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Junior Computational Structural Biology Jobs (NOW HIRING)

Battelle

Computational Biologist

Columbus, OH · On-site

S. plus 10 years of experience in biochemistry, biophysics, computational biology, structural biology, or a closely related field * Deep expertise in computational protein engineering, including AI ...

Astera

Scientist - Computational Biophysics

Emeryville, CA · On-site

$100K - $180K/yr

... computational models, and global infrastructure needed to capture molecular motion at scale ... Our goal is to establish dynamic structural biology as a foundational pillar of modern science, as ...

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How much do junior computational structural biology jobs pay per hour?

As of Aug 10, 2026, the average hourly pay for junior computational structural biology in the United States is $26.96, according to ZipRecruiter salary data. Most workers in this role earn between $16.35 and $33.17 per hour, depending on experience, location, and employer.

What is the difference between Junior Computational Structural Biology vs Junior Bioinformatics Analyst?

AspectJunior Computational Structural BiologyJunior Bioinformatics Analyst
Required CredentialsBachelor's or Master's in Bioinformatics, Computational Biology, or related fieldsBachelor's or Master's in Bioinformatics, Computer Science, or related fields
Work EnvironmentResearch labs, biotech companies, academic institutionsResearch institutions, healthcare, biotech firms
Industry UsageStructural modeling, molecular dynamics, protein analysisGenomic data analysis, data management, software development
Common Search/ComparisonYesYes

Junior Computational Structural Biology focuses on analyzing and modeling the 3D structures of biological molecules, often requiring skills in structural bioinformatics and molecular simulations. In contrast, Junior Bioinformatics Analysts typically handle large-scale genomic or proteomic data, emphasizing data analysis and software tools. Both roles share foundational bioinformatics skills but differ in their specific focus areas and applications.

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Junior Computational Structural Biology jobs near you
Infographic showing various Junior Computational Structural Biology job openings in the United States as of August 2026, with employment types broken down into 91% Full Time, 5% Part Time, 3% Contract, and 1% Nights. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $56,068 per year, or $27 per hour.

Principal Scientist, Structural Biology

Novartis Farmacéutica

San Diego, CA • On-site

$108.50 - $222.30/hr

Other

Medical, Life, Retirement, PTO

Posted 27 days ago

Job description

Job Title

Principal Scientist – Structural Biology (onsite, San Diego, CA)

Overview

At Novartis, the Protein Sciences group plays a pivotal role in advancing early‑stage drug discovery by enabling deep structural and functional insights into therapeutic targets. Structural Biology is a cornerstone capability, enabling structure‑guided drug discovery for some of the most challenging and high‑impact targets in medicine. This is a unique opportunity to join a world‑class structural biology team within one of the largest and most innovative pharmaceutical companies, with access to state‑of‑the‑art instrumentation and a collaborative environment that empowers meaningful contributions to the discovery and development of life‑changing medicines.

Key Responsibilities
  • Lead and execute protein production and X‑ray crystallography to elucidate protein‑small molecule, protein‑peptide, and/or protein‑protein interactions, supporting drug discovery initiatives.
  • Successfully drive gene‑to‑structure small molecule drug discovery projects.
  • Leverage expertise in protein production and structural biology to characterize structure‑function relationships, investigate novel mechanisms of action, and address complex scientific questions.
  • Collaborate with cross‑functional teams, including protein scientists, biophysicists, chemists, and computational modelers, to facilitate structure‑based drug design.
  • Advance initiatives and drug discovery programs by leveraging innovative approaches, such as AI applications.
Essential Requirements
  • Ph.D. in structural biology, biophysics, biochemistry, or a related field with over 5 years of relevant experience in X‑ray crystallography within either industrial or academic settings.
  • Demonstrated expertise in protein expression across E. coli, insect, and mammalian expression systems, and extensive experience in protein purification and characterization.
  • Proven track record in application of X‑ray crystallography to characterize protein‑ligand and protein‑protein complexes, including crystallization screening, optimization, data processing, structure refinement, and analysis.
  • Outstanding communication skills and strong ability to collaborate within multidisciplinary teams in a fast‑paced, goal‑driven environment.
Desirable Requirements
  • Understanding of AI/ML tools for structural biology.
  • Experience with biochemical assays and biophysical methods.
  • Experience with Cryo‑EM is a plus.
Compensation and Benefits

Salary ranges:
Principal Scientist I: $108,500 – $201,500 per year
Principal Scientist II: $119,700 – $222,300 per year

Final salary offered is determined based on factors such as relevant skills and experience. The offer will be reviewed periodically. The compensation package includes a performance‑based cash incentive and, depending on the level of the role, eligibility for annual equity awards. US‑based employees receive a comprehensive benefits package covering health, life and disability benefits, a 401(k) with company contribution and match, and a generous time‑off package that includes vacation, personal days, holidays and other leaves.

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