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Nucleic Acid Jobs (NOW HIRING)

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Senior Scientist, Bioanalytical Sciences

Cambridge, MA · On-site

$100K - $136K/yr

You will be a subject matter expert in nucleic acid and protein bioanalysis, working to generate critical data that informs decision-making across preclinical and clinical development. You will be ...

Virchow Medical, Inc

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Molecular Laboratory Technician

San Diego, CA · On-site

$24 - $34/hr

Perform nucleic acid purification using the Thermo Fisher Scientific KingFisherTM Apex Purification System. * Quantify extracted DNA using a QubitTM fluorometer. * Prepare reagents, buffers ...

System One

Biochemist/Molecular Biologist

Cambridge, MA · On-site

$35 - $41.82/hr

Ideal candidates should have a strong background in molecular biology techniques and experience with nucleic acid production and analysis. Responsibilities * Independently execute high-throughput ...

Roche

Intellectual Property/Patent Attorney

Pleasanton, CA · On-site +1

$186K - $346K/yr

Experience in patenting nucleic acid detection methods and nucleic acid chemistry, and preferably, next-generation nucleic acid sequencing methods and reagents, protein engineering * Contract and ...

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Nucleic Acid information

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$66.5K

$110.5K

$164.5K

How much do nucleic acid jobs pay per year?

As of Sep 13, 2026, the average yearly pay for nucleic acid in the United States is $110,545.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,500.00 and $125,000.00 per year, depending on experience, location, and employer.

What does a nucleic acid professional do?

Nucleic acid professionals are scientists or technicians who specialize in the study and manipulation of nucleic acids, such as DNA and RNA. Their work often involves extracting, analyzing, synthesizing, or modifying these molecules for research, diagnostics, or therapeutic purposes. They may work in fields like molecular biology, genetics, biotechnology, or medical diagnostics, using techniques like PCR, sequencing, or gene editing. Their expertise is crucial for understanding genetic information, developing new medical treatments, and advancing scientific research.

What are the key skills and qualifications needed to thrive as a nucleic acid scientist?

To thrive as a Nucleic Acid Scientist, you need expertise in molecular biology, nucleic acid extraction, and quantitative analysis, typically backed by an advanced degree in biology, biochemistry, or a related field. Familiarity with PCR, qPCR, electrophoresis, and bioinformatics tools is crucial in this role. Strong analytical thinking, attention to detail, and effective teamwork skills help ensure robust experimental design and data interpretation. These abilities are vital to advance research, ensure data accuracy, and contribute meaningfully to scientific discovery and biotechnology innovation.

What are some common challenges faced by scientists working with nucleic acids in a laboratory setting?

Scientists working with nucleic acids often encounter challenges such as sample degradation, contamination, and maintaining RNase- and DNase-free environments. Precise pipetting and careful handling are critical, as even minor errors can impact the integrity and yield of nucleic acids. Collaboration with team members for troubleshooting, sharing best practices, and optimizing protocols is essential for overcoming these hurdles and ensuring successful experimental outcomes.

What is the difference between Nucleic Acid vs Molecular Biologist?

AspectNucleic AcidMolecular Biologist
Required CredentialsLaboratory training, molecular biology certificationsAdvanced degrees (BSc, MSc, PhD) in biology or related fields
Work EnvironmentResearch labs, biotech companies, healthcare settingsResearch institutions, universities, biotech firms
Industry UsageFocuses on nucleic acid extraction, analysis, and manipulationStudies genetic mechanisms, gene expression, and molecular processes

While Nucleic Acid specialists focus on working with DNA and RNA molecules, Molecular Biologists study broader genetic and molecular mechanisms. Both roles often overlap in research settings, but Nucleic Acid professionals typically specialize in laboratory techniques related to nucleic acids, whereas Molecular Biologists may engage in more comprehensive genetic research and analysis.

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Nucleic Acid jobs near you
Infographic showing various Nucleic Acid job openings in the United States as of September 2026, with employment types broken down into 3% As Needed, 69% Full Time, 25% Part Time, 2% Contract, and 1% Nights. Highlights an 76% Physical, 1% Hybrid, and 23% Remote job distribution, with an average salary of $110,545 per year, or $53.1 per hour.

Oligonucleotide Scientist II

South San Francisco, CA • On-site

Software Guidance & Assistance
Health Care and Social Assistance • 51 - 200 employees
Learn more about Software Guidance & Assistanceexternal

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This job post has expired 1 day ago. Applications are no longer accepted.

Job description

Software Guidance & Assistance, Inc., (SGA), is searching for an Oligonucleotide Scientist II for a contract assignment with one of our premier Pharmaceutical clients in South San Francisco, CA .
Responsibilities :
We are seeking a creative, self-motivated, collaborative Scientist-II to join the Nucleic Acid Design and Discovery (NADD) team within ProteinSciences (PS) department at the firm. We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.
  • Will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy.
  • Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.
  • Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
  • Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
  • Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.
Required Skills :
  • Must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.
  • The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.
  • Good communication and interpersonal skills are essential and will be evaluated during the interview process.
  • The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication and organizational skills.
Preferred Skills :
  • Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
  • The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
  • A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action is preferred. Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.
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SGA is a technology and resource solutions provider driven to stand out. We are a women-owned business. Our mission: to solve big IT problems with a more personal, boutique approach. Each year, we match consultants like you to more than 1,000 engagements. When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work. Please find us at .
SGA is an Equal Opportunity Employer and does not discriminate on the basis of Race, Color, Sex, Sexual Orientation, Gender Identity, Religion, National Origin, Disability, Veteran Status, Age, Marital Status, Pregnancy, Genetic Information, or Other Legally Protected Status. We are committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, and our services, programs, and activities. Please visit our company to request an accommodation or assistance regarding our policy.
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