Office RNs work in a medical office or clinic setting, treating patients and assisting physicians. As an office registered nurse, you perform patient assessments, record vitals, and update patient records. You work with a doctor to provide education on procedures, answering questions and arranging for follow-ups visits. As an RN in a medical office, you tend to have the most face-to-face time with a patient. Your responsibilities include data entry, providing basic care, and helping patients understand and follow the doctor’s orders.