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Internship Downstream Process Development Scientist Jobs in Trenton, NJ

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Process Scientist

Philadelphia, PA

... developed process to GMP manufacturing. A Scientist is a mid-level individual with understanding of cell/molecular biology and previous experience in either upstream or downstream biopharmaceutical ...

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How much do internship downstream process development scientist jobs pay per hour?

As of May 28, 2026, the average hourly pay for internship downstream process development scientist in Trenton, NJ is $38.77, according to ZipRecruiter salary data. Most workers in this role earn between $28.46 and $46.30 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Internship Downstream Process Development Scientist, and why are they important?

To thrive as an Internship Downstream Process Development Scientist, you need foundational knowledge in biochemistry, molecular biology, or chemical engineering, often supported by ongoing or recent enrollment in a relevant degree program. Familiarity with laboratory techniques such as chromatography, filtration, and analytical instruments, as well as experience with lab management software, is typically expected. Attention to detail, problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills and qualifications are crucial for conducting reliable experiments, analyzing data, and contributing to the optimization of bioprocesses in a collaborative research environment.

What types of projects and responsibilities can an Internship Downstream Process Development Scientist expect to work on?

As an Internship Downstream Process Development Scientist, you can expect to be involved in hands-on laboratory work focusing on the purification and characterization of biopharmaceutical products. Typical responsibilities include preparing buffer solutions, operating chromatography and filtration systems, analyzing samples using various analytical techniques, and documenting experimental results. Interns often collaborate with experienced scientists and engineers, contributing to process optimization and troubleshooting. The role provides valuable exposure to industry-standard procedures and the opportunity to develop technical skills in a team-oriented environment.

What does an Internship Downstream Process Development Scientist do?

An Internship Downstream Process Development Scientist works in the biopharmaceutical industry, assisting with the development and optimization of processes that purify biological products such as proteins, antibodies, or vaccines after they are produced by cells. Their role often involves supporting laboratory experiments, analyzing samples, and documenting results to improve the efficiency and scalability of downstream processes like filtration and chromatography. Interns in this position gain hands-on experience with cutting-edge technologies and learn about regulatory requirements and industry standards. This role helps prepare students or recent graduates for a career in process development or biomanufacturing.
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Internship Downstream Process Development Scientist jobs near you
Infographic showing various Internship Downstream Process Development Scientist job openings in Trenton, NJ as of May 2026, with employment types broken down into 2% Internship, 2% As Needed, 5% Full Time, 78% Part Time, 12% Contract, and 1% Nights. Highlights an 29% Physical, and 71% Remote job distribution, with an average salary of $80,641 per year, or $38.8 per hour.

Principal Scientist, Lentivirus Downstream Process Development

Legend Biotech US

Somerset, NJ • Hybrid

Other

Posted 28 days ago

Job description

Legend Biotech is seeking a Principal Scientist, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Principal Scientist, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in downstream processing (DSP)-including clarification, chromatography, TFF, sterile filtration and fill/finish-ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strategic thinking to accelerate timelines while maintaining a patient-focused approach.

Key Responsibilities

  • Design and execute highly efficient purification strategies for lentiviral vectors, specifically optimized for CAR-T applications.
  • Direct the development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
  • Provide hands-on training as needed.
  • Direct the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs
  • Lead the execution of study protocols to define operating parameters and performance limits; implement state-of-the-art knowledge management for DSP data.
  • Communicate the potential for issues and delays along with solutions and mitigation approaches.
  • In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
  • Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
  • Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
  • Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
  • Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
  • Tech transfer process to/from other Legend sites or CDMOs
  • Resolve conflict and proactively identify/address performance issues.
  • Ensure compliance with regulatory requirements. 

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, Virology, Molecular Biology, or a related field.
  • 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
  • Deep technical hands-on experience in purification, chromatography, and TFF specifically for viral vectors (Lentivirus preferred)
  • Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
  • Deep knowledge and hands-on experiences in cell and lentiviral vector technologies within the current emerging field
  • Ability to implement closed-system processes and maximize cost effectiveness
  • Strong knowledge in engineering modeling and optimization.
  • Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
  • Creative, strategic thinking
  • Strong troubleshooting skills
  • Preferred experience in developing vector processes tailored for CAR-T generation and systemic delivery
  • Preferred experience in handling large scale(>50L) purification process.
  • Language: English. Mandarin is a plus. 

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