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Principal Clinical Data Manager Jobs (NOW HIRING)

Rho Inc

Clinical Data Manager

As our next Clinical Data Manager, you will have the opportunity to work closely with the multidisciplinary project team across the life cycle of the project to ensure data management is thoughtfully ...

New

Collabera

Clinical Data Manager

Irvine, CA · On-site

Clinical Data Manager Location: Irvine, CA USA 92618 Duration: 12 months (Strong Possibility of Extension) Employment Type: W2 Contingent Worker SUMMARY OF POSITION: As a key member of the Global ...

SystImmune, Inc

Clinical Data Manager

Redmond, WA · On-site

$100K - $170K/yr

The Clinical Data Manager (CDM) plays a broad role in interfacing with clinical study teams, external partners, and vendors to design, configure, and test clinical database systems, conduct data ...

Systimmune

Clinical Data Manager

Redmond, WA · On-site

The Clinical Data Manager (CDM) plays a broad role in interfacing with clinical study teams, external partners, and vendors to design, configure, and test clinical database systems, conduct data ...

ZS

Clinical Data Manager

Philadelphia, PA · On-site

ZS is seeking a Tech Project Delivery Manager to lead a high-velocity team focused on the future of Biometrics and Clinical Data. We are looking for a delivery leader who excels at navigating the ...

Systimmune

Clinical Data Manager

Redmond, WA · On-site

$100K - $170K/yr

The Clinical Data Manager (CDM) plays a broad role in interfacing with clinical study teams, external partners, and vendors to design, configure, and test clinical database systems, conduct data ...

Clinovo

Sr Clinical Data Manager

Waltham, MA · On-site

The Senior Clinical Data Manager will be responsible for the oversight, coordination, and execution of clinical data management activities across one or more clinical trials. This individual will ...

Novellia

Clinical Data Manager

New York, NY · On-site

$115K - $145K/yr

About the Role We are looking for a Clinical Data Manager to accelerate Novellia's data curation and delivery processes. In this role, you will be responsible for working with a team of cross ...

CYNET SYSTEMS

Clinical Data Manager

Maple Grove, MN · On-site

$41 - $46/hr

Education and work experience in project management, life sciences and/or technical field. * Knowledge of data collection best practices for clinical trials. * Knowledge of global clinical operations.

Novellia

Clinical Data Manager

Manhattan, NY · On-site

About the Role We are looking for a Clinical Data Manager to accelerate Novellia's data curation and delivery processes. In this role, you will be responsible for working with a team of cross ...

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Principal Clinical Data Manager information

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How much do principal clinical data manager jobs pay per hour?

As of Sep 11, 2026, the average hourly pay for principal clinical data manager in the United States is $57.17, according to ZipRecruiter salary data. Most workers in this role earn between $45.19 and $68.03 per hour, depending on experience, location, and employer.

What does a principal clinical data manager do?

A Principal Clinical Data Manager oversees the collection, processing, and management of clinical trial data to ensure its accuracy, integrity, and compliance with regulatory standards. They lead data management teams, develop data management plans, and coordinate with other clinical project stakeholders. Their responsibilities also include reviewing data for consistency, resolving discrepancies, and ensuring that final databases are ready for statistical analysis and regulatory submission. Principal Clinical Data Managers play a key role in ensuring the quality and reliability of data used to evaluate new medical treatments.

How does a principal clinical data manager typically collaborate with cross-functional teams during a clinical trial?

A Principal Clinical Data Manager frequently partners with clinical operations, biostatistics, medical writers, and regulatory affairs throughout the clinical trial process. They coordinate data collection and validation activities, ensure data quality standards are met, and facilitate clear communication between departments. This role often leads data review meetings, addresses data discrepancies, and supports protocol adherence, making strong collaboration and leadership skills essential for project success.

What are the key skills and qualifications needed to thrive as a principal clinical data manager, and why are they important?

To thrive as a Principal Clinical Data Manager, you need expertise in clinical data management, regulatory compliance (such as GCP), and often a degree in life sciences or a related field. Familiarity with data management systems like Medidata Rave, Oracle Clinical, and knowledge of CDISC standards are typically required, along with certifications like CCDM. Leadership, attention to detail, and strong communication skills help in managing teams and collaborating across functions. These skills ensure data integrity, regulatory adherence, and efficient clinical trial outcomes in a highly regulated industry.

What is the difference between Principal Clinical Data Manager vs Clinical Data Manager?

AspectPrincipal Clinical Data ManagerClinical Data Manager
CredentialsBachelor's/Master's in Life Sciences, Biostatistics, or related field; experience in clinical data managementBachelor's in Life Sciences or related field; some experience in data management
Work EnvironmentLeads data management teams, oversees projects, collaborates with cross-functional teamsPerforms data entry, database setup, and data validation tasks
Employer & IndustryPharmaceutical, biotech, CROsPharmaceutical, biotech, CROs

The Principal Clinical Data Manager typically has more leadership responsibilities and oversees data management processes, while the Clinical Data Manager focuses on executing data entry and validation tasks. Both roles are essential in clinical trials within the pharmaceutical and biotech industries, but the principal role involves higher-level oversight and strategic planning.

What cities are hiring for Principal Clinical Data Manager jobs?

Cities with the most Principal Clinical Data Manager job openings:

Who are the top companies hiring for Principal Clinical Data Manager jobs?

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What states have the most Principal Clinical Data Manager jobs?

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What are popular job titles related to Principal Clinical Data Manager jobs?

For Principal Clinical Data Manager jobs, the most frequently searched job titles are:

Principal Clinical Data Manager jobs near you
Infographic showing various Principal Clinical Data Manager job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 11% Part Time, and 1% Contract. Highlights an 80% Physical, 2% Hybrid, and 18% Remote job distribution, with an average salary of $118,909 per year, or $57.2 per hour.

Clinical Data Manager

Boston, MA • On-site

Katalyst HealthCares & Life Sciences
Scientific Research and Development Services • 51 - 200 employees
Learn more about Katalyst HealthCares & Life Sciencesexternal

Full-time

Posted 12 days ago

Job description

Job Title

Responsibilities

  • Act as primary liaison between Company and CRO for Data Management.
  • Provide support and oversight for the CRO Data Management team.
  • Collaborate with the team on study design, protocol development, CRF design, statistical planning, and CSRs.
  • Review clinical study protocols and provide comments if any.
  • Provide leadership and support for cross-functional tasks, processes, and training.
  • Provide oversight and manage relationships with external vendors.
  • Responsible for reviewing the data management documentation, data management plan (DMP), CRF, study database specifications, data validation plan, edit check specifications, data transfer specifications, data issue logs, data review plans and ensures all documents follow study design and regulatory requirements.
  • Perform User acceptance testing for EDC.

Requirements

  • Master's degree or higher in science or related discipline.
  • Minimum of 5 years of CDM experience in pharmaceutical/biotech industry.
  • Practical experience with successful submissions and product approvals from global regulatory authorities across multiple therapeutic areas.
  • Thorough and broad knowledge of data management processes, including EDC and interactive web response system (IWRS) experience.
  • Good working knowledge of regulatory guidelines such as GCP, 21 CFR Part 11, etc.
  • Solid understanding of clinical research methods, Clinical Data Interchange Standards Consortium (CDISC) principles, best data management practices and technologies related to clinical trials.
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About Katalyst Healthcares & Life Sciences

Sourced by ZipRecruiter

Katalyst HealthCares & Life Sciences is a Global Contract Research Organization that provides services in Clinical Research, Manufacturing & Quaity, Regulatory Affairs Areas.. Industries Serving: Pharmaceutical Bio-Pharmaceutical Medical Device Cosmeceuticals & Cosmetics Food & Beverage Clinical Research Scientific Areas Covering: Clinical Research Manufacturing Quality & Validations Regulatory Affairs Intellectual Property Through our in-house team expertise, associates and alliances in the US, Europe and Asia, we can rapidly deliver services, technology, processes and workforce globally, either virtually or integrate into client project space, providing oversight and expertise for individual needs to total end-to-end support for all kinds of clinical trials of Pharma, Biotech, Medical Device and all other scientific products and their manufacturing.

Industry

Scientific research and development services

Company size

51 - 200 Employees

Headquarters location

South Plainfield, NJ, US

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