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Full Time Downstream Process Development Scientist Jobs in Seattle, WA

BrainChild Bio

Process Engineer

Seattle, WA · On-site

$105K - $115K/yr

Qualifications: 4-5+ years in life sciences supporting process development or manufacturing process improvement and support activities preferably in cell therapy Proficiency with life science data ...

BrainChild Bio

Process Engineer

Seattle, WA · On-site

$105K - $115K/yr

Qualifications: * 4-5+ years in life sciences supporting process development or manufacturing process improvement and support activities preferably in cell therapy * Proficiency with life science ...

BrainChild Bio

Process Engineer

Seattle, WA · On-site

$105K - $115K/yr

Qualifications: • 4-5+ years in life sciences supporting process development or manufacturing process improvement and support activities preferably in cell therapy • Proficiency with life science ...

Syner-G

Vice President, Biologics

Seattle, WA · Remote

... science and delivery of life-enhancing therapies to more patients. We work across a diverse range ... Provide expert guidance across biologics development including upstream and downstream process ...

Amazon

Sr. Applied Scientist, Prime AI/ML Science

Seattle, WA · On-site

$104K - $142K/yr

... processes for large scale data analyses, science development, science validation and model implementation. - Analyze and extract relevant information from large amounts of Amazon's historical ...

Amazon

Sr. Applied Scientist, Prime AI/ML Science

Seattle, WA · On-site

$104K - $142K/yr

... processes for large scale data analyses, science development, science validation and model implementation. - Analyze and extract relevant information from large amounts of Amazon's historical ...

Evotecgroup

Process Engineer 2

Redmond, WA

Lead the development equipment maintenance & life cycle plans * Partner with Site MSAT ... Position Requirements: * BS in engineering, sciences, or related life science engineering 2-5 years ...

Evotec

Process Engineer 2

Redmond, WA · On-site

Lead the development equipment maintenance & life cycle plans * Partner with Site MSAT ... Position Requirements: * BS in engineering, sciences, or related life science engineering 2-5 years ...

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All JobsDownstream Process Development Scientist JobsFull Time Downstream Process Development Scientist JobsFull Time Downstream Process Development Scientist Jobs in Seattle, WA

Full Time Downstream Process Development Scientist information

See Seattle, WA salary details

$23

$44

$70

How much do full time downstream process development scientist jobs pay per hour?

As of Sep 4, 2026, the average hourly pay for full time downstream process development scientist in Seattle, WA is $44.00, according to ZipRecruiter salary data. Most workers in this role earn between $32.26 and $52.50 per hour, depending on experience, location, and employer.

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

How much does a full time downstream process development scientist make?

In California, a full-time downstream process development scientist typically earns between $80,000 and $130,000 annually, depending on experience, education, and the specific employer. Salaries may also include benefits such as health insurance and bonuses, with higher compensation often associated with advanced skills in bioprocessing and laboratory techniques.

What is a full time downstream process development scientist?

A full-time downstream process development scientist specializes in designing, optimizing, and scaling the purification processes used in biopharmaceutical manufacturing, such as chromatography and filtration. They work to improve product yield, purity, and efficiency, often using laboratory techniques and process modeling tools, typically within a regulated environment requiring compliance with industry standards.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Seattle, WA?

The most popular types of Downstream Process Development Scientist jobs in Seattle, WA are:

What are popular job titles related to Full Time Downstream Process Development Scientist jobs in Seattle, WA?

For Full Time Downstream Process Development Scientist jobs in Seattle, WA, the most frequently searched job titles are:

What job categories do people searching Full Time Downstream Process Development Scientist jobs in Seattle, WA look for?

The top searched job categories for Full Time Downstream Process Development Scientist jobs in Seattle, WA are:

What cities near Seattle, WA are hiring for Full Time Downstream Process Development Scientist jobs?

Cities near Seattle, WA with the most Full Time Downstream Process Development Scientist job openings:

Full Time Downstream Process Development Scientist jobs near you
Infographic showing various Full Time Downstream Process Development Scientist job openings in Seattle, WA as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $91,520 per year, or $44 per hour.

Principal Scientist, Chemical Development

Immunome, Inc.

Bothell, WA • On-site

Full-time

Posted 14 days ago

Job description

Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.
Position Overview
We are seeking an experienced Principal Scientist, Chemical Development to join our dynamic team to help advance our pipeline of innovative targeted cancer therapies. The successful candidate will apply their expertise in small molecule process development and manufacturing to support a variety of modalities in the Immunome pipeline with a focus on small molecule linker-payload targets for ADCs. This person will play a key role in leading challenging drug candidate process development programs, enabling treatment of patients in need.
Responsibilities
Leadership
  • Provide technical leadership as a key member of the chemical development team while maintaining alignment with the company's goals and objectives.
  • Function as the technical lead on at least one program while also functioning as an individual technical contributor.
  • Provide guidance and leadership to external partners working towards the successful advancement of antibody drug conjugates, radiopharmaceuticals, and other lead programs.
  • Support programs at the bench as an individual contributor as needed.

Technical Expertise
  • Leverage knowledge and experience in the development and execution of robust and scalable small molecule synthetic processes.
  • Devise and evaluate alternative routes of synthesis with the aim of developing robust and efficient routes to APIs while reducing cost of goods (COGs) and shortening manufacturing lead times.
  • Develop robust data packages for technical transfer of processes for manufacturing partners at external CMOs.
  • Maintain knowledge of the current state of the art in synthetic methods utilized for the construction of complex molecules.
  • Carry out thorough analytical data collection both as an individual contributor in the lab as well as via oversight and review of data collected at our external partners.
  • Contribute to authoring relevant sections of various regulatory documents (IND, IMPD, NDA, briefing books, etc.) and provide SME support for related regulatory inquiries.

Cross-Functional Collaboration
  • Execute the integrated CMC regulatory strategies for pipeline programs.
  • Collaborate with research, regulatory affairs, and CMC teams to ensure seamless coordination of activities.
  • Provide feedback to research on synthetic routes and raw materials that are CMC friendly.
  • Foster strong collaborations with internal and external stakeholders.
  • Engage colleagues in discovery chemistry to provide CMC input of target molecules under evaluation for future development.

Innovation
  • Stay abreast of the latest advancements in synthetic methodology as well as new technologies and methodologies to enhance our capabilities.
  • Advance Immunome's intellectual property portfolio.

Quality and Compliance
  • Ensure compliance with relevant regulatory guidelines and industry standards for chemical development processes.
  • Uphold high-quality standards and address any compliance issues.

Qualifications
  • PhD in Synthetic Organic Chemistry or similar with a minimum of 7 years of industry experience leading small molecule and/or linker-payload programs, or equivalent combination of education and experience.
  • Experience as a technical lead overseeing tech transfer, process development and implementation of processes for manufacture at internal and/or external manufacturers is a plus.
  • Occasional evening and/or weekend commitment.
  • Ability to travel domestically and internationally (5-15%).

Knowledge and Skills
  • Ability to design cost effective robust manufacturing processes for complex small molecule targets as well as troubleshoot and solve complex technical challenges quickly.
  • Brings a collaborative and open-minded attitude when working with various internal and external teammates.
  • Meticulous and detail-oriented scientist with the ability to operate as an individual contributor at the bench while also managing external partners.
  • Proficient in generating robust and reliable analytical data utilizing various technologies in a hands-on capacity as well as evaluation of analytical data generated at external partners.
  • Proficient in writing technical reports and formulating presentations
  • Ability to develop cross functional relationships with discovery chemistry and other pre-clinical groups.
  • Experience in leading and managing technology transfers to third party process development and manufacturing partners.
  • Knowledge of cGMP requirements and ICH guidelines related to CMC small molecule drug-substance development and manufacturing.
  • Track record of working closely with cross-functional teams in a biopharmaceutical or pharmaceutical environment.
  • Excellent interpersonal and communication skills.

Washington State Pay Range
$169,593-$206,233 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
E-Verify
Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).

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