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Phd Cryo Electron Microscopy Jobs (NOW HIRING)

University of Colorado

Post-Doctoral Fellow

Aurora, CO · On-site

$49K - $67K/yr

... as cryo-electron microscopy, tomography, kinetic assays, and computational analysis. Day-to-day ... Applicants must meet minimum qualifications at the time of hire. • PhD or equivalent doctoral ...

University of Colorado

Post-Doctoral Fellow

Aurora, CO

$49K - $67K/yr

PhD or equivalent doctoral degree in Structural Biology, Virology, or a closely related field ... Expertise in cryo-electron microscopy (cryo-EM), cryo-electron tomography (cryo-ET), Tomography, or ...

Umd

Post-Doctoral Associate

College Park, MD

$62K - $75K/yr

... cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron ... Applicants must hold a PhD in biophysics, biochemistry, structural biology, or a closely related ...

Ohio State University

$46K - $63K/yr

Minimum Education and Skills/Experience Required/Desired A PhD in biochemistry, cell biology ... electron microscopy (cryo-EM) or cryo-electron tomography (cryo-ET), structural biology ...

New

NANOSCIENCE INSTRUMENTS INC

$90 - $130/hr

Minimum BS; MS or PhD preferred, in Chemistry, Physics, Materials Science or Engineering or related area * Experience: Hands on proficiency with Scanning Electron Microscopy, EDS/EDX, and Python

New

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Phd Cryo Electron Microscopy information

What is a PhD in cryo electron microscopy?

A PhD in Cryo-Electron Microscopy (Cryo-EM) is a doctoral program focused on using advanced electron microscopy techniques to study the structures of biological molecules at near-atomic resolution. Students in this field develop expertise in sample preparation, imaging, and data analysis to better understand the form and function of proteins, viruses, and other complex biomolecules. Graduates often contribute to scientific research in fields such as structural biology, biochemistry, and drug discovery.

What are the key skills and qualifications needed to thrive as a PhD cryo electron microscopy specialist?

To thrive as a PhD Cryo Electron Microscopy (Cryo-EM) specialist, you need a strong background in structural biology, biochemistry, and physics, typically supported by a doctoral degree in a related field. Expertise in operating advanced cryo-EM instruments, image processing software (such as RELION or CryoSPARC), and familiarity with data analysis pipelines is essential. Attention to detail, problem-solving ability, and effective collaboration skills help you excel when troubleshooting experiments and working within multidisciplinary teams. These competencies are crucial for generating high-quality structural data and advancing scientific discoveries in molecular biology.

What are some common challenges faced by PhD researchers specializing in cryo electron microscopy, and how can they be addressed?

PhD researchers in Cryo Electron Microscopy (Cryo-EM) often encounter challenges such as sample preparation issues, data collection bottlenecks, and interpreting complex datasets. Achieving optimal sample vitrification and minimizing beam-induced motion are technical hurdles that require patience and meticulous technique. Collaborating closely with experienced microscopists, leveraging advanced image processing software, and participating in specialized training workshops can greatly assist in overcoming these obstacles. Additionally, working in multidisciplinary teams fosters knowledge sharing and accelerates problem-solving, making it easier to advance high-impact structural biology projects.

What is the difference between Phd Cryo Electron Microscopy vs Phd Structural Biology?

AspectPhd Cryo Electron MicroscopyPhd Structural Biology
Required CredentialsPhD in relevant field, microscopy expertisePhD in biology, biochemistry, or related field
Work EnvironmentLaboratories with advanced microscopy equipmentResearch labs, academic institutions, biotech companies
Industry UsageUsed for high-resolution imaging of biomoleculesUsed for understanding biological structures and functions
Common Search/ComparisonOften compared for research focus and techniquesBroader biological context

While both roles require advanced degrees and involve biological research, Phd Cryo Electron Microscopy specializes in imaging techniques to visualize biomolecules at near-atomic resolution. Phd Structural Biology encompasses a broader understanding of biological structures, often integrating various methods including cryo-EM. The choice depends on whether the focus is on imaging technology or biological function analysis.

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Phd Cryo Electron Microscopy jobs near you
Infographic showing various Phd Cryo Electron Microscopy job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 89% Full Time, 7% Part Time, and 3% Contract. Highlights an 83% Physical, 5% Hybrid, and 12% Remote job distribution.

Research Associate II, Structural & Cellular Biology (Proteomics & CryoET)

Biohub

Redwood City, CA • On-site, Remote

Full-time

Retirement, PTO

Posted 21 days ago

Key responsibilities

  • Maintain, seed, and harvest human iPSC and mammalian cell lines for proteomics and imaging workflows.

  • Prepare samples for proximity labeling, immunoprecipitation, crosslinking mass spectrometry, cryoET, and CLEM experiments.

  • Assist with cryo FIB milling, cryoET data collection, tomogram reconstruction, and visualization.

Job description

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.
Our Vision
  • We pursue large scientific challenges that cannot be pursued in conventional environments
  • We enable individual investigators to pursue their riskiest and most innovative ideas
  • The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond
    Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

This role sits at the interface of two closely connected efforts within our Dynamic Structural Biology group, which maps the molecular architecture of living cells - charting how protein complexes assemble, where they localize, and how their organization shifts across cell states and in response to perturbation. We develop and operate advanced imaging workflows to resolve the structure of signaling organelles such as primary cilia and lysosomes. Together we develop and deploy cutting-edge cryo-electron tomography, proteomics, and correlative imaging approaches in mammalian cell line models to connect molecular interactomes to cellular architecture, function, and disease.
The Opportunity
Biohub is seeking a skilled and motivated Research Associate II to support our structural and cellular biology programs across proteomics and cryo-electron tomography. This is a hands-on bench role at the intersection of stem cell and mammalian cell biology, genome engineering, proteomics technology development, and advanced cryo-electron microscopy. You will maintain and engineer cell lines, design and optimize sample-preparation workflows for both mass spectrometry and cryoET, and help implement proximity labeling, crosslinking, correlative light and electron microscopy (CLEM), and FIB-SEM lamella preparation to map protein interaction networks and cellular architecture.
This position is well suited for candidates who enjoy hands-on experimental work, thrive in collaborative and fast-paced research environments, and are excited to contribute to biological discovery through the development and operation of advanced proteomics and imaging workflows. You will work closely with other scientists of diverse backgrounds in a fast-moving, collaborative environment where your contributions directly shape the team's scientific output.
What You'll Do
  • Maintain, seed, and harvest human iPSC and mammalian cell lines for downstream proteomics and imaging workflows.
  • Engineer and validate cell lines for proteomics assays (CRISPR endogenous tagging, lentiviral overexpression) .
  • Prepare samples for proximity labeling (e.g., TurboID) and immunoprecipitation plus crosslinking mass spec.
  • Prepare cell samples for cryoET and correlative light and electron microscopy (CLEM) experiments including transfections and fluorescence labeling.
  • Prepare vitrified samples using cryogenic freezing methods such as plunge freezing and high pressure freezing.
  • Perform cryo FIB milling on vitrified cellular samples using FIB-SEM instruments.
  • Assist with cryoET data collection, tomogram reconstruction, and visualization.
  • Work with team members to improve the throughput, reliability, and scalability of proteomics and imaging assays.
  • Maintain rigorous documentation of protocols, experimental conditions, results, sample tracking, and reagent inventory.
  • Contribute to publications and present findings internally and at scientific conferences.
What You'll Bring
Essentials
  • Bachelor's or Master's degree in Cell Biology, Biochemistry, Bioengineering, Molecular Biology, or a related discipline (or equivalent experience).
  • 2 years of experience in an RA I position, or 4 years of relevant, post-graduate research experience.
  • Experience maintaining mammalian and/or human pluripotent stem cell lines, with strong sterile technique and familiarity with culture best practices and quality control.
  • Experience with light or fluorescence microscopy.
  • Strong organizational skills and meticulous attention to detail across complex, multi-step experimental workflows.
  • A dynamic, adaptable, and self-motivated approach, with strong communication skills and the ability to work effectively in a collaborative team.
  • Enthusiasm for learning new techniques and contributing to cutting-edge, cross-disciplinary research.

Nice to have
  • Experience with immunoprecipitations, western blotting, and proteomics sample-preparation workflows.
  • Hands-on experience with proximity labeling approaches (TurboID, BioID, APEX).
  • Hands-on experience with CRISPR-based genome editing, including sgRNA and donor design.
  • Experience with cryogenic sample preparation, electron microscopy workflows, and/or operating or supporting FIB-SEM instrumentation.
  • Exposure to cryo-electron tomography and protein structure prediction.
  • Experience with coding (Python, R, etc.) for analysis of omics datasets, or with basic image/data processing and annotation workflows.
Compensation
The Redwood City, CA base pay range for a new hire in this role is $83,000.00 - $103,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.
Benefits for the Whole You
We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
  • Provides a generous employer match on employee 401(k) contributions to support planning for the future.
  • Paid time off to volunteer at an organization of your choice.
  • Funding for select family-forming benefits.
  • Relocation support for employees who need assistance moving

If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
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