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High Resolution Mass Spectrometry Jobs (NOW HIRING)

ALS

Technical Manager

Houston, TX · On-site

HRMS (High Resolution Mass Spectrometry) experience is required. * 10+ years of technical experience is preferred. * 5+ years of laboratory experience is preferred. * Strong experience with EPA ...

ALS

Technical Manager

Houston, TX · On-site

HRMS (High Resolution Mass Spectrometry) experience is required. * 10+ years of technical experience is preferred. * 5+ years of laboratory experience is preferred. * Strong experience with EPA ...

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$114.5K

How much do high resolution mass spectrometry jobs pay per year?

As of Jun 14, 2026, the average yearly pay for high resolution mass spectrometry in the United States is $70,345.00, according to ZipRecruiter salary data. Most workers in this role earn between $50,000.00 and $86,500.00 per year, depending on experience, location, and employer.

What are the typical day-to-day responsibilities for someone working in High Resolution Mass Spectrometry?

Professionals in High Resolution Mass Spectrometry are responsible for preparing samples, operating mass spectrometry instruments, performing method development, and interpreting complex analytical data. They often collaborate with colleagues in research, quality control, or product development to support broader scientific or manufacturing objectives. Daily tasks also include routine instrument maintenance, troubleshooting technical issues, and clearly documenting experimental results. Working in this role offers exposure to cutting-edge analytical technologies and provides opportunities to contribute to projects in pharmaceuticals, environmental science, or biotechnology.

What is a simile for high?

In the context of High Resolution Mass Spectrometry, 'high' can be compared to something that is elevated or at an advanced level, such as a mountain peak or a soaring bird, indicating superior resolution or sensitivity. This simile emphasizes the instrument's ability to detect and analyze very small differences in mass with precision. Understanding the 'high' resolution capabilities is essential for accurate identification of complex molecules in analytical chemistry.

What are synonyms for high?

In the context of high resolution mass spectrometry, synonyms for high include terms like elevated, advanced, or superior, which describe the level of detail or precision in the instrument's measurements. These terms emphasize the instrument's capability to distinguish between closely related molecular masses, often requiring specialized training and calibration. Understanding these synonyms helps in accurately communicating the instrument's performance in scientific and technical settings.

What are the key skills and qualifications needed to thrive in the High Resolution Mass Spectrometry position, and why are they important?

To thrive in High Resolution Mass Spectrometry, you need a solid background in analytical chemistry, experience with advanced mass spectrometry techniques, and typically a degree in chemistry, biochemistry, or a related field. Familiarity with instrumentation such as Orbitrap or time-of-flight mass spectrometers, data analysis software, and relevant laboratory certifications is highly valuable. Strong problem-solving skills, attention to detail, and effective communication help set candidates apart in this highly technical environment. These qualities are essential for producing accurate and reliable analytical results, ensuring safety, and collaborating effectively within research or quality assurance teams.

What is a High Resolution Mass Spectrometry job?

A High Resolution Mass Spectrometry (HRMS) job involves analyzing chemical compounds with high accuracy and precision using advanced mass spectrometers. Professionals in this role work in laboratories across industries like pharmaceuticals, environmental science, and forensics to identify and quantify complex molecules. Responsibilities may include sample preparation, data interpretation, instrument maintenance, and ensuring compliance with regulatory standards. Strong analytical skills and expertise in mass spectrometry techniques are essential for success in this field.

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High Resolution Mass Spectrometry jobs near you
Infographic showing various High Resolution Mass Spectrometry job openings in the United States as of June 2026, with employment types broken down into 13% Locum Tenens, 5% Full Time, 3% Contract, 74% Nights, and 5% Summer. Highlights an 89% Physical, 4% Hybrid, and 7% Remote job distribution, with an average salary of $70,345 per year, or $33.8 per hour.

Scientist, Mass Spec & Characterization, Biosimilars ARD

Kashiv BioSciences, LLC

Piscataway, NJ

$35.25 - $44.25/hr

Other

Posted 28 days ago

Job description

Description

SUMMARY:


We are seeking a highly motivated, well-organized, and detail-oriented scientist who can work effectively in a fast-paced and multi-disciplinary environment. The position is in the ARD laboratory of Kashiv's Piscataway facility in NJ. The Scientist Mass Spec and Characterization will be responsible for development of LC-MS methods for protein characterization along with other analytical tools involving HPLCs and UV Spectrophotometry. Additional responsibilities include support of method transfer to QC laboratories when required and liaising with CROs and other R&D labs of Kashiv BioSciences. Basic LC-MS and HPLC operation experience is required. Experience with sequence elucidation of protein using LC-MS/MS is desired. The candidate must have experience authoring SOPs and technical reports and should be able to collaborate laboratories for method and data transfer.


Essential Duties and Responsibilities:


Development of LC-MS methods and workflow for sequence elucidation and identification of sites of chemical modification in the sequence.

Development of chromatography methods for quantification of related impurities.

Support sample testing as necessary for various stages of biosimilar development

Provide technical inputs to team members with respect to HPLC/UPLC troubleshooting, method development, method validation, etc.

Ensure adherence to highest quality and efficiency standards in laboratory operations (cGLP, cGMP)

Develop, optimize, and validate new chromatography methods using literature references and scientific principles.

Implement and when necessary, optimize compendial test methods.

Independently write experiment summaries, development reports, technical reports, operation and test method procedure documents, and review documents comprising, but not limited to standard operating procedures, standard test methods, validation protocols and reports, etc.

Foster morale and teamwork. Perform MS analyses of biologics. These studies include but are not limited to, protein molecular weight analysis, peptide mapping, protein sequencing, post-translational modifications qualitative and quantitative analyses, and glycan structural analysis using primarily but not solely high-resolution mass spectrometry.

Prepare chemical solutions and perform detailed and complex analytical procedures (e.g., digestions, purifications, buffer exchanges, etc.) following SOP and established test protocols.

Write and review reports, protocols, and any documentation in relation to the performance of the work.

Work closely with Quality Assurance to meet all necessary regulatory requirements.

Requirements


PREREQUISITES:


Education:


Minimum B.S. degree in Analytical Chemistry, Biophysical/Biochemical Sciences, Pharmaceutical Sciences with 5 years industry experience

Or Master's Degree in Biochemistry, Biotechnology, Biology with 2+ years' experience in protein mass spectrometry

Or Ph.D. in Biochemistry, Biotechnology, Biology with 1+ years of experience in protein mass spectrometry

Experience:

A strong theoretical understanding and experience in protein chemistry and biochemistry.

Experience with operation of LC-MS, HPLC and UV techniques is required.

Experience with HPLC methods like peptide mapping, SEC, CEX is required.

Protein sequencing experience is derived.

Familiar with ICH guidelines and USP/EP pharmacopeia requirements

Excellent communication and technical writing skills

Experience in method development, as well as method qualification/verification/validation in a GLP/GMP environment

Strong experience in analytical method development and validation

Demonstrated skills as a team-player.

Apply