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Monday Wednesday Friday Computational Structural Biology Jobs

Guidehouse

Biologist

Bethesda, MD · On-site

$85K - $141K/yr

D. in Structural Biology, Biochemistry, Biophysics, Computational Biology, or a closely related biomedical field; OR Master's degree with a minimum of FOUR (4) years of experience in structural ...

Guidehouse

Biologist

Bethesda, MD · On-site

$85K - $141K/yr

D. in Structural Biology, Biochemistry, Biophysics, Computational Biology, or a closely related biomedical field; OR Master's degree with a minimum of FOUR (4) years of experience in structural ...

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As of Aug 16, 2026, the average hourly pay for monday wednesday friday computational structural biology in the United States is $23.42, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $25.72 per hour, depending on experience, location, and employer.

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Computational Biologics Design

AstraZeneca

Gaithersburg, MD • On-site

Full-time

Posted 20 days ago

AstraZeneca rating

8.4

Company rating: 8.4 out of 10

Based on 45 frontline employees who took The Breakroom Quiz

22nd of 86 rated pharmaceutical

Job description

Job Description

Role Description

Do you have expertise in, and passion for data science and AI? Would you like to play a pivotal role that impacts the delivery of novel biologics drugs for oncology, respiratory and cardiovascular diseases in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be for you!

The Biologics Engineering team is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts.

Central to this effort are the Biologics Augmented Biologics Design team who are building on existing technologies to advance learning from the large and complex data sets we generate and excitingly the team is growing to meet this challenge. This role provides the opportunity for a talented and motivated computational structural biologist.

Typical Accountabilities

  • Lead the in silico support on pipeline therapeutic projects in collaboration with AZ stakeholders

  • Work collaboratively with data and drug discovery scientists to establish structural analytics workflows for biologics discovery

  • Contribute to the development of an end-to-end data analysis capability within Biologics Engineering team as part of a cross-functional team

  • Drive innovative structural, generative & machine learning methods for the design and optimisation of biologic therapeutics

  • Participate in strategic external collaborations

  • Demonstrate effective communication to translate complex concepts to non-experts in internal and external scientific meetings

Must Have

PhD in relevant field (e.g. Structural Biology, Computer Science, Bioinformatics, Physics and Mathematics)and 2 years experience in Silico Design
Knowledge of computational structural biology and demonstrated application of data analysis methods
Experience with structural modelling platforms (e.g. Schrodinger, Rosetta etc)
Familiarity with antibody discovery & optimisation, protein structures
Skilled in applying generative AI, Machine learning or deep learning to design and optimise proteins
Strong, professional communication skills and excellent attention to detail, capable of developing good working relationships with diverse individuals
Experience working within a team environment
Acts with integrity and does the right thing

Desireable

  • Knowledge of FAIR data principles

  • Experience with the analysis of large structural, sequence and experimental datasets.

Date Posted

27-Jul-2026

Closing Date

20-Aug-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

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