Executive Variant Curation Jobs in California (NOW HIRING)

A Rare Opportunity to Shape the Future of Genomics
Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.
Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.
If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.
We are seeking a highly driven leader for one of the most critical and high-impact roles at BillionToOne: the Senior Director of Software Product Management & Product Engineering.
In this role, you will lead the organization responsible for building and scaling BillionToOne's software products and platforms across both our oncology and prenatal businesses. This includes external customer-facing experiences such as provider portals and patient portals, as well as mission-critical internal software platforms such as an internal variant curation and report generation platform.
This is a unique opportunity for a product-first technology leader who combines exceptional product management instincts with strong engineering leadership experience. The ideal candidate is deeply customer-centric, understands how to build scalable and elegant software systems, embraces an AI-first mindset, and has experience leveraging emerging AI capabilities to deliver differentiated customer experiences and operational advantage. This leader should also have experience managing engineering organizations while maintaining a strong product and business mindset.
You will oversee both the Software Product Management and Software Product Engineering organizations, partnering closely with Clinical Product, IT/IS, Data Science, Bioinformatics, Operations, Commercial, and Executive Leadership teams to deliver category-defining software experiences and operational platforms that create a durable competitive advantage.
This is a hybrid (onsite 3 days/week) position reporting directly to the Chief Product Officer.
Responsibilities:

• Lead and manage the Software Product Management and Software Product Engineering organizations across oncology and prenatal software products
• Define and execute the software product and platform strategy for provider portals, patient experiences, operational platforms, and internal workflow tools
• Drive an AI-first approach across both product development and engineering operations, leveraging modern AI technologies and tools to accelerate development and improve software quality and team productivity
• Identify opportunities to transform emerging AI capabilities into differentiated customer-facing products and meaningful customer value
• Partner closely with Clinical Product, Data Science, Bioinformatics, IT/IS, Operations, and Commercial teams to deliver category-defining software experiences and operational platforms
• Lead engineering managers and software engineering teams responsible for architecture, development, infrastructure, quality, scalability, and operational excellence
• Establish strong product and engineering operating mechanisms, execution frameworks, and prioritization processes to ensure predictable, high-quality software delivery
• Build a high-performance culture centered around customer obsession, ownership, speed, technical excellence, and business impact
• Serve as the company's leading expert on customer workflows and software user experience across provider, patient, and internal operational systems

Qualifications:

• 10+ years of experience in software product management, software engineering, or technology leadership roles with increasing organizational responsibility
• Strong product management background with demonstrated end-to-end ownership of complex software products and platforms
• Experience managing software engineering organizations and engineering leaders
• Proven ability to lead both product and engineering functions simultaneously
• Track record of building and scaling customer-facing software products and/or complex operational software systems
• Strong understanding of software architecture, platform development, system scalability, and engineering tradeoffs
• Experience leveraging AI technologies and AI-enabled development workflows to deliver customer and business value
• Strong product instincts with the ability to identify and translate emerging technologies into practical customer-facing solutions
• Excellent leadership, communication, and cross-functional collaboration skills
• Highly entrepreneurial mindset with the ability to operate strategically while remaining hands-on when needed
• Experience operating in fast-paced, high-growth environments with ambiguity and rapid iteration

Nice-to-Haves:

• Experience in healthcare, diagnostics, life sciences, genomics, or regulated environments
• Experience building provider-facing or patient-facing healthcare software products
• Strong experience with US healthcare technologies and ecosystems, including healthcare data, interoperability standards, and clinical workflow systems
• Experience working closely with AI, machine learning, or data platform teams
• Prior experience leading organizations through significant scale and organizational growth

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousand patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for eligible employees (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Free daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).
For this position, we offer a total compensation package of up to $580,140 per year, including a base pay range of $257,243 - $300,117 per year.
BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
For more information about how we protect your information, we encourage you to review our Privacy Policy.
BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.
Our Impact
Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.
Unity Confirm™ enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne's Fetal Cell Capture™ Technology.
Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.
Our Growth
From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.
Our Recognition
Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.
Our Future
Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.
Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com