ZipRecruiter

Log In

1

Modeling And Simulation Jobs in Massachusetts (NOW HIRING)

Vrtx

Modeling & Simulations Director

Boston, MA · Hybrid

$194K - $291K/yr

By using state of the art Modeling & Simulation methodologies strongly contribute to critical decision making like study design, dose selection, probability of success estimation etc. * Independently ...

New

Vrtx

Modeling & Simulations Associate Director

Boston, MA · Hybrid

$168K - $252K/yr

By using state of the art Modeling & Simulation methodologies strongly contribute to critical decision making like study design, dose selection, probability of success estimation etc. * Independently ...

Amgen

Senior Engineer - Modeling & Simulation

Cambridge, MA · On-site

$114K - $156K/yr

Promote modeling and simulation best practices across the organization. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek ...

Vrtx

Modeling & Simulations Associate Director

Boston, MA · Hybrid

$168K - $252K/yr

By using state of the art Modeling & Simulation methodologies strongly contribute to critical decision making like study design, dose selection, probability of success estimation etc. * Independently ...

next page

Showing results 1-20

All JobsModeling And Simulation JobsModeling And Simulation Jobs in Massachusetts

Modeling And Simulation information

See Massachusetts salary details

$42.6K

$110.6K

$157.3K

How much do modeling and simulation jobs pay per year?

As of Aug 22, 2026, the average yearly pay for modeling and simulation in Massachusetts is $110,583.00, according to ZipRecruiter salary data. Most workers in this role earn between $85,700.00 and $141,400.00 per year, depending on experience, location, and employer.

What is a modeling and simulation job?

Modeling and simulation jobs involve creating digital or mathematical models to represent real-world systems, processes, or phenomena, and then using simulations to analyze their behavior under various scenarios. Professionals in this field use specialized software and computational techniques to predict outcomes, optimize designs, and inform decision-making in industries like engineering, defense, healthcare, and manufacturing. These roles often require strong analytical skills, proficiency in programming, and a background in mathematics or science. Modeling and simulation experts help organizations save time and resources by testing ideas virtually before applying them in real life.

What are the key skills and qualifications needed to thrive as a modeling and simulation specialist?

To thrive as a Modeling and Simulation Specialist, you need strong analytical abilities, proficiency in mathematics, and a background in computer science or engineering, often supported by a relevant degree. Expertise with simulation software (such as MATLAB, Simulink, or Arena), programming languages (like Python or C++), and knowledge of modeling standards is typically required. Critical thinking, problem-solving, and effective communication are essential soft skills for interpreting data and collaborating with multidisciplinary teams. These skills ensure accurate models, effective simulations, and actionable insights that drive decision-making in complex systems.

What are some common challenges faced by professionals in modeling and simulation roles, and how can they be addressed?

Professionals in Modeling and Simulation often encounter challenges such as integrating complex data from multiple sources, ensuring model accuracy, and communicating technical results to non-technical stakeholders. Addressing these challenges typically involves close collaboration with subject matter experts, ongoing model validation and verification, and using clear visualizations to explain insights. Building strong interdisciplinary communication skills and staying current with evolving simulation tools can also help professionals effectively navigate these challenges.

What is the difference between Modeling And Simulation vs Data Analyst?

AspectModeling And SimulationData Analyst
Required CredentialsBachelor's or higher in engineering, computer science, or related fields; often certifications in simulation softwareBachelor's in statistics, mathematics, or related fields; certifications in data analysis tools
Work EnvironmentResearch labs, engineering firms, government agenciesBusiness, finance, healthcare, or tech companies
Industry UsageEngineering, defense, aerospace, manufacturingFinance, marketing, healthcare, technology
Common Search & ComparisonModeling And Simulation vs Data Analyst

While both roles involve data and technical skills, Modeling And Simulation focuses on creating models to predict and analyze systems, often in engineering or scientific contexts. Data Analysts interpret data to inform business decisions. The roles share skills but differ in application and industry focus.

What are popular job titles related to Modeling And Simulation jobs in Massachusetts?

For Modeling And Simulation jobs in Massachusetts, the most frequently searched job titles are:

What job categories do people searching Modeling And Simulation jobs in Massachusetts look for?

The top searched job categories for Modeling And Simulation jobs in Massachusetts are:

What cities in Massachusetts are hiring for Modeling And Simulation jobs?

Cities in Massachusetts with the most Modeling And Simulation job openings:

Modeling And Simulation jobs near you
Infographic showing various Modeling And Simulation job openings in Massachusetts as of August 2026, with employment types broken down into 89% Full Time, 9% Part Time, and 2% Contract. Highlights an 82% Physical, 5% Hybrid, and 13% Remote job distribution, with an average salary of $110,583 per year, or $53.2 per hour.

Modeling & Simulations Director

Vrtx

Boston, MA • Hybrid

$194K - $291K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 2 days ago

New

Job description

Job Description

General Summary:

The Modeling & Simulations Associate Director will be responsible for developing and executing M&S strategies and activities in cross functional drug development project teams in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research and other colleagues within the R&D organization. This role determines, plans, and executes technically challenging analyses by using state of the art Modeling & Simulation methodologies to strongly contribute to critical decision making.

Key Duties and Responsibilities:

  • As Modeling & Simulations (M&S) lead in one or more cross functional drug development teams, responsibilities include the development and execution of Modeling & Simulation plans and analyses fully integrated with the overall development plans
  • By using state of the art Modeling & Simulation methodologies strongly contribute to critical decision making like study design, dose selection, probability of success estimation etc.
  • Independently perform mechanism based PKPD and population PK and PKPD-analyses, Clinical trial simulations and other model based analyses on a regular basis
  • Contribute to the continuous improvement in efficiency and effectiveness of our M&S capability by supporting training activities, evaluating and incorporating new M&S tools as appropriate.

Knowledge and Skills:

  • A specialized understanding of biology, pharmacokinetic and quantitative pharmacology (PKPD) principles.
  • Excellent hands-on skills in population PK and PKPD modeling, mechanistic PKPD modeling, Clinical trial simulations, Disease progression modeling, etc.
  • Excellent skills in the use of NonMem, PsN, R, Phoenix, and similar tools
  • Demonstrated strong leadership-, collaborative and influencing skills
  • Excellent, verbal and written communication skills
  • In-depth experience working in clinical development teams and integrating the use of PK/PD modeling and/or modeling of complex biological system

Education and Experience:

  • Master's or PhD, with preference in Pharmaceutical sciences, Pharmacometrics, mathematics, statistics, or other quantitative discipline with an emphasis on Pharmacometrics and PKPD modeling
  • Typically requires the following: PhD and 10 years or Master's Degree and 15 years experience in the application of pharmacometric and other modeling methodologies in the context of drug research & development in industry, academia or regulatory agencies

Pay Range:

$194,400 - $291,600

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Apply