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Manager Variant Scientist Jobs in California (NOW HIRING)

Natera

Associate Laboratory Director

San Carlos, CA · On-site

$128K - $167K/yr

Oversee the review of genetic and CNV variant data: interpret NGS and microarray results in the ... Analyze lab data, contribute to or write publications for high-quality scientific journals. * May ...

Natera

Associate Laboratory Director

San Carlos, CA · On-site

$128K - $167K/yr

Oversee the review of genetic and CNV variant data: interpret NGS and microarray results in the ... Manage a team: review and approve assigned work; mentor and develop personnel, including dedicated ...

Natera

Associate/Laboratory Director

San Carlos, CA

$128K - $167K/yr

Oversee the review of genetic and CNV variant data: interpret NGS results in the context of medical ... Analyze lab data, contribute to or write publications for high-quality scientific journals. * May ...

Integrated Resources INC

Packaging Technician

San Dimas, CA · On-site

$17 - $20.75/hr

Takes variant action only with approval of department management. * Receives well-defined ... IT Life Sciences Allied Healthcare CRO DIRECT # - (650)-399-0891 Gold Seal JCAHO Certified for ...

Natera

Associate/Laboratory Director

San Carlos, CA · On-site

$128K - $167K/yr

Oversee the review of genetic and CNV variant data: interpret NGS results in the context of medical ... Manage a team: review and approve assigned work; mentor and develop personnel, including dedicated ...

Integrated Resources INC

Packaging Technician

San Dimas, CA · On-site

$17 - $20.75/hr

Takes variant action only with approval of department management. Receives well-defined ... IT Life Sciences Allied Healthcare CRO Gold Seal JCAHO Certified for Health Care Staffing "INC 5 0 ...

Integrated Resources INC

Packaging Tech

San Dimas, CA · On-site

$17 - $20.75/hr

Takes variant action only with approval of department management. * Receives well-defined ... IT Life Sciences Allied Healthcare CRO DIRECT # - (732)-844-8715 Gold Seal JCAHO Certified for ...

Veracyte

Sr. Director, Lab Pipelines and LIMS

San Diego, CA · On-site

$112K - $147K/yr

... processing, variant calling, data transformation, and quality control. This role will be ... Manage roadmap planning, resource allocation, and execution across multiple teams and initiatives

Apptad, Inc.

Automation QA Engineer

San Diego, CA · On-site

Validate software behavior against genomic science concepts (e.g., sequencing data types, variant ... Test integrations with LIMS (Laboratory Information Management Systems), ensuring sample tracking ...

Adobe

Senior Growth Product Manager

San Jose, CA · On-site

$148K - $195K/yr

Use AI to speed up experiment ideation, hypothesis generation, copy/variant drafting, and analysis ... Finance & Data Science to quantify business impact What You Need to Succeed * 5+ years of Growth ...

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All JobsVariant Scientist JobsManager Variant Scientist JobsManager Variant Scientist Jobs in California

Manager Variant Scientist information

What is a manager variant scientist?

A Manager Variant Scientist is a professional who leads a team responsible for analyzing genetic variants, often within clinical or research laboratories. They oversee the interpretation of genomic data to identify mutations or variations relevant to patient care, disease research, or drug development. In addition to hands-on scientific analysis, they manage workflows, ensure data quality, and coordinate collaboration between scientists, clinicians, and other stakeholders. This role typically requires expertise in genetics, molecular biology, bioinformatics, and strong leadership skills.

What are the key skills and qualifications needed to thrive as a manager variant scientist?

To excel as a Manager Variant Scientist, you need a strong background in genetics, molecular biology, and bioinformatics, often supported by a PhD and relevant laboratory experience. Familiarity with genomic analysis tools, next-generation sequencing (NGS) platforms, and variant interpretation databases is typically required. Leadership, effective communication, and project management skills help in guiding teams and collaborating with cross-functional stakeholders. These competencies are vital for ensuring accurate variant analysis, driving scientific advancements, and successfully managing complex research projects.

What are some common challenges faced by a manager variant scientist when leading a genomics team?

A Manager Variant Scientist often encounters challenges such as balancing hands-on scientific analysis with leadership responsibilities, ensuring data accuracy and compliance with regulatory standards, and managing cross-functional communication between laboratory staff, bioinformaticians, and clinicians. Additionally, keeping up with rapid advancements in sequencing technologies and variant interpretation guidelines can be demanding. Effective managers foster a collaborative environment, provide mentorship, and prioritize continuous learning to overcome these challenges and maintain high-quality results.

What is the difference between Manager Variant Scientist vs Variant Scientist?

AspectManager Variant ScientistVariant Scientist
CredentialsBachelor's or Master's in Life Sciences, Biotech, or related fields; often with leadership experienceBachelor's or Master's in Life Sciences, Biotech, or related fields
Work EnvironmentLeads teams in R&D or manufacturing settings, overseeing variant developmentPerforms laboratory research, data analysis, and variant testing
Employer & Industry UsagePharmaceutical, biotech, or biotech manufacturing companiesResearch institutions, biotech firms, pharmaceutical companies

The main difference is that a Manager Variant Scientist oversees teams and projects, focusing on leadership and strategic planning, while a Variant Scientist primarily conducts laboratory research and data analysis. Both roles require similar technical credentials, but the managerial position adds responsibilities related to team management and project coordination.

What are the most commonly searched types of Variant Scientist jobs in California?

The most popular types of Variant Scientist jobs in California are:

What are popular job titles related to Manager Variant Scientist jobs in California?

For Manager Variant Scientist jobs in California, the most frequently searched job titles are:

What job categories do people searching Manager Variant Scientist jobs in California look for?

The top searched job categories for Manager Variant Scientist jobs in California are:

What cities in California are hiring for Manager Variant Scientist jobs?

Cities in California with the most Manager Variant Scientist job openings:

Manager Variant Scientist jobs near you
Infographic showing various Manager Variant Scientist job openings in California as of August 2026, with employment types broken down into 85% Full Time, 14% Part Time, and 1% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution.

Senior Laboratory Director, Oncology

BillionToOne

Menlo Park, CA • On-site

Full-time

Medical, Retirement, PTO

Posted 3 days ago

New

Job description

A Rare Opportunity to Shape the Future of Genomics
Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.
Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.
If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.
BillionToOne is seeking a Senior Laboratory Director, Oncology to lead and own the daily operations of our high-complexity oncology clinical laboratory. Reporting to the SVP of Laboratory Operations, this person owns oncology laboratory operations end to end, with accountability for quality, turnaround time, capacity, cost, and regulatory compliance. This is a full-time, onsite role (2 to 3 days/week) in Menlo Park, CA.
Responsibilities:
  • Lead, build, and scale the oncology laboratory organization (technologists, supervisors, and operations managers), including headcount planning, hiring, and competency management.
  • Own the oncology laboratory operating budget and P&L, including COGS, operating expenses, and capital equipment planning.
  • Drive operational performance against turnaround-time (TAT), throughput, capacity, and quality targets; implement process improvements and automation to scale.
  • Lead laboratory scale-up, new-assay and instrument onboarding, inspection readiness, and vendor and capital procurement.
  • Provide technical oversight of somatic variant interpretation and oncology report sign-out from Northstar liquid biopsy assays, ensuring accuracy and timeliness.
  • Troubleshoot technical issues across oncology workflows (liquid biopsy sample prep, NGS library preparation, sequencing, and data analysis).
  • Ensure compliance with CLIA, CAP, and NYSDOH standards; oversee Non-Conforming Events, CAPAs, and documentation of SOPs, validations, QC records, competencies, proficiency testing, and report archives.
  • Collaborate with bioinformatics, R&D, and medical affairs on assay development and interpretation guidelines; serve as a subject-matter expert on oncology variant interpretation (AMP/CAP/NYS guidelines).

Qualifications:
  • Doctoral degree (PhD, MD, or equivalent) in genetics, molecular biology, or a related field, with board certification (ABMGG, ABP in Molecular Genetic Pathology, or equivalent).
  • Valid or eligible for California Clinical Laboratory Director license (CGMB, CGMBS, MD/DO licensure) and New York State CoQ in oncology testing.
  • 7+ years in a regulated clinical laboratory environment (CLIA/CAP/NYSDOH), with at least 4 years in molecular oncology testing including NGS.
  • Proven leadership developing, validating, and implementing oncology assays (e.g., somatic mutation panels, methylation), with deep knowledge of cancer genomics (tumor heterogeneity, somatic driver mutations, targeted therapies).
  • Experience with variant interpretation databases (COSMIC, OncoKB, ClinVar), IGV and BAM file review, and molecular tumor boards; proficiency with LIMS and oncology bioinformatics tools.
  • Strong analytical, communication, and organizational skills, with a track record of leading teams in high-growth environments.

Benefits And Perks:
  • Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousands patients
  • Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
  • Extremely generous Family Bonding Leave for eligible employees (16 weeks, paid at 100%)
  • Supplemental fertility benefits coverage
  • Retirement savings program including a 4% Company match
  • Increase paid time off with increased tenure
  • Latest and greatest hardware (laptop, lab equipment, facilities)
  • Daily on-site lunches provided from top eateries
  • A variety of perks on campus (state of the art gym, restaurant)
  • Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).
For this position, we offer a total compensation package of $471,554 per year, including a base pay range of $246,525 - $267,962 per year.
BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
For more information about how we protect your information, we encourage you to review our Privacy Policy.
BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.
Our Impact
Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.
Unity Confirm™ enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne's Fetal Cell Capture™ Technology.
Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.
Our Growth
From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.
Our Recognition
Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.
Our Future
Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.
Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com

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