical Sciences, Biotechnology, Chemistry, Biology, Physics, Chemical Engineering, mechanical engineering or any engineering field. Experience in Freeze Drying/Lyophilization highly desired.

Preferred Qualifications
  • Expertise in process development optimization, specifically lyophilized drug product manufacturing processes.
  • Publications in peer-reviewed journals.
  • Experience in Steriles drug product process development, PAT, characterization, scale -up and technology transfer, and modelling.
  • Experience in the application of state-of-the-art laboratory equipment, equipment automation, data automation, PAT tools and modelling software.
  • Experience evaluating, developing, and qualifying manufacturing equipment.
  • Proven ability to lead collaboratively in a matrix-style environment.
  • Knowledge of GCP, GCLP, GMP, and data integrity principles in the pharmaceutical environment.
  • Knowledge of 5S and/or 6 sigma principles is a plus.

Working Environment
  • Employees will be provided with PerkinElmer polo shirts to be worn when on site.
  • Must be able to work in a laboratory and controlled environments requiring personal protective equipment (e.g., lab coat, safety glasses, etc.).
  • Work with biohazards upon completion of blood borne pathogen surveillance.
  • Hepatitis B vaccination may be required, vaccination programme in place for successful candidates who are not already vaccinated or require updated boosters. Opt out optional.
  • Job pace may be fast and job completion demands may be high.
  • Must be able to remain in a stationary position more than 25% of the time
  • The person needs to occasionally move between laboratories, corridors, adjoining rooms, and buildings onsite. Occasional travel to other customer sites may be needed.
  • Frequently operate on instruments, objects, tools or controls, which will require regularly bending, squatting, stretching and reaching to perform in a service function.
  • Occasionally move or lift up to 25 pounds (potential for occasional lifting of up to 50 pounds).
  • Specific vision abilities required by this position include without limitation, the ability to observe details at close range distance vision, color vision, peripheral vision, depth perception, and ability to adjust focus to perform the essential service functions of this position.
  • Operation of a computer and other office machinery, such as a calculator, copy machine, and computer printer.
  • The employee may be required to manage hazardous waste in compliance with company procedures and local and national hazardous waste regulations. Duties may include identifying, handling, generating, accumulating, storing, labelling.
  • Potential risk to lab-based hazards including but not limited to extreme temperature, biological materials, and hazardous chemicals.
  • May be required to complete Medical Clearance, Respiratory Protection Training, and Fit Testing to wear a respirator as protection against hazards present in the laboratory environment.

The annual compensation range for this full-time position is $110,000 to $140,000. The final base pay offered to the successful candidate will be determined by factors including internal equity, work location, as well as individual qualifications, such as job-related skills, experience, and relevant education or training.
PerkinElmer is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability status, age, or veteran status or any other characteristics protected by applicable law. PerkinElmer is committed to a culturally diverse workforce.

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