Human Systems Integration Jobs in California (NOW HIRING)

What if the work you did every day could impact the lives of people you know? Or all of humanity?
At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.
Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.
As a Systems Integration Engineer 1 at Illumina, you will work in a collaborative, team-oriented environment to help develop and test genomic analysis tools at the leading edge of research. You will contribute to the delivery of high-quality, robust products through the integration of hardware, software, chemistry, and biological assay components. A key aspect of this role is executing structured experiments, diagnosing complex system-level issues, and collaborating with cross-functional teams to drive problems to root cause.
Key Responsibilities

• Perform hands-on integration, testing and troubleshooting of DNA sequencing systems and assay platforms, with a focus on chemical or biochemical assay workflows
• Execute system-level troubleshooting across biochemical assays, hardware, software, and application components
• Investigate technical problems by analyzing data, forming hypotheses, and proposing practical solutions in collaboration with cross-functional colleagues
• Track, log and communicate issues encountered during development using established documentation and issue-tracking processes
• Apply analytical techniques and tools to analyze experimental and system-level data, identify trends, and support data-driven decision making
• Execute design verification plans, collect and review data, and contribute to verification reports
• Author and maintain clear documentation of experimental procedures, protocols, results, deviations, and observations
• Work effectively within cross-functional project teams (research, product development, manufacturing, etc.)
• Present technical findings, risks, and recommendations to engineering and scientific stakeholders

Minimum Requirements

• Foundational understanding of, or keen interest to learn sequencing systems, assay platforms, and associated wet laboratory techniques
• Hands-on wet laboratory experience (academic or industry) working with biochemical assays, instrumentation, or complex experimental workflows.
• Broad scientific knowledge across disciplines such as molecular biology, chemistry, software, instrumentation, and data analysis
• Ability to analyze and draw conclusions from large data sets
• Familiarity with AI tools, scientific programming or scripting (e.g., Python) for data analysis is preferred
• Strong interpersonal and communication skills, with the ability to engage effectively in technical discussions across assay, software, engineering, or manufacturing teams
• Detail-oriented, self-motivated, and collaborative, with the ability to clearly communicate technical information to both technical and non-technical audiences
• Comfortable working in a fast-paced, multidisciplinary, and evolving research and development environment

Education/Experience

• Typically requires 0 to 2 years of relevant professional experience (including internships, co-ops, or academic research)
• Bachelors or Master's degree in engineering or science discipline (Bioengineering, Chemical Engineering, Biochemistry, Biology, or a related field)
• Complex system troubleshooting skills
• Ability to think critically, learn quickly, and adapt to changing priorities and development needs.
• Aptitude for independent research in addition to working well within a team

Strong preference will be given to individuals with intense curiosity about the world around them and demonstrated ability for digging deep into experimental methods and results.
The estimated base salary range for the Systems Integration Engineer 1 role based in the United States of America is: $68,400 - $102,600. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long-term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.
We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.