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Lcms Jobs in Madison, WI (NOW HIRING)

Labcorp

Method Validation Scientist - II LC-MS

Madison, WI · On-site

  • Medical

  • Dental

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  • PTO

Monday - Friday (Day Shift) Method Validation Scientist II - LCMS Job Responsibilities: * Organize and perform routine to moderate level of method validation/testing (and all associated activities ...

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How much do lcms jobs pay per year?

As of Aug 15, 2026, the average yearly pay for lcms in Madison, WI is $213,552.00, according to ZipRecruiter salary data. Most workers in this role earn between $206,600.00 and $221,700.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an LCMS specialist?

To thrive as an LCMS Specialist, you need a solid background in analytical chemistry, laboratory techniques, and a relevant scientific degree such as chemistry, biochemistry, or a related field. Expertise in operating and troubleshooting LCMS instruments, data analysis software (like MassLynx or Xcalibur), and understanding of regulatory standards is typically required. Attention to detail, problem-solving abilities, and strong communication skills are crucial soft skills in this role. These competencies are essential for ensuring accurate data generation, maintaining instrument performance, and supporting research or quality control objectives.

What are LCMS jobs?

LCMS jobs refer to positions that involve working with Liquid Chromatography-Mass Spectrometry (LC-MS) technology, which is commonly used in analytical chemistry for identifying and quantifying compounds in complex mixtures. Professionals in these roles may operate LC-MS instruments, develop analytical methods, analyze data, and support research or quality control in fields such as pharmaceuticals, environmental science, and food testing. Typical job titles include LCMS Analyst, Scientist, or Technician, and they often require a background in chemistry, biochemistry, or a related field.

What are LCMS jobs?

Liquid chromatography–mass spectrometry (LC-MS or LCMS) is the term for an analytical chemistry technique. Scientists use LC-MS to separate, isolate, and evaluate components of a compound. The duties of people in LC-MS jobs involve using instruments to perform analysis in a laboratory setting. Researchers, R&D scientists, and laboratory technicians use LC-MS techniques to test products in the food, cosmetic, and pharmaceutical industries. Scientists with chemical, agricultural, and biomedical qualifications also use this technique. After collecting data from the LC-MS equipment, your responsibilities include using your scientific skills to interpret your findings and, in some cases, apply the results to product development.

What are some common challenges faced by LCMS analysts and how can they be addressed?

LCMS analysts often encounter challenges such as troubleshooting instrument malfunctions, managing complex sample matrices, and ensuring accurate calibration and maintenance of equipment. Staying current with evolving analytical methods and software updates is essential. Proactively documenting procedures, participating in regular training, and collaborating closely with colleagues in quality control or research teams can help address these challenges and maintain high-quality analytical results.

What is the difference between Lcms vs Laboratory Technician?

AspectLcmsLaboratory Technician
Required CredentialsDegree in Chemistry, Biochemistry, or related field; certification often preferredHigh school diploma or associate degree; technical training
Work EnvironmentAnalytical labs, research facilities, pharmaceutical or environmental labsClinical, industrial, or research laboratories
Job FocusOperating and maintaining liquid chromatography-mass spectrometry equipment, data analysisSample preparation, testing, data recording, basic instrument operation

LCMS specialists focus on operating advanced analytical instruments like liquid chromatography-mass spectrometry, requiring specialized training and certifications. Laboratory Technicians perform broader testing tasks, often with less specialized equipment. While both roles work in laboratory settings, LCMS roles demand more technical expertise in analytical instrumentation, making them more specialized within the lab environment.

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Infographic showing various Lcms job openings in Madison, WI as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $213,552 per year, or $102.7 per hour.

Scientist I, Quality Control (2nd Shift)

Arrowhead Pharmaceuticals

Madison, WI

$90K - $108K/yr

Full-time, Other

Posted 11 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a Scientist I, Quality Control to join our growing Quality organization in Verona, Wisconsin. In this role, you will support analytical method validation, method transfer, and quality control testing for pharmaceutical raw materials, in-process manufacturing samples, drug substance, drug product, and stability studies across our innovative RNAi therapeutic pipeline.

This position offers the opportunity to work in a fast-paced GMP laboratory, applying advanced analytical techniques while collaborating closely with Analytical Development and Manufacturing. You'll serve as a technical resource within the laboratory, contribute to scientific problem-solving, and help ensure the quality and integrity of products advancing through development and commercialization.

This role is 2nd shift and eligible for a 10% shift differential.

Responsibilities

  • Perform analytical testing of raw materials, in-process samples, drug substances, drug products, and stability samples using validated analytical methods.
  • Execute method validation, method transfer, and routine QC testing activities in accordance with cGMP requirements and ICH guidelines.
  • Operate, troubleshoot, and interpret data from analytical instrumentation, including
    • LC-MS
    • HPLC/UHPLC (RP and AEX)
    • Gas Chromatography (GC)
    • Karl Fischer titration
    • FTIR
    • Endotoxin/LAL testing
    • Raman spectroscopy
  • Analyze and interpret analytical data, including stability trends and degradation profiles.
  • Independently investigate analytical results and make sound scientific decisions while ensuring data quality and compliance.
  • Collaborate cross-functionally with Analytical Development, Manufacturing, and Quality teams to support product development and manufacturing activities.
  • Lead technical discussions, troubleshoot analytical challenges, and contribute to continuous process improvements.
  • Train and mentor laboratory colleagues on analytical techniques, instrumentation, and laboratory best practices.
  • Maintain accurate documentation in compliance with cGMP, Good Documentation Practices (GDP), and internal procedures.
  • Support laboratory investigations, method improvements, and other Quality Control initiatives as needed.

Requirements

  • Bachelor's degree in Chemistry or a related scientific discipline with 5+ years of relevant laboratory experience, or Master's degree in Chemistry or a related scientific discipline with 3+ years of relevant laboratory experience.
  • Fully knowledgeable of cGMP and ICH laboratory requirements and operations.
  • Strong attention to detail and good documentation practices; comfort working against defined hold times and turnaround targets.
  • Prior experience testing oligonucleotides, peptides, or other synthetic biomolecules.
  • Hands-on experience with LCMS, AEX-HPLC, RP-HPLC/UHPLC, Karl Fischer titration, or LAL/endotoxin testing.
  • Experience supporting in-process (real-time) testing in a manufacturing-adjacent QC lab.
  • Fully knowledgeable of cGMP and ICH laboratory requirements and operations.
  • Proficient and demonstrated experience with analytical instrumentation, test methodology/validations/transfers, data acquisition systems, and typical cGMP policies/practices.
Wisconsin pay range
$90,000—$108,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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