As a flu shot RN, your main duties are to administer the influenza vaccine to patients at a doctor’s office, in a hospital, or in another health care facility, such as a flu clinic. You also provide each patient with information and education about flu season and how to remain healthy. Flu shot nurses also coordinate and implement wellness programs and screening services for offices, companies, and schools. Screening responsibilities include measuring biometric data, such as blood pressure and temperature, and providing information about wellness plans.