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Internship Downstream Process Development Jobs in California

Debut Biotech

Staff Process Engineer

San Diego, CA

Staff Process Engineer Summary The Staff Process Engineer, Downstream Processing (DSP) will take a leading role in the strategy, development, and execution of downstream purification processes for ...

Debut Biotech

Staff Process Engineer

San Diego, CA · On-site

Staff Process Engineer Summary The Staff Process Engineer, Downstream Processing (DSP) will take a leading role in the strategy, development, and execution of downstream purification processes for ...

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Internship Downstream Process Development information

What is an internship in downstream process development?

An Internship in Downstream Process Development is a temporary position, typically for students or recent graduates, focused on learning and supporting the processes involved in purifying and formulating biopharmaceutical products after the initial production stage. Interns in this field gain hands-on experience with techniques such as filtration, chromatography, and quality control, and often work within a research and development or manufacturing environment. This internship helps build skills in laboratory methods, data analysis, and process optimization, making it valuable for those interested in careers in biotechnology or pharmaceuticals.

What types of hands-on projects can I expect to work on during an internship in downstream process development?

As an intern in Downstream Process Development, you will typically assist with projects focused on purification and recovery of biological products, such as proteins or antibodies, from complex mixtures. This often includes tasks like preparing chromatography columns, performing filtration techniques, and conducting sample analysis using methods such as SDS-PAGE or HPLC. You’ll also collaborate closely with experienced scientists and engineers, participate in team meetings to review data, and help troubleshoot process challenges. These experiences provide valuable insight into both laboratory workflows and the broader bioprocess development pipeline.

What are the key skills and qualifications needed to thrive as an internship in downstream process development, and why are they important?

To thrive in an Internship Downstream Process Development role, a solid background in biotechnology, chemical engineering, or a related field, along with foundational lab skills, is essential. Familiarity with bioprocessing techniques, analytical instruments, and data analysis software is typically required, and experience with GMP environments can be advantageous. Strong problem-solving abilities, attention to detail, and effective communication are important soft skills for collaborating with team members and documenting results. These competencies ensure interns can contribute to optimizing purification processes and maintaining high standards in biopharmaceutical development.

What is the difference between Internship Downstream Process Development vs Downstream Process Technician?

AspectInternship Downstream Process DevelopmentDownstream Process Technician
CredentialsTypically pursuing or holding a degree in biotech, chemistry, or related fieldsUsually requires technical diploma or associate degree in biotech or related areas
Work EnvironmentLaboratory and development settings, focusing on process optimization and experimental workManufacturing floor, operating equipment, and performing process runs
ResponsibilitiesAssisting in process development, data analysis, and protocol documentationExecuting downstream processing steps, equipment setup, and process monitoring

In summary, Internship Downstream Process Development focuses on learning and supporting process optimization in a lab setting, while Downstream Process Technicians handle the hands-on execution of downstream manufacturing processes in production environments.

What are the most commonly searched types of Downstream Process Development jobs in California?

The most popular types of Downstream Process Development jobs in California are:

What cities in California are hiring for Internship Downstream Process Development jobs?

Cities in California with the most Internship Downstream Process Development job openings:

Internship Downstream Process Development jobs near you
Infographic showing various Internship Downstream Process Development job openings in California as of July 2026, with employment types broken down into 8% Internship, 84% Full Time, and 8% Contract. Highlights an 92% In-person, and 8% Remote job distribution.

Associate Director / Director, CMC Process Development

NGM Biopharmaceuticals

South San Francisco, CA • On-site

$180K - $220K/yr

Full-time

Re-posted 14 days ago

Job description

Associate Director / Director, CMC Process Development
Company Overview
NGM Biopharmaceuticals, Inc. is a privately held biotechnology company, focused on developing novel, life-changing medicines for people whose health and lives have been disrupted by disease. NGM Bio's biology-centric drug discovery approach aims to seamlessly integrate interrogation of complex disease-associated biology and protein engineering expertise to unlock proprietary insights that are leveraged to generate promising product candidates, enable their rapid advancement into proof-of-concept studies and address high unmet patient need. Currently, NGM Bio is advancing NGM120, a GDF15/GFRAL antagonist antibody, to address two significant and distinct unmet needs, both of which are rooted in overactivation of the GDF15 pathway: hyperemesis gravidarum (HG) and cancer cachexia.
Position Summary
Join the CMC team at NGM Bio! Our team is responsible for late-stage development and cGMP manufacturing of monoclonal antibody therapeutics. In this role, you will work with the Head of CMC Development to create and execute late-stage development strategies while providing technical oversight of CDMOs for upstream/downstream process development and cGMP manufacturing.
  • Location: South San Francisco, CA
  • Work Mode: Hybrid (Minimum 2 days on-site per week)
  • Travel: 10-20% domestic and international travel

Responsibilities
  • Serve as the technical CMC lead for a late-stage monoclonal antibody (mAb) project.
  • Provide technical oversight of CDMOs for upstream/downstream process optimization, scale-up, cGMP Drug Substance manufacturing, process characterization, and process validation.
  • Partner closely with Regulatory, Quality, Clinical Development, Program Management, and CDMO partners to ensure timely execution of CMC development plans.
  • Proactively identify upstream/downstream technical and operational risks and implement mitigation strategies to support development timelines.
  • Author, review, and approve protocols, technical reports, batch records, SOPs, and relevant sections of regulatory submissions.
  • Ensure strict adherence to cGMP guidelines and, quality and regulatory compliance.
  • Serve as a subject matter expert, including Person-in-Plant, during cGMP manufacturing, audits and regulatory interactions.

Required Experience
  • MS or PhD in Biotechnology, Biochemistry, Chemical Engineering, Chemistry, or a related field.
  • 8+ years of experience in upstream and/or downstream process development for biologics, CMC operations, and CDMO management.
  • Hands-on experience troubleshooting and optimizing biologics DS manufacturing processes and scaling up to pilot and commercial scale.
  • Deep expertise in process characterization and process qualification for commercialization.
  • Broad experience/working knowledge of formulation dev, drug product manufacturing (Vials/PFS) and or analytical development would be a plus.
  • Strong scientific problem-solving and root-cause analysis skills.
  • Extensive knowledge of GMP regulations, and CMC-related global regulatory guidelines for biologics.
  • Strong analytical, data interpretation, communication, and regulatory documentation skills.
  • Ability to work independently and effectively in a dynamic, fast-paced, collaborative small biotech environment.

Salary Ranges
At the time of posting, the wage range for this role is $180,000 - $220,000 for Associate Director level and $220,000 - $250,000 for Director level candidates located in the Bay Area.
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