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Lupus Research Jobs (NOW HIRING)

The University of Texas Southwestern Medical Center

Our research combines functional immunology with genomic and epigenomic approaches to uncover the mechanisms that drive systemic lupus erythematosus and other immune-mediated diseases. The successful ...

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How much do lupus research jobs pay per hour?

As of Sep 14, 2026, the average hourly pay for lupus research in the United States is $45.84, according to ZipRecruiter salary data. Most workers in this role earn between $37.26 and $55.05 per hour, depending on experience, location, and employer.

What is lupus research?

Lupus research is the scientific study focused on understanding lupus, a chronic autoimmune disease that can affect various parts of the body. Researchers investigate the causes, risk factors, symptoms, and treatments for lupus to improve patient outcomes. This research often involves clinical trials, laboratory studies, and observational studies. The ultimate goal is to develop better diagnostic tools, more effective treatments, and eventually a cure for lupus.

What are the key skills and qualifications needed to thrive as a lupus researcher?

To thrive as a Lupus Researcher, you need a strong background in biomedical sciences, clinical research methodologies, and data analysis, typically supported by an advanced degree (PhD, MD, or equivalent). Familiarity with laboratory technologies, statistical software (such as SPSS or R), and compliance with research ethics and clinical trial regulations is essential. Critical thinking, collaboration, and effective communication are vital soft skills for advancing research and sharing findings. These skills ensure the production of high-quality, ethical research that can lead to better diagnostics, treatments, and ultimately improved outcomes for lupus patients.

What are the most common challenges faced by professionals working in lupus research, and how can new team members prepare for them?

Professionals in lupus research often encounter challenges such as recruiting and retaining diverse patient populations for clinical trials, managing complex data sets, and staying current with rapid developments in autoimmune research. New team members can prepare by familiarizing themselves with clinical trial protocols, building strong communication skills for interdisciplinary collaboration, and engaging with patient advocacy groups to better understand patient perspectives. Being adaptable and proactive in learning about new research methodologies will also help overcome the dynamic nature of this field.

What is the difference between Lupus Research vs Rheumatology Research?

AspectLupus ResearchRheumatology Research
Required CredentialsMedical or scientific degrees, research certificationsMedical or scientific degrees, research certifications
Work EnvironmentLaboratories, research institutions, hospitalsLaboratories, research institutions, hospitals
Industry UsageFocuses specifically on lupus and autoimmune diseasesBroader focus on various rheumatic diseases including lupus

While Lupus Research concentrates specifically on studying and understanding lupus, Rheumatology Research covers a wider range of rheumatic diseases, including lupus. Both roles require similar credentials and often share work environments, but their focus areas differ, with Lupus Research dedicated solely to lupus-related studies.

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Lupus Research jobs near you
Infographic showing various Lupus Research job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 87% Full Time, 10% Part Time, and 1% Contract. Highlights an 76% Physical, 4% Hybrid, and 20% Remote job distribution, with an average salary of $95,345 per year, or $45.8 per hour.

Postdoctoral Scientist/Assistant Staff Scientist - Nath Lab

Oklahoma City, OK • On-site

Oklahoma Medical Research Foundation
Scientific Research and Development Services • 201 - 500 employees
Learn more about Oklahoma Medical Research Foundationexternal

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 22 days ago

Job description

Molecular Immunology and Functional Genomics of Lupus
The Nath Lab at the Oklahoma Medical Research Foundation (OMRF) seeks an outstanding Postdoctoral Scientist or Assistant Staff Scientist to join our multidisciplinary research team investigating the molecular mechanisms through which non-coding genetic variants identified by genome-wide association studies (GWAS) contribute to Systemic Lupus Erythematosus (SLE) and other autoimmune diseases.

This position is ideal for a highly motivated molecular biologist with strong expertise in immunology who is interested in applying cutting-edge genomic technologies and artificial intelligence to elucidate the functional consequences of disease-associated genetic variation.

Research Program
Genome-wide association studies have identified hundreds of genetic loci associated with SLE and other autoimmune diseases, and the vast majority of risk variants are located in non-coding regions of the genome. The central challenge is determining how these variants influence gene regulation and immune cell function.

Our laboratory integrates computational genomics, molecular biology, functional genomics, and immunology to elucidate the molecular mechanisms underlying disease-associated variants. We investigate multiple regulatory mechanisms, including: enhancer and promoter activity, alternative RNA splicing (sQTLs), gene expression regulation (eQTLs), chromatin accessibility and epigenetic regulation, and three-dimensional chromatin interactions.

Responsibilities
The successful candidate will:

  • Functionally characterize non-coding GWAS variants associated with SLE and related autoimmune diseases.
  • Design and perform molecular biology experiments to determine how regulatory variants alter gene function.
  • Perform assays including:
    • Reporter gene (luciferase) assays
    • Minigene splicing assays
    • CRISPR/Cas9 genome editing (knockout, knock-in, CRISPRi, CRISPRa)
    • Gene expression analyses (RT-qPCR, RNA-seq)
    • Protein expression analyses (Western blot)
    • Chromatin and regulatory assays
  • Culture and manipulate human immune cell lines and primary immune cells.
  • Perform immunological assays including flow cytometry, T-cell activation, cytokine profiling, proliferation, apoptosis, and related functional studies.
  • Collaborate with computational biologists to integrate GWAS, functional genomics, and AI-based genomic predictions.
  • Analyze experimental data and contribute to publications and grant applications.

Minimum Qualifications

  • Ph.D. in a biological science, chemistry, physics or other relevant area, M.D., or equivalent.

The successful candidate should demonstrate:

  • Strong experimental skills in molecular biology
  • Excellent written and verbal communication skills
  • Ability to work independently and collaboratively
  • Strong publication record appropriate for career stage

Preferred Qualifications

Applicants should have expertise in several of the following areas:

  • Molecular biology
  • Immunology
  • Functional genomics
  • Human genetics
  • CRISPR genome editing
  • Cell culture of mammalian and immune cells
  • RNA biology and gene regulation
  • Flow cytometry
  • Next-generation sequencing
  • Bioinformatics or computational biology (preferred but not required)

Programming experience in R or Python is advantageous.

OMRF Overview
Founded in 1946, the Oklahoma Medical Research Foundation (OMRF) is among the nation’s oldest, most respected independent, nonprofit biomedical research institutes. OMRF is dedicated to understanding and developing more effective treatments for human diseases, focusing on critical research areas such as Alzheimer’s disease, cancer, lupus, multiple sclerosis, and cardiovascular disease. OMRF follows an innovative cross-disciplinary approach to medical research and ranks among the nation’s leaders in patents per scientist.

Located in Oklahoma City, a city that offers a dynamic and flourishing downtown area, with low cost of living, short commute times and a diversified economy, OMRF has been voted one of the Top Workplaces since the inception of the award. This achievement has been accomplished thanks to OMRF individuals who share a unified understanding that our excellence can only be fully realized with a collective commitment to our mission, “. . . so that more may live longer, healthier lives.” Successful candidates will demonstrate commitment to this mission.

OMRF Benefits
We offer competitive salaries and comprehensive benefits to full-time employees including medical, dental, and vision insurance, minimum 8% company retirement contribution, vacation and sick leave, and paid holidays. All employees have access to our onsite café, free onsite fitness center with access to personal trainer, free parking and much more! Relocation assistance available for those located 50 miles outside of Oklahoma City metro. Learn more about our benefits here.

OMRF is an Equal Opportunity Employer.