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Lead Computational Scientist Jobs (NOW HIRING)

MIT Human Resources

Research Scientist 1

Cambridge, MA · On-site

RESEARCH SCIENTIST 1 , Computer Science and Artificial Intelligence Lab, will lead computational analyses of large-scale single-cell and spatial multi-omic datasets derived from human postmortem ...

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How much do lead computational scientist jobs pay per year?

As of Sep 11, 2026, the average yearly pay for lead computational scientist in the United States is $112,722.00, according to ZipRecruiter salary data. Most workers in this role earn between $83,500.00 and $123,000.00 per year, depending on experience, location, and employer.

What is a lead computational scientist?

Lead Computational Scientists are experts who oversee complex computational projects, often within scientific or research-driven organizations. They are responsible for developing and implementing advanced algorithms, managing large datasets, and guiding teams of other scientists or engineers. Their work often involves collaborating with cross-disciplinary teams to solve challenging scientific problems using computational methods. In addition, they play a key role in setting research directions, mentoring junior staff, and ensuring the technical quality of project deliverables.

What skills and qualifications are needed to be a lead computational scientist?

To thrive as a Lead Computational Scientist, you need advanced expertise in computational modeling, data analysis, and a PhD or equivalent experience in a quantitative science. Familiarity with programming languages (such as Python or R), high-performance computing environments, and specialized software tools is typically required. Leadership, problem-solving, and effective communication are essential soft skills for managing teams and collaborating across disciplines. These skills enable effective project delivery, foster innovation, and ensure that complex scientific problems are solved efficiently.

How does a lead computational scientist collaborate with cross-functional teams in a research organization?

A Lead Computational Scientist often works closely with experimental scientists, data engineers, and software developers to design and implement computational solutions for complex research problems. They act as a bridge between computational methods and practical applications, ensuring models and simulations align with project goals. Regular meetings, code reviews, and interdisciplinary brainstorming sessions are common, fostering an environment of knowledge sharing and innovation. Effective communication and adaptability are key, as priorities can shift based on evolving research directions.

What cities are hiring for Lead Computational Scientist jobs?

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Infographic showing various Lead Computational Scientist job openings in the United States as of August 2026, with employment types broken down into 87% Full Time, 10% Part Time, and 3% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $112,722 per year, or $54.2 per hour.

Lead Scientist / Associate Director, Bioinformatics and Data Science

Emeryville, CA • On-site, Remote

Profluent
See more jobs at Profluentexternal

$205K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 29 days ago

Job description

Profluent is the frontier AI lab for biology. Profluent builds powerful foundation models for all of life's molecules, unlocking solutions that transform medicine, agriculture, and beyond. Founded in 2022 and headquartered in Emeryville, CA, Profluent is backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures and has raised over $150M to date.
We're seeking an experienced computational scientist to lead the design, development, and operation of the NGS analysis platform that powers Profluent's gene editing, protein design, and therapeutic programs. You'll work at the intersection of computational biology, software engineering, and experimental biology to build scalable systems that extract clear, actionable insights from large-scale sequencing data.
This is a high-impact leadership role at the intersection of computational biology, experimental science, and software engineering. You'll define how Profluent characterizes the activity and specificity of novel gene editors, establish rigorous and reproducible practices across bioinformatics and data science, and mentor and grow a team as our platform and therapeutic programs scale.
Responsibilities
  • Lead the development and operation of Profluent's NGS analysis platform for gene editing, protein design, and therapeutic programs
  • Develop scalable pipelines and analytical methods for new sequencing assays
  • Partner with wet-lab teams to design, test, troubleshoot, and validate new assays
  • Lead computational characterization of gene-editor on-target activity, specificity, and off-target effects
  • Translate sequencing data into clear biological insights, program decisions, and regulatory-ready analyses
  • Collaborate with computational teams to curate high-quality datasets for model training and evaluation
  • Establish rigorous, reproducible practices for analytical validation, testing, documentation, and code review
  • Recruit, mentor, and develop a high-performing bioinformatics and data science team

Qualifications
  • PhD or MS in Bioinformatics, Computational Biology, Computer Science, or a related quantitative field
  • PhD with 5+ years or MS with 7+ years of industry experience applying NGS and computational analysis to gene or cell therapy development
  • Deep expertise in the design, analysis, and interpretation of high-throughput sequencing assays
  • Strong programming and quantitative analysis skills, particularly in Python
  • Proven ability to translate complex sequencing data into clear biological insights and program decisions
  • Experience partnering closely with experimental scientists to guide assay design, troubleshoot results, and define follow-up studies
  • Demonstrated scientific leadership, including setting analytical strategy, leading complex cross-functional projects, and mentoring computational scientists
  • Experience developing scalable, reproducible, and well-validated computational workflows

Preferences
  • Experience with CRISPR-based gene editing data and analysis
  • Familiarity with SQL and data modeling for biological or experimental data
  • Experience with LIMS platforms (e.g., Benchling) and lab data integration
  • Track record of developing production-quality scientific software and tools

What We Offer
  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.
Work Authorization Requirement
Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.
Employment Eligibility Verification
Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.
TO ALL RECRUITMENT AGENCIES:
Profluent does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Profluent is not responsible for any fees related to unsolicited resumes.
Hiring Salary Range
$205,379-$245,632 USD

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