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Internship Downstream Process Development Scientist Jobs in Maryland

US AI

Sr. Data Scientist

Rockville, MD

$150K - $200K/yr

Analyze raw data: assessing quality, cleansing, structuring for downstream processing * Design ... Demonstrated expertise gained through relevant internships, coursework, and personal projects that ...

Thermo Fisher Scientific

Scientist: HPLC

Rockville, MD · On-site

$25 - $40/hr

... Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join ... Downstream teams for process development and characterization projects • Co-author analytical ...

Thermo Fisher Scientific

Scientist: HPLC

Rockville, MD

$25 - $40/hr

... Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join ... Downstream teams for process development and characterization projects • Co-author analytical ...

Thermo Fisher Scientific

Scientist: HPLC

Rockville, MD

$27.41 - $45/hr

... Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join ... Downstream teams for process development and characterization projects • Co-author analytical ...

Thermo Fisher Scientific

Scientist: HPLC

Rockville, MD · On-site

$27.41 - $45/hr

... Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join ... Downstream teams for process development and characterization projects • Co-author analytical ...

AstraZeneca

Scientist

Gaithersburg, MD · On-site

Ability to solve process development problems and implement improved procedures. Education ... Experience working with multiple antibody formats, troubleshoot common downstream challenges such ...

AstraZeneca

Process Engineer

Rockville, MD · On-site

- Process Engineer, Manufacturing Sciences & Technology, Cell Therapy Location: AstraZeneca ... This position will report to Director, MS&T, Cell Therapy Development and Operations. Key ...

AstraZeneca

Process Engineer

Rockville, MD

- Process Engineer, Manufacturing Sciences & Technology, Cell Therapy Location: AstraZeneca ... This position will report to Director, MS&T, Cell Therapy Development and Operations. Key ...

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Internship Downstream Process Development Scientist information

What are the key skills and qualifications needed to thrive as an Internship Downstream Process Development Scientist, and why are they important?

To thrive as an Internship Downstream Process Development Scientist, you need foundational knowledge in biochemistry, molecular biology, or chemical engineering, often supported by ongoing or recent enrollment in a relevant degree program. Familiarity with laboratory techniques such as chromatography, filtration, and analytical instruments, as well as experience with lab management software, is typically expected. Attention to detail, problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills and qualifications are crucial for conducting reliable experiments, analyzing data, and contributing to the optimization of bioprocesses in a collaborative research environment.

What types of projects and responsibilities can an Internship Downstream Process Development Scientist expect to work on?

As an Internship Downstream Process Development Scientist, you can expect to be involved in hands-on laboratory work focusing on the purification and characterization of biopharmaceutical products. Typical responsibilities include preparing buffer solutions, operating chromatography and filtration systems, analyzing samples using various analytical techniques, and documenting experimental results. Interns often collaborate with experienced scientists and engineers, contributing to process optimization and troubleshooting. The role provides valuable exposure to industry-standard procedures and the opportunity to develop technical skills in a team-oriented environment.

What does an Internship Downstream Process Development Scientist do?

An Internship Downstream Process Development Scientist works in the biopharmaceutical industry, assisting with the development and optimization of processes that purify biological products such as proteins, antibodies, or vaccines after they are produced by cells. Their role often involves supporting laboratory experiments, analyzing samples, and documenting results to improve the efficiency and scalability of downstream processes like filtration and chromatography. Interns in this position gain hands-on experience with cutting-edge technologies and learn about regulatory requirements and industry standards. This role helps prepare students or recent graduates for a career in process development or biomanufacturing.
What are the most commonly searched types of Downstream Process Development Scientist jobs in Maryland? The most popular types of Downstream Process Development Scientist jobs in Maryland are:
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Internship Downstream Process Development Scientist jobs near you
Scientist, Viral Vector Process Development, Upstream

Scientist, Viral Vector Process Development, Upstream

AstraZeneca

Gaithersburg, MD • On-site

$92.25K - $138.38K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 10 days ago

AstraZeneca rating

8.6

Company rating: 8.6 out of 10

Based on 43 frontline employees who took The Breakroom Quiz

16th of 70 rated pharmaceutical

Job description

AstraZeneca is looking for a highly motivated Scientist, Viral Vector Process Development (Upstream). The candidate will play a critical role within a high performing team that accelerates AstraZeneca's emerging Cell Therapy modalities portfolio. You will design, execute, and optimize upstream Lentiviral Vector (LVV) processes with a primary focus on suspension bioreactor platforms at clinical and commercial scales. You will contribute hands-on to experimental design, process characterization, and scale-up/tech transfer activities from research through IND enabling, partnering closely with Research, Analytical
Development, CMC, Regulatory, Manufacturing, Quality, and external CDMOs. This position is based in Gaithersburg, MD.
Key Responsibilities:
  • Upstream Process Development: Plan and perform experiments to develop and optimize LVV upstream processes for suspension cell culture (transient or stable producer cell systems), targeting improvements in titer, quality, robustness, and cost.
  • Bioreactor Operations & Scale Translation: Execute unit operations across seed, production, and harvest interfaces; support scale-up strategies from bench to pilot and clinical scales; develop and use scale-down models for characterization and comparability.
  • Experimental Design & Data Analysis: Design DOE studies, identify CPPs/CMAs, analyze data and propose control strategies; document results in protocols and reports; maintain fit for purpose knowledge records.
  • Tech Transfer & GMP Interface: Prepare technical transfer packages and support transfers to internal GMP sites and CDMOs; align process documentation with cGMP principles for late-stage readiness.
  • Cross-Functional Collaboration: Work closely with Analytical Development on assay readiness and in process testing; partner with Manufacturing, Supply, and Quality to ensure operational feasibility and compliance.
  • Operational Excellence: Apply Lean practices and digital tools for scheduling, data integrity, and reproducibility; track KPIs (titer, infectivity, impurity profiles, cycle time, right first time) and recommend improvements.

Qualifications:
  • Education: MS/BS in Engineering, Biotechnology, or related field.
  • Years of experiences in industry: MS with 1-4 years; or BS with 3-6 years.
  • Experience: Handson experience developing suspension-based LVV upstream processes; familiarity with clinical scale considerations, and technology transfer.
  • Technical Skills: Proficiency in suspension cell culture, transfection/infection strategies, media/feed optimization, single use rocking-platform and stirred-tank bioreactors, and upstream-harvest interfaces;
  • Communication & Teamwork: Strong written and verbal communication skills; ability to work effectively in cross functional, matrixed teams; demonstrated problem solving and troubleshooting capabilities.

  • Preferred Qualifications:
  • Demonstrated success scaling suspension LVV processes to pilot/clinical scales and sustaining performance via monitoring and continuous improvement.
  • Experience linking upstream parameters to analytical outcomes (titer, infectivity/potency, residuals/impurities) to guide process decisions.
  • Contributions to regulatory filings (data tables, process descriptions) and participation in tech transfer to CDMOs or internal GMP sites.
  • Tools & Automation: Experience with single use systems, process automation/PAT, and digital lab systems (ELN/LIMS) preferred.
  • Experience implementing Lean/continuous improvement and robust documentation/knowledge management in PD labs

The annual base pay for this position ranges from $92,252.00 - $138,378.00. Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Date Posted
18-May-2026
Closing Date
28-May-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

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