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Information System Assistant Jobs in O Fallon, IL

IT Audit Analyst

O Fallon, IL · On-site

$48K - $56K/yr

Bachelor's Degree (Information Systems, Accounting or relevant field) * Must be currently located ... These tools assist our recruitment team but do not replace human judgment. Final hiring decisions ...

... System Controls Audit Manual (FISCAM) * Support with the execution of test plans to evaluate design and operating effectiveness of IT controls. As findings are addressed, the Contractor shall assist ...

The assistant laboratory I processes patients, specimens, orders, reports, requests; assists ... B) Records appropriate comments in the Hospital Information System when applicable. C) Collects and ...

The assistant laboratory I processes patients, specimens, orders, reports, requests; assists ... B) Records appropriate comments in the Hospital Information System when applicable. C) Collects and ...

The assistant laboratory I processes patients, specimens, orders, reports, requests; assists ... B) Records appropriate comments in the Hospital Information System when applicable. C) Collects and ...

Sr Business Analyst IT

Bridgeton, MO · On-site

$87K - $113K/yr

Conducts gap analysis between existing business systems and evolving customer requirements ... assistants including AI-powered requirements extraction, automated impact analysis, and intelligent ...

Sr Business Analyst IT

Bridgeton, MO · On-site

$87K - $113K/yr

Conducts gap analysis between existing business systems and evolving customer requirements ... assistants including AI-powered requirements extraction, automated impact analysis, and intelligent ...

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Information System Assistant information

What does an information system assistant do?

An Information System Assistant supports the maintenance and operation of an organization’s computer systems and networks. Their responsibilities typically include troubleshooting technical issues, assisting with software and hardware installations, helping users with IT problems, and ensuring data security protocols are followed. They often work under the supervision of IT managers or system administrators and may also help with system upgrades and documentation. Their work is essential for keeping technology infrastructure running smoothly and efficiently.

What are some common challenges information system assistants face when supporting end-users, and how can these be managed effectively?

Information System Assistants often encounter challenges such as troubleshooting a wide range of technical issues for users with varying skill levels. Communicating complex technical concepts in a clear and patient manner is essential, as is managing multiple support requests simultaneously. Effective time management, strong problem-solving skills, and maintaining thorough documentation help address these challenges. Building strong working relationships with colleagues and staying updated on the latest system updates also contribute to smoother support operations.

What are the key skills and qualifications needed to thrive as an information system assistant, and why are they important?

To thrive as an Information System Assistant, you need a solid understanding of computer systems, troubleshooting, and IT support, often backed by an associate degree or relevant certifications like CompTIA A+. Familiarity with operating systems, ticketing software, and network administration tools is typically required. Strong problem-solving, communication, and organizational skills help you effectively support users and prioritize tasks. These abilities ensure efficient system operations and timely resolution of technical issues, supporting overall organizational productivity.

What is the difference between Information System Assistant vs Network Support Technician?

AspectInformation System AssistantNetwork Support Technician
CredentialsTypically requires an associate degree or relevant certifications like CompTIA A+Often requires similar certifications, with additional networking-specific ones like Cisco CCNA
Work EnvironmentWorks in offices, IT departments, supporting internal usersWorks in technical environments, troubleshooting network issues
Employer & IndustryCommon in various industries, supporting IT infrastructurePrimarily in telecommunications, IT services, and network-focused companies
Search & Comparison IntentOften compared for entry-level IT roles, supporting systems and usersCompared for specialized network troubleshooting roles

The main difference is that an Information System Assistant provides broader support for IT systems and user assistance, while a Network Support Technician specializes in network infrastructure and troubleshooting. Both roles require similar certifications and work environments but focus on different technical areas within IT support.

Is information system assistant a good career?

An information system assistant is a role that involves supporting and maintaining computer systems, networks, and software within organizations. It can be a good career for those interested in IT support, troubleshooting, and technical problem-solving, often requiring knowledge of hardware, software, and basic networking. Job prospects are generally stable, with opportunities for advancement into more specialized IT roles or system administration positions.

What job categories do people searching Information System Assistant jobs in O Fallon, IL look for?

The top searched job categories for Information System Assistant jobs in O Fallon, IL are:

What cities near O Fallon, IL are hiring for Information System Assistant jobs?

Cities near O Fallon, IL with the most Information System Assistant job openings:

Infographic showing various Information System Assistant job openings in O Fallon, IL as of July 2026, with employment types broken down into 1% As Needed, 71% Full Time, 25% Part Time, 1% Temporary, and 2% Contract. Highlights an 93% Physical, 3% Hybrid, and 4% Remote job distribution.

Information Systems Security Engineer

O Fallon, IL

Amyx, Inc.
IT Services • 201 - 500 employees

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 27 days ago


Job description

Amyx is seeking several Information Systems Security Engineers (ISSE) personnel to support the US Transportation Command (TRANSCOM) Senior Information Security Officer (SISO) contract at Scott Air Force Base, IL.

In support of USTRANSCOM risk management processes, the ISSE shall assess potential risks, mitigation measures, residual risks, and provide Security Risk Assessment recommendations to the Government. The individual shall research and advise the SISO and other Government staff on recently developed countermeasures designed to protect command systems from new threats and shall assist in the development, implementation, and administration of effective security programs for approval by the Government and provide guidance, cyber alerts, and best practice information to the appropriate audience.


• Conduct risk assessments to determine the risk posed by the integration of new systems or capabilities into the USTRANSCOM environment.
• As required, obtain supporting data from other DoD/Federal organizations, vendors, or Internet research to support RMF requirements.
• Conduct risk assessments in accordance with the principles of NIST SP 800-30, Guide for Conducting Risk Assessments, and the principles of NIST SP 800-160 Vol I and Vol II, and security best practices.
• Maintain current documentation on ISSE processes and procedures and provide direct support for generation and delivery of all required contract deliverables.
• Implements security measures in accordance with applicable ICDs, NISP, NIST, and guiding government regulations and local facility procedures.
• Conducts ongoing vulnerability testing of the information system to verify security features and operating controls are functional, effective and meet government standards.
• Interact with internal and external customers or government security officials to perform security duties, address routine information security matters with employees regarding issues.

• Must have the ability to communicate accurate information

Technology used:

RMF, NIST, DevSecOps, SSH, HBSS


Required skills:

• Minimum of 5 years of related experience
• Secret security clearance
• DoD 8570 IAT-II Certification
• Must have proficiency with various computer applications and testing tools (Word, Excel, PowerPoint, DISA STIG Viewer, Nessus, etc.).
• Must have experience in certification and accreditation process of information systems and ability to write, review and coordinate system security plans.
• Excellent written and verbal communication skills, demonstrating the ability to present material to senior DoD and non-DoD officials.
• Able to communicate effectively with senior leaders and customers to clearly present technical approaches and findings.

Desired Skills:

• BA/BS degree from an accredited university
• Demonstrated knowledge and understanding of the USTRANSCOM mission
• IAM-II or greater certification

Benefits include:

  • Medical, Dental, and Vision Plans (PPO & HSA options available)
  • Flexible Spending Accounts (Health Care & Dependent Care FSA)
  • Health Savings Account (HSA)
  • 401(k) with matching contributions
  • Roth
  • Qualified Transportation Expense with matching contributions
  • Short Term Disability
  • Long Term Disability
  • Life and Accidental Death & Dismemberment
  • Basic & Voluntary Life Insurance
  • Wellness Program
  • PTO
  • 11 Holidays
  • Professional Development Reimbursement

Please contact talent@amyx.com with any questions!

Amyx is proud to be an Equal Opportunity Employer.  All qualified candidates will be considered without regard to race, color, religion, national origin, age, disability, sexual orientation, gender identity, status as a protected veteran, or any other characteristic protected by law. Amyx is a VEVRAA federal contractor and we request priority referral of veterans.


Physical Demands
Employee needs to be able to sit at a workstation for extended periods; use hand(s) to handle or feel objects, tools, or controls; reach with hands and arms; talk and hear. Most positions require ability to work on desktop or laptop computer for extended periods of time reading, reviewing/analyzing information, and providing recommendations, summaries and/or reports in written format. Must be able to effectively communicate with others verbally and in writing. Employee may be required to occasionally lift and/or move moderate amounts of weight, typically less than 20 pounds. Regular and predictable attendance is essential.