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Principal Clinical Research Jobs (NOW HIRING)

Alcanza Clinical Research

$23.50 - $31.25/hr

The Clinical Research Coordinator under the direction of the Site Manager/Director and the Principal/Sub Investigators conducts the following according to the study protocol, company processes ...

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How much do principal clinical research jobs pay per hour?

As of Sep 15, 2026, the average hourly pay for principal clinical research in the United States is $43.09, according to ZipRecruiter salary data. Most workers in this role earn between $36.54 and $43.03 per hour, depending on experience, location, and employer.

What is a principal clinical research?

A Principal Clinical Researcher is a senior professional responsible for designing, overseeing, and managing clinical research studies, often within the pharmaceutical, biotechnology, or medical device industries. They ensure that all clinical trials adhere to regulatory guidelines, ethical standards, and scientific protocols. These experts lead research teams, coordinate with stakeholders, analyze data, and contribute to the development of new medical treatments or therapies. Their leadership is critical to the success of clinical studies and advancing medical knowledge.

What are the key skills and qualifications needed to thrive as a principal clinical research professional?

To thrive as a Principal Clinical Research professional, you need deep expertise in clinical trial design, regulatory compliance, data analysis, and a relevant advanced degree (such as PhD, PharmD, or MD). Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications like GCP (Good Clinical Practice) are typically required. Strong leadership, problem-solving abilities, and effective communication skills distinguish top performers in this role. These skills ensure studies are conducted ethically, efficiently, and in alignment with regulatory standards, ultimately advancing scientific and medical progress.

What are some common challenges faced by principal clinical research professionals in managing multicenter clinical trials?

Principal Clinical Research professionals often encounter challenges such as ensuring consistent protocol adherence across multiple study sites, managing large and diverse research teams, and coordinating communication among stakeholders. They must also navigate regulatory requirements that can vary by region and address data quality issues that arise from varying site performance. Effective leadership, strong organizational skills, and proactive problem-solving are essential for successfully managing these complex trials.

What is the difference between Principal Clinical Research vs Clinical Research Associate?

AspectPrincipal Clinical ResearchClinical Research Associate
Required CredentialsAdvanced degrees (e.g., MS, PhD), extensive experience, certifications like CCRPBachelor’s degree, clinical research training, certifications like CCRP or CCRA often preferred
Work EnvironmentLeadership role overseeing multiple studies, strategic planning, and team managementSite monitoring, data collection, ensuring protocol compliance at clinical sites
Employer & Industry UsagePharmaceutical companies, CROs, biotech firms, academic institutionsPharmaceutical companies, CROs, clinical trial sites

The Principal Clinical Research role involves strategic oversight, leadership, and extensive experience, whereas the Clinical Research Associate focuses on site monitoring and data collection. Both roles are essential in clinical trials, but they differ significantly in responsibilities and seniority.

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Principal Clinical Research jobs near you
Infographic showing various Principal Clinical Research job openings in the United States as of September 2026, with employment types broken down into 75% Full Time, and 25% Part Time. Highlights an 100% In-person job distribution, with an average salary of $89,619 per year, or $43.1 per hour.

100% Clinical Research / Medical Oncology Positions @ HonorHealth Research Institute in Scottsdale,

Scottsdale, AZ • On-site

HonorHealth
Health Care and Social Assistance • 10K+ employees
Learn more about HonorHealthexternal

Full-time

Re-posted 13 days ago

HonorHealth rating

7.7

Company rating: 7.7 out of 10

Based on 212 frontline employees who took The Breakroom Quiz

Job description

Medical Oncology 100% Clinical Research Positions

HonorHealth Research Institute

Scottsdale, Arizona

HonorHealth Research Institute the Division of Cancer Research is seeking Board Certified Medical Oncologists with interest in a 100% clinical research position with expertise in:

Melanoma and Solid Tumor Cellular Therapy to join a Cutaneous Oncology Program

Pancreatic cancer / GI malignancies

Women's Cancer Research Program lead for the Drug Development Program

BMT/Cellular Therapies Program

Join the preeminent Phase 1 Oncology Drug Development Program in the Southwest US

HonorHealth

HonorHealth is a non-profit healthcare system with nine hospitals spanning the Phoenix metro area. The newly created Center for Translational Science and designation as primary teaching affiliate for the new Arizona State University School of Medicine and Advanced Medical Engineering Center will provide Medical Oncology Clinical Investigator Physicians with access to unique platforms to advance their academic career in a research friendly system.

HonorHealth Research Institute (HRI)

HRI is seeking a Board-Certified Oncologist to be a principal Clinical Investigator in a unique setting where majority of your practice is dedicated to lead early phase clinical trials and participate in novel therapies and trials in collaboration with the clinical Oncology network. Small standard of care panels complement HRI’s dedication to clinical research.

Established in 2005, the HonorHealth Research Institute (HRI) is part of a nine-hospital integrated healthcare system in the Scottsdale/Phoenix metro area. The HRI Cancer Research Division is affiliated with HonorHealth Cancer Care, the largest community multi-specialty Cancer Care program in the region that delivers primary cancer care to approximately 1/3 of all newly diagnosed cancer patients in the Phoenix metropolitan area.

HRI’s new Center Translational Science will use new techniques and disciplines rooted in the molecular (DNA) basis of disease, the new Center for Translational Science will build on the Research Institute’s expertise in developing first-in-human clinical trials, immune-system therapies, cellular therapies, targeted therapies and others to develop treatments that attack diseases, while minimizing negative side effects that might compromise a patient’s health. The new center is seen as a worldwide bridge among scientists, researchers, and physicians in their pursuit of new diagnostics and therapeutics to benefit patients.

As a part of the regions only locally owned, locally managed non-profit healthcare system with an expansive cancer care footprint, HRI is dedicated to offering patients thoughtful, compassionate care and access to novel treatments through innovative clinical research. The focus of the Division of Cancer Research is on providing access to new and novel clinical trials for patients with relapsed and refractory cancer within the state of Arizona and across the United States. Our collaborators include global biopharmaceutical, biotechnology, medical device, and clinical research organizations.

HonorHealth Research Institute impacts the value and quality of patient care by accelerating innovation, while seamlessly integrating the latest science. HRI’s designated clinical research team is comprised of 7 Full-Time Clinical Research Oncologist, 100+ adjunct clinical investigator physicians and an enthusiastic staff of 50 + team members at any given time have about:

  1. 200 + Active Clinical Studies
  2. 50 New Clinical Studies annually
  3. 350-400 Subjects Enrolled in Clinical Studies

HRI Clinical Research Oncologists benefit from being a part of a community-based research program which has access to additional resources with reduced administrative layers and generous philanthropic support. Faculty have the opportunity to join the Arizona State University School of Medicine and Advanced Medical Engineering program as adjunct faculty where they serve as preceptors and lecturers for clinical rotations and pre-clinical courses.

The successful candidate will engage with community hematology/oncology partners in the Phoenix metropolitan area supporting expansion of access to current bispecific antibody options for lymphoma and multiple myeloma with a focus on disease or therapeutic approaches.

Responsibilities

  1. Provide clinical expertise in the conduct of clinical trials
  2. Build positive relationships with faculty at the HRI & HonorHealth Cancer Care Network
  3. Principal Investigators collaborates with support team to manage clinical trials, including clinical operations, patient engagement, and regulatory affairs
  4. Execute research protocols according to FDA regulations and GCP guidelines
  5. Evaluate patient’s eligibility for clinical trials
  6. Adherent to industry standards and training programs associated with clinical trials
  7. Publish and present at national conferences

Why Scottsdale?

  1. Scottsdale is part of the Phoenix metropolitan area, the 5th largest city in the U.S., offering a diverse, dynamic, and rapidly growing community.
  2. Top-Rated Schools: The area is home to A+ excelling public schools and nationally ranked charter schools, including BASIS Scottsdale (ranked among the best in the nation) and Great Hearts Academies, known for their rigorous classical education. Additionally, nearby Tempe offers language immersion K-12 schools, supporting cultural diversity and global learning opportunities.
  3. Cultural Diversity: Scottsdale is a welcoming, inclusive community with a vibrant mix of cultures, celebrated through multilingual education programs, international festivals, and a thriving arts scene.
  4. Unparalleled Lifestyle: Enjoy world-class dining, shopping, and entertainment in Old Town Scottsdale, as well as endless outdoor activities, from hiking in the McDowell Sonoran Preserve to golfing at championship courses.
  5. Thriving Community: Consistently ranked as one of the best places to live and work, Scottsdale offers a family-friendly environment, access to top-tier healthcare, and a strong medical community.

To learn more about HRI Clinical Research Oncology positions, please submit your CV for consideration or contact the HonorHealth Physician Recruitment Partner:

Laura Hays

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About HonorHealth

Sourced by ZipRecruiter

HonorHealth is a non-profit, local community healthcare system serving an area of 1.6 million people in the greater Phoenix area. The network encompasses six acute-care hospitals, an extensive medical group, outpatient surgery centers, a cancer care network, clinical research, medical education, a foundation, and community services with approximately 13,100 team members, 3,500 affiliated providers and nearly 700 volunteers. HonorHealth was formed by a merger between Scottsdale Healthcare and John C. Lincoln Health Network. HonorHealth's mission is to improve the health and well-being of those we serve.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

Scottsdale, AZ, US

Year founded

2014

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