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How much do pharmacometrics modeling jobs pay per hour?

As of Aug 15, 2026, the average hourly pay for pharmacometrics modeling in the United States is $40.33, according to ZipRecruiter salary data. Most workers in this role earn between $31.25 and $43.51 per hour, depending on experience, location, and employer.

What is the difference between Pharmacometrics Modeling vs Pharmacovigilance Specialist?

AspectPharmacometrics ModelingPharmacovigilance Specialist
Required credentialsAdvanced degrees in pharmacology, biostatistics, or related fields; often requires modeling certificationsDegree in pharmacy, medicine, or life sciences; certifications in drug safety or pharmacovigilance
Work environmentResearch-focused, data analysis, modeling teams within pharma companies or CROsMonitoring drug safety, reporting adverse events, compliance within regulatory agencies or pharma companies
Industry usageUsed in drug development to optimize dosing and efficacyUsed in post-marketing surveillance and safety monitoring

While both roles are essential in the pharmaceutical industry, Pharmacometrics Modeling focuses on quantitative analysis to optimize drug dosing and efficacy during development. Pharmacovigilance Specialists concentrate on monitoring and ensuring drug safety after approval. Both roles require specialized knowledge but serve different stages of the drug lifecycle.

What is pharmacometrics modeling?

Pharmacometrics modeling is a scientific discipline that applies mathematical and statistical models to describe, analyze, and predict the interactions between drugs, disease processes, and patient responses. These models help in understanding drug behavior in the body (pharmacokinetics) and the effects drugs have on the body (pharmacodynamics). Pharmacometrics is used extensively in drug development to optimize dosing, improve clinical trial designs, and support regulatory decision-making. Professionals in this field collaborate closely with clinicians, statisticians, and regulatory agencies to ensure safe and effective drug therapies.

What are the typical challenges faced when collaborating with cross-functional teams in pharmacometrics modeling?

Pharmacometrics modelers often work closely with clinicians, statisticians, and regulatory teams to translate complex data into actionable insights. A common challenge is ensuring clear communication, as different teams may have varying levels of familiarity with modeling concepts and terminology. Balancing scientific rigor with practical application is also crucial, especially when timelines are tight or data is limited. Proactive collaboration and adaptability are key to overcoming these challenges and ensuring effective integration of modeling results into drug development decisions.

What are the key skills and qualifications needed to thrive as a pharmacometrics modeler?

To thrive as a Pharmacometrics Modeler, you need strong quantitative skills, a background in pharmacology or a related field, and typically an advanced degree (MS or PhD) in pharmaceutical sciences, statistics, or mathematics. Expertise in modeling software such as NONMEM, Monolix, or R, along with familiarity with PK/PD modeling and regulatory guidelines, is crucial. Analytical thinking, problem-solving abilities, and effective communication are important soft skills for collaborating with multidisciplinary teams and presenting complex data. These skills ensure the accurate analysis and interpretation of drug data, supporting optimal drug development and regulatory decisions.

What cities are hiring for Pharmacometrics Modeling jobs?

Cities with the most Pharmacometrics Modeling job openings:

What states have the most Pharmacometrics Modeling jobs?

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What job categories do people searching Pharmacometrics Modeling jobs look for?

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Pharmacometrics Modeling jobs near you
Infographic showing various Pharmacometrics Modeling job openings in the United States as of August 2026, with employment types broken down into 87% Full Time, 10% Part Time, and 3% Contract. Highlights an 84% Physical, 5% Hybrid, and 11% Remote job distribution, with an average salary of $83,896 per year, or $40.3 per hour.

Director, Pharmacometrics & Clinical Pharmacology

Arrowhead Pharmaceuticals

Madison, WI • On-site

Full-time

Re-posted 7 hours ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking a Director of Pharmacometrics and Clinical Pharmacology to provide strategic and scientific leadership across the company's clinical development programs. This senior-level role is responsible for advancing pharmacometric and clinical pharmacology strategies to support the global development and regulatory submission of Arrowhead's leading siRNA therapeutics.
The Director will play a critical role in clinical trial design, data analysis, regulatory documentation, and cross-functional decision-making, ensuring that dosing strategies and clinical pharmacology plans are scientifically rigorous and aligned with regulatory expectations.
Responsibilities
  • Serve as the pharmacometrics and clinical pharmacology lead across multiple development programs within Arrowhead's RNAi therapeutic portfolio.
  • Lead model-informed drug development strategies, including population PK/PD analyses, exposure-response analyses, translational modeling, dose optimization, and quantitative interpretation of clinical and translational data.
  • Develop and support clinical pharmacology strategies for first-in-human studies, dose escalation and optimization, proof-of-concept studies, drug-drug interaction assessments, food effect studies, and special population evaluations.
  • Provide scientific leadership and oversight for PK/PD analyses and modeling activities conducted internally and through external CRO partners.
  • Contribute to global regulatory submissions and health authority interactions, including INDs, CTAs, NDA/BLA submissions, briefing documents, and responses to agency questions.
  • Author and review clinical pharmacology content for Investigational Brochures (IBs), clinical protocols, Clinical Study Reports (CSRs), and regulatory submission documents.
  • Collaborate closely with Clinical Development, Translational Sciences, Regulatory Affairs, Biometrics, Biomarkers, Medical Affairs, and Program Leadership teams to support program strategy and execution.
  • Present quantitative analyses, development strategies, and recommendations to project teams and senior leadership.
  • Maintain current knowledge of evolving scientific methodologies, regulatory guidance, and industry trends related to pharmacometrics, clinical pharmacology, and RNAi therapeutics.

Requirements
  • PhD or equivalent advanced degree in Pharmacokinetics, Pharmacology, Pharmaceutical Sciences, Biomedical Engineering, Applied Mathematics, or related quantitative discipline.
  • 12+ years in pharmacometrics and/or clinical pharmacology, including experience supporting late-stage development programs and global regulatory submissions.
  • Deep expertise in population PK/PD modeling and simulation with strong proficiency in industry-standard software such as NONMEM.
  • Strong understanding of exposure-response analysis, translational modeling, dose optimization, and model-informed drug development principles.
  • Experience supporting regulatory interactions with FDA, EMA, and other global health authorities.
  • Knowledge of PBPK, QSP, mechanistic modeling, or systems pharmacology approaches is highly desirable.
  • Prior experience with oligonucleotide, RNAi, rare disease, liver-targeted therapeutics, or other complex biologic modalities is preferred.
  • Demonstrated ability to independently lead complex scientific initiatives and influence cross-functional teams in a matrixed environment.
  • Excellent communication and presentation skills, with the ability to clearly communicate complex quantitative concepts to scientific and non-scientific audiences.

Preferred
  • Familiarity with PBPK/PD or quantitative systems pharmacology (QSP) modeling

Wisconsin pay range
$200,000-$230,000 USD
California pay range
$230,000-$255,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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