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We are seeking a talented and highly motivated Senior Bioinformatics Scientist to support the development of Roche Diagnostics Molecular Assays that have a global impact on patient care. This role requires a broad understanding of assay development across diverse technologies, including NGS, Nanopore sequencing, and PCR. The successful candidate will collaborate closely with bioinformaticians, wet lab scientists, and external customers to design, implement, and maintain internal algorithms and tools for clinical diagnostic assay development.

The Opportunity:

• Collaborate with multidisciplinary teams of molecular and computational biologists, as well as wet lab scientists, to design, optimize, and troubleshoot advanced high-throughput sequencing assays and workflows for clinical diagnostic applications.

• Contribute bioinformatics expertise throughout the assay development lifecycle, including initial sequencing, validation, and production implementation, by developing and maintaining analytical tools and pipelines for processing diagnostic data from tumor, germline, and cell-free DNA samples.

• Create, implement, and streamline bioinformatics tools and workflows in partnership with wet lab scientists to enhance assay development efficiency and data quality.

• Provide hands-on troubleshooting to ensure data quality, integrity, and accessibility across the diagnostic workflow, while addressing the needs of internal and external stakeholders through scientific and business analyses.

• Advocate for best practices in documenting, training, and scaling algorithms, tools, and workflows to ensure reproducibility and scalability.

• Communicate project outcomes and team progress across various teams and organizational functions to promote alignment and collaboration.

Who You Are:

• Required: You have a Bachelor's Degree and 7+ years of experience

• Preferred: You have a PhD in Bioinformatics, Computational Biology, Statistics, or a related field with 2 years of industry experience in clinical diagnostics or related domain or a Masters degree in Bioinformatics, Computational Biology, Statistics, or a related field with 5 years of industry experience in clinical diagnostics or a related domain

• You have expertise in DNA/RNA sequencing data analysis and interpretation.

• You have a strong understanding of molecular biology principles and hands-on familiarity with next-generation sequencing laboratory processes.

Behaviors, competencies, and qualities of the ideal applicant.

• You are proficient in programming skills in R and/or Python, with experience working in a distributed Linux environment. (Proficiency in C++ or Java is a plus)

• You are proficient in creating clear, insightful visualizations of complex biological data, with strong presentation skills

• You are skilled in writing and maintaining bioinformatics workflows using workflow management systems such as Snakemake or Nextflow

• You have a solid understanding of cancer biology and in vitro diagnostics (IVD).

Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $ 102,100 - $167 7850. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let's build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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