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Full Time Downstream Process Development Scientist Jobs in Tennessee

Sr. Research Scientist

Johnson City, TN

$94K - $120K/yr

The Senior Research Scientist is responsible for leading the development of innovative skincare and ... Partner closely with Process Development and Manufacturing teams to support formulation scale-up ...

Sr. Research Scientist

Johnson City, TN · On-site

$94K - $120K/yr

The Senior Research Scientist is responsible for leading the development of innovative skincare and ... Partner closely with Process Development and Manufacturing teams to support formulation scale-up ...

Your Main Responsibilities * Lead new process design/development activities * Identify ... Bachelor of Science in Mechanical, Industrial, MIT or similar field of study. * Software: Excel ...

Showing results 21-40

Full Time Downstream Process Development Scientist information

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Tennessee?

The most popular types of Downstream Process Development Scientist jobs in Tennessee are:

What are popular job titles related to Full Time Downstream Process Development Scientist jobs in Tennessee?

For Full Time Downstream Process Development Scientist jobs in Tennessee, the most frequently searched job titles are:

What job categories do people searching Full Time Downstream Process Development Scientist jobs in Tennessee look for?

The top searched job categories for Full Time Downstream Process Development Scientist jobs in Tennessee are:

What cities in Tennessee are hiring for Full Time Downstream Process Development Scientist jobs?

Cities in Tennessee with the most Full Time Downstream Process Development Scientist job openings:

Infographic showing various Full Time Downstream Process Development Scientist job openings in Tennessee as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution.

AI/Machine Learning Research Scientist (Remote Eligible)

Oak Ridge National Laboratory

Maryville, TN • On-site, Remote

$145K - $177K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

This job post has expired today. Applications are no longer accepted.


Oak Ridge National Laboratory rating

8.8

Company rating: 8.8 out of 10

Based on 16 frontline employees who took The Breakroom Quiz

14th of 120 rated laboratories


Job description

Requisition Id 16762
Annual Salary Range:$$145,170.00 -$$177,430.00
Work-Site Type: Remote
ORNL offers a flexible work environment that supports both the organization and the employee. In addition, this position is considered remote-eligible for ORNL in pre-approved locations. Remote-eligibility is not a continued guarantee and could be subject to change based on evolving organizational needs.
Note about pay range:
Please note that the pay range information is a general guideline only. Many factors are taken into consideration when setting starting pay. Salary for this position will be commensurate with the final candidate's qualifications and experience, including skills, knowledge, relevant education, certifications, plus also aligned with the internal peer group. It is not typical for an individual to be offered a salary at or near the top of the range for a position. Link to benefits. https://jobs.ornl.gov/content/Benefits/?locale=en_US
Overview:
We are seeking a Machine Learning Research Scientist who will support the development of fundamentals for GeoAI imagery processing, self-supervised learning methods for large vision-language models to enable downstream imagery perception tasks including object detection and counting, visual question answering, semantic segmentation, and change detection. This position resides in the GeoAI Research Group in the Geographic Data Science Section, Geospatial Science and Human Security Division, National Security Sciences Directorate, at Oak Ridge National Laboratory (ORNL).
As part of our team, you will support research tasks related to image preprocessing pipelines including pansharpening, geocoding, atmospheric compensation, image denoising, cloud masking, finetuning large geospatial foundation models for a variety of national security downstream tasks. The GeoAI Group is part of the Geospatial Science and Engineering Division (GSED) at ORNL. The group conducts cutting edge research and publishes from novel machine learning based solutions to large scale geospatial application solutions. Research activities include the design of efficient image preprocessing pipelines, machine learning workflows using high performance computing techniques, and conducting post-processing and validations of model of outcomes. Under the guidance of senior research scientists, the selected applicant will take roles on multidisciplinary teams supporting cutting-edge research and engineering projects, deploying workflows on large-scale computing environments, leveraging ORNL's Frontier for its dense GPU-based high-performance computing resources to train large GeoAI models.
Major Duties/Responsibilities:
  • Develop and execute accelerated imagery preprocessing pipelines for high resolution satellite imagery
  • Develop and execute workflows to support finetuning large geospatial vision models
  • Collect, process, and analyze large volumes of satellite imagery
  • Support the design and implementation of efficient computer vision techniques
  • Visualize and communicate research results through technical reports, and peer-reviewed publications
  • Collaborate with other research and technical professionals on new methods to advance GeoAI methods
  • Deliver strong science and engineering artifacts demonstrating research innovation for our sponsors
  • Deliver ORNL's mission by aligning behaviors, priorities, and interactions with our core values of Impact, Integrity, Teamwork, Safety and Service. Promote equal opportunity by fostering a respectful workplace - in how we treat one another, work together, and measure success.

Basic Qualifications:
  • A PhD degree in electrical engineering, civil engineering, geoinformation science, or a related discipline
  • A minimum of 4 years of applied experience
  • Hands-on experience with training machine learning models on high performance computing infrastructures leveraging GPU accelerators
  • Experiences building satellite imagery preprocessing workflows
  • Experience using Python or other programming languages to develop AI algorithms in PyTorch computing framework

Preferred Qualifications:
  • Experience working with spatio-temporal datasets and remote sensing imagery
  • Knowledge of distributed computing and uncertainty quantification
  • Ability to function well in a fast-paced research environment, set priorities to accomplish multiple tasks within deadlines, and adapt to ever changing needs

Special Requirements:
  • Visa sponsorship is not available for this position.
  • This position requires the ability to obtain and maintain a Secret Compartmented Information (SCI) clearance from the Department of Energy. As such, this position is a Workplace Substance Abuse (WSAP) testing designated position. WSAP positions require passing a pre-placement drug test and participation in an ongoing random drug testing program. In addition, due the SCI, you may also be subject to random polygraph testing.

About ORNL:
As a U.S. Department of Energy (DOE) Office of Science national laboratory, ORNL has an impressive 80-year legacy of addressing the nation's most pressing challenges. Our team is made up of over 7,000 dedicated and innovative individuals! Our goal is to create an environment where a variety of perspectives and backgrounds are valued, ensuring ORNL is known as a top choice for employment. These principles are essential for supporting our broader mission to drive scientific breakthroughs and translate them into solutions for energy, environmental, and security challenges facing the nation.
ORNL offers competitive pay and benefits programs to attract and retain individuals who demonstrate exceptional work behaviors. The laboratory provides a range of employee benefits, including medical and retirement plans and flexible work hours, to support the well-being of you and your family. Employee amenities such as on-site fitness, banking, and cafeteria facilities are also available for added convenience.
Other benefits include the following: Prescription Drug Plan, Dental Plan, Vision Plan, 401(k) Retirement Plan, Contributory Pension Plan, Life Insurance, Disability Benefits, Generous Vacation and Holidays, Parental Leave, Legal Insurance with Identity Theft Protection, Employee Assistance Plan, Flexible Spending Accounts, Health Savings Accounts, Wellness Programs, Educational Assistance, Relocation Assistance, and Employee Discounts.
This position will remain open for a minimum of 5 days after which it will close when a qualified candidate is identified and/or hired.
We accept Word (.doc, .docx), Adobe (unsecured .pdf), Rich Text Format (.rtf), and HTML (.htm, .html) up to 5MB in size. Resumes from third party vendors will not be accepted; these resumes will be deleted and the candidates submitted will not be considered for employment.
If you have trouble applying for a position, please email ORNLRecruiting@ornl.gov.
ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected veterans, are encouraged to apply. UT-Battelle is an E-Verify employer.

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