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Title: Post Doctoral Research Associate - Dr. Rachid Skouta Lab

Executive Area: Academic Affairs

College/School/MBU: College of Natural Sciences

Department: Biology

Work Location: Amherst

Schedule:Full time

Work Arrangement:Onsite

Job Summary

The Skouta research group covers chemical biology, and in vivo studies. The major interest of the lab is the development of small molecule inducers of ferroptosis cell death with well-defined target(s) for cancer therapeutics. Ferroptosis is a recently emerged novel cell death that may complement the known programmed cell death (PMID: 27159577; PMID: 24592866; PMID: 35453641).
We are currently seeking a highly skilled and dedicated individual to join our research team focused on studying the toxicity and efficacy of small molecules in vivo. As a member of our team, you will play a critical role in evaluating the safety and effectiveness of novel compounds for potential therapeutic applications. The successful candidate will be involved in the evaluation of the efficacy study of small molecules inducing ferroptosis in mice for the development of better therapeutic treatments. The appointee is expected to establish some independence in research design and execution, and to publish the lab work as appropriate in collaboration with the principal investigator.

Essential Functions

In Vivo Study Design: Proficiency in designing and planning in vivo studies, including dose selection, route of administration, and appropriate animal models.
Animal Handling and Care: Experience in handling and caring for laboratory animals, including proper animal welfare practices, dosing techniques, and sample collection procedures.
Toxicology Assessment: Understanding of toxicology study design and execution, including acute, subchronic, and chronic toxicity studies, as well as assessment of organ toxicity, immunotoxicity, genotoxicity, and carcinogenicity.
Biomarker Analysis: Proficiency in analyzing biomarkers to assess the efficacy and safety of small molecules, including the use of various assays, immunoassays, and molecular techniques.
Cell Culture: Experience in maintaining and culturing mammalian cells, including cell line generation, transfection, and cell-based assays for assessing the effects of small molecules on cellular processes.
Western Blotting (WB): Strong expertise in performing Western blot experiments, including protein gel electrophoresis, transfer, blocking, antibody incubation, detection, and quantification.
Protein Extraction and Purification: Knowledge of protein extraction techniques from various samples, such as cells or tissues, and proficiency in protein purification methods, such as affinity chromatography or immunoprecipitation.
Study Monitoring and Data Collection: Experience in monitoring studies, collecting and managing data, maintaining accurate records, and ensuring compliance with regulatory requirements.
Data Analysis and Interpretation: Strong analytical skills to analyze and interpret data generated from in vivo studies, including statistical analysis, dose-response relationships, and correlation analysis.
Regulatory Compliance: Knowledge of regulatory guidelines and requirements for conducting in vivo studies, including Good Laboratory Practices (GLP) and Institutional Animal Care and Use Committee (IACUC) regulations.
Scientific Communication: Excellent written and verbal communication skills to document and present study findings, prepare reports, and contribute to scientific publications.

Other Functions

Work collaboratively and effectively to promote teamwork, equality and inclusiveness.
Work in partnership with colleagues within the CNS community and across the campus to support the Dean's strategic priorities.
Perform other duties as assigned in support of the mission and goals of the College of Natural Sciences.

Minimum Qualifications

The successful candidate must have a PhD in Biology or a related field before start date of appointment.
At least three (3) years of lab experience working with mice models is required.

Preferred Qualifications

Highly motivated and experienced researcher with a strong background in studying the toxicity and efficacy of small molecules in vivo.

Additional Details

At UMass Amherst and in CNS, we strive to be a community where every individual feels a sense of belonging, where every individual is included, and where every individual is valued. These values and goals are reflected in the College of Natural Sciences' Inclusive Excellence framework and in the UMass Amherst's For the Common Good: 2024-2034 Strategic Plan.

Working Conditions

Work is performed in a laboratory or healthcare setting and may involve exposure to chemicals or infectious diseases. Requires standing for extended periods of time and/or use of protective gear.

Work Schedule and Work Arrangement

Full time position 40 hours a week, Monday - Friday, flexible hours.
Some nights and weekends required.

Salary Information

Salary minimum is determined by collective bargaining agreement based on years of experience. Salary may exceed the floor and will be determined by the PI (final salary will be stated in offer letter).
Current floors based on 100% time, 40 hours/week:
0-2 years $62,838
3-4 years $66,287
5+ years $71,033

Special Instructions for Applicants

Along with the application, please submit a resume. References will be checked at the finalist stage. Please be prepared to provide contact information for three (3) professional references.

This position will remain open for the time period required by any applicable collective bargaining agreement and will continue until a suitable candidate pool is identified. Interested applicants are strongly encouraged to apply early.